Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sarada Gurubhagavatula"'
Autor:
Thomas J. Lynch, Panos Fidias, John R. Clark, Gilbert H. Daniels, Sarada Gurubhagavatula, Jennifer S. Temel, Lori J. Wirth, Nathan A. Pennell, Tracey L. Evans, Rebecca S. Heist, Douglas S. Ross, Robert I. Haddad
Publikováno v:
Thyroid. 18:317-323
To determine the efficacy of gefitinib in patients with advanced thyroid cancer.In this open-label phase II trial, 27 patients with radioiodine-refractory, locally advanced, or metastatic thyroid cancer were treated with 250 mg of daily gefitinib. Hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8674af1897e1205ee9f1b27f770f9955
https://doi.org/10.1089/thy.2007.0120
https://doi.org/10.1089/thy.2007.0120
Autor:
Wei Zhou, Zhaoxi Wang, Rebecca S. Heist, Kofi Asomaning, Geoffrey Liu, Sarada Gurubhagavatula, David C. Christiani, Li Su, Thomas J. Lynch, Beow Y. Yeap
Publikováno v:
The Pharmacogenomics Journal. 8:129-138
The-216G/T, -191C/A, intron 1 and Arg497Lys epidermal growth factor receptor (EGFR) polymorphisms were evaluated in 92 advanced non-small-cell lung cancer patients treated with gefitinib, an EGFR tyrosine-kinase inhibitor. Improved progression free s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaaaeefbd077b32e5f2389de5f6f6a7
https://doi.org/10.1038/sj.tpj.6500444
https://doi.org/10.1038/sj.tpj.6500444
Publikováno v:
Seminars in Respiratory and Critical Care Medicine. 26:298-303
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in the United States. Patients with early stage NSCLC have a reasonable chance of cure with surgery, but unfortunately, fewer than half of all newly diagnosed NSCLC p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695be4967089e94e294a30141484c696
https://doi.org/10.1055/s-2005-871988
https://doi.org/10.1055/s-2005-871988
Autor:
Patricia L. Harris, Raffaella Sordella, David C. Christiani, Frank G. Haluska, Daniel A. Haber, Sarada Gurubhagavatula, Jeffrey G. Supko, Brian W. Brannigan, Sara M. Haserlat, Daphne W. Bell, Jeff Settleman, Ross A. Okimoto, Thomas J. Lynch, David N. Louis
Publikováno v:
New England Journal of Medicine. 350:2129-2139
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14ffd2cee533df8f5470331bcc46e8f
https://doi.org/10.1056/nejmoa040938
https://doi.org/10.1056/nejmoa040938
Autor:
Teresa Gomez-Isla, Stephen D. Schmidt, John H. Growdon, P. D. Jondro, Rudy Tanzi, Wilma Wasco, Peter Seubert, W P Pettingell, L A Rodes, B. T. Hyman, Sarada Gurubhagavatula, DiBlasi T, Dale Schenk, Whitfield B. Growdon, Megan J. McNamara
Publikováno v:
Annals of Neurology. 41:809-813
The prevalence of known mutations in presenilin genes (PS1 and PS2) causing early-onset familial Alzheimer's disease (FAD) was assessed in a population of 98 singleton early-onset AD cases, 29 early-onset FAD cases, and 15 late-onset FAD cases. None
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a79c32ebc7549bbbfa7ffbdeeae99036
https://doi.org/10.1002/ana.410410618
https://doi.org/10.1002/ana.410410618
Autor:
Rudolph E. Tanzi, Sangram S. Sisodia, Bradley T. Hyman, Wilma Wasco, Sarada Gurubhagavatula, Donna M. Romano, Rachael L. Neve, Marc d. Paradis
Publikováno v:
Nature Genetics. 5:95-100
Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early-onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079efb5704a8059eb8e6191766bb3fa0
https://doi.org/10.1038/ng0993-95
https://doi.org/10.1038/ng0993-95
Autor:
C. Chris Yun, Steven R. Brant, Sarada Gurubhagavatula, Jami Montgomery, Chung Ming Tse, Mark Donowitz, Susan A. Levine, Michael Cohen, Jacques Pouyssegur, Edward J. Cragoe
Publikováno v:
Journal of Biological Chemistry. 268:206-211
Methylprednisolone stimulates rabbit ileal neutral NaCl absorption; and aminoglutethimide, which decreases glucocorticoid levels, decreases NaCl absorption. Studies were carried out to determine the mechanism of these effects and to determine which m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e735d0c25514d2218b84037756e632a5
https://doi.org/10.1016/s0021-9258(18)54135-1
https://doi.org/10.1016/s0021-9258(18)54135-1
Autor:
John C. Wain, David C. Christiani, Sarada Gurubhagavatula, Donna Neuberg, Wei Zhou, Rebecca Suk, Thomas J. Lynch, Geoffrey Liu, Li Su, Sohee Park
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 11(4)
Purpose: ERCC1 is a lead enzyme in the nucleotide excision repair pathway of DNA repair. Polymorphisms have been identified in the ERCC1 gene, the C8092A and codon 118 polymorphisms, which may lead to an altered capacity to regenerate damaged normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a295067abda25458cbedaf43a656ab5a
https://pubmed.ncbi.nlm.nih.gov/15746057
https://pubmed.ncbi.nlm.nih.gov/15746057
Autor:
Geoffrey Liu, John C. Wain, Thomas J. Lynch, David C. Christiani, Sarada Gurubhagavatula, Wei Zhou, Li Su, Sohee Park, Donna Neuberg
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(15)
DNA repair is a critical mechanism of resistance to platinum-based chemotherapy. Excision repair cross-complementation group 1 (ERCC1) is the lead enzyme in the nucleotide excision repair process. Increased ERCC1 mRNA levels are related directly to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cd45a3023b2ec51d6c221880ccee22
https://pubmed.ncbi.nlm.nih.gov/15297394
https://pubmed.ncbi.nlm.nih.gov/15297394
Autor:
John C. Wain, Sarada Gurubhagavatula, Thomas J. Lynch, Sohee Park, Donna Neuberg, Li Su, Geoffrey Liu, David C. Christiani, Wei Zhou
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 22(13)
Purpose Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and may explain interindividual differences in overall survival after therapy with pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bda844399f8047563bfcdaacb9edeac
https://pubmed.ncbi.nlm.nih.gov/15173210
https://pubmed.ncbi.nlm.nih.gov/15173210