Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Saracatinib"'
Autor:
Ruiyang Ma, Huanjing Bi, Ying Wang, Jingwen Wang, Jiangwei Zhang, Xiaoyang Yu, Zuhan Chen, Jiale Wang, Cuinan Lu, Jin Zheng, Yang Li, Xiaoming Ding
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Optimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In this study, we used the small molecule inhibitor saracatinib (SAR) to enhance DE differentiation of hu
Externí odkaz:
https://doaj.org/article/b2d0dbd19811407d92e530016627af80
Autor:
Suraj S. Vasanthi, Nyzil Massey, Suresh N. Nair, Jonathan P. Mochel, Lucas Showman, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Saracatinib/AZD0530 (SAR), a Src tyrosine kinase inhibitor, mitigates seizure-induced brain pathology in epilepsy models upon repeated oral dosing. However, repeated dosing is stressful and can be challenging in some seizing animals. To overcome this
Externí odkaz:
https://doaj.org/article/7c514cee98144e1db9ae0052e453e9fa
Akademický článek
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Autor:
Bernard J. Smilde, Clemens Stockklausner, Richard Keen, Andrew Whittaker, Alex N. Bullock, Annette von Delft, Natasja M. van Schoor, Paul B. Yu, E. Marelise W. Eekhoff
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background Fibrodysplasia Ossificans Progressiva (FOP) is a genetic, progressive and devastating disease characterized by severe heterotopic ossification (HO), loss of mobility and early death. There are no FDA approved medications. The STOP
Externí odkaz:
https://doaj.org/article/fdc788d39fcf447e80cb3cacd3eed9c2
Publikováno v:
BMC Neuroscience, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits often result from hippo
Externí odkaz:
https://doaj.org/article/37c86ef5fc7b44f39d5182cea81a6704
Autor:
Xia Liao, Ge Song, Zihan Xu, Yang Bu, Fan Chang, Fengan Jia, Xuelian Xiao, Xuejiao Ren, Mei Zhang, Qingan Jia
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportunity to impede tumor t
Externí odkaz:
https://doaj.org/article/09a0088263ad4fa4a43290b1694a48b2
Autor:
C. Veith, M. A. Schneider, L. Maas, A. van der Vliet, F. J. van Schooten, M. Kreuter, M. Meister, A. W. Boots, N. Kahn
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 443 (2023)
Idiopathic pulmonary fibrosis (IPF) has a detrimental prognosis despite antifibrotic therapies to which individual responses vary. IPF pathology is associated with oxidative stress, inflammation and increased activation of SRC family kinases (SFK). T
Externí odkaz:
https://doaj.org/article/32f3e91e57d44410b5101620a3396c51
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Meghan Gage, Marson Putra, Crystal Gomez-Estrada, Madison Golden, Logan Wachter, Megan Gard, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Acute organophosphate (OP) toxicity poses a significant threat to both military and civilian personnel as it can lead to a variety of cholinergic symptoms including the development of status epilepticus (SE). Depending on its severity, SE can lead to
Externí odkaz:
https://doaj.org/article/f3f8aabf783b450db21df5b8a538e0c4
Autor:
Summer L. Thompson, Carol A. Gianessi, Stephanie S. O'Malley, Dana A. Cavallo, Julia M. Shi, Jeanette M. Tetrault, Kelly S. DeMartini, Ralitza Gueorguieva, Brian Pittman, John H. Krystal, Jane R. Taylor, Suchitra Krishnan-Sarin
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, are implicated in behavioral and molecular consequences of chronic alcohol use, making the NMDAR a pr
Externí odkaz:
https://doaj.org/article/cfa235b707774310940884984f0fcc28