Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sara-Jane Dunn"'
Autor:
Bertille Montibus, Ramy Ragheb, Evangelia Diamanti, Sara-Jane Dunn, Nicola Reynolds, Brian Hendrich
Publikováno v:
Biology Open, Vol 13, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/f27234afd3514c21be4014d18f86954d
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 47-63 (2023)
Summary: A major challenge in single-cell gene expression analysis is to discern meaningful cellular heterogeneity from technical or biological noise. To address this challenge, we present entropy sorting (ES), a mathematical framework that distingui
Externí odkaz:
https://doaj.org/article/a91d520927f84cbb9228913be102c1a9
Autor:
Ajay Mishra, Bénédicte Oulès, Angela Oliveira Pisco, Tony Ly, Kifayathullah Liakath-Ali, Gernot Walko, Priyalakshmi Viswanathan, Matthieu Tihy, Jagdeesh Nijjher, Sara-Jane Dunn, Angus I Lamond, Fiona M Watt
Publikováno v:
eLife, Vol 6 (2017)
Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here, we characterise commitment by integrating transcriptomic and
Externí odkaz:
https://doaj.org/article/2df07b38696f4e27bfbda3fe780a3c64
Autor:
James M Osborne, Miguel O Bernabeu, Maria Bruna, Ben Calderhead, Jonathan Cooper, Neil Dalchau, Sara-Jane Dunn, Alexander G Fletcher, Robin Freeman, Derek Groen, Bernhard Knapp, Greg J McInerny, Gary R Mirams, Joe Pitt-Francis, Biswa Sengupta, David W Wright, Christian A Yates, David J Gavaghan, Stephen Emmott, Charlotte Deane
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003506 (2014)
Externí odkaz:
https://doaj.org/article/7e501827514d4598aa43b6895de6034c
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80516 (2013)
Cell migration in the intestinal crypt is essential for the regular renewal of the epithelium, and the continued upward movement of cells is a key characteristic of healthy crypt dynamics. However, the driving force behind this migration is unknown.
Externí odkaz:
https://doaj.org/article/0c4cd511f9b0446f848ccf43a2d50885
Autor:
Gary R Mirams, Christopher J Arthurs, Miguel O Bernabeu, Rafel Bordas, Jonathan Cooper, Alberto Corrias, Yohan Davit, Sara-Jane Dunn, Alexander G Fletcher, Daniel G Harvey, Megan E Marsh, James M Osborne, Pras Pathmanathan, Joe Pitt-Francis, James Southern, Nejib Zemzemi, David J Gavaghan
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 3, p e1002970 (2013)
Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac ele
Externí odkaz:
https://doaj.org/article/8531a43edb6e47d7b0e7c4580474c6b9
Autor:
Sara-Jane Dunn, Paul L Appleton, Scott A Nelson, Inke S Näthke, David J Gavaghan, James M Osborne
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 5, p e1002515 (2012)
The role of the basement membrane is vital in maintaining the integrity and structure of an epithelial layer, acting as both a mechanical support and forming the physical interface between epithelial cells and the surrounding connective tissue. The f
Externí odkaz:
https://doaj.org/article/14aa66f6cfb948e096a6538c514f2793
Autor:
Nan Rosemary Ke, Sara-Jane Dunn, Jorg Bornschein, Silvia Chiappa, Melanie Rey, Jean-Baptiste Lespiau, Albin Cassirer, Jane Wang, Theophane Weber, David Barrett, Matthew Botvinick, Anirudh Goyal, Mike Mozer, Danilo Rezende
Accurately inferring Gene Regulatory Networks (GRNs) is a critical and challenging task in biology. GRNs model the activatory and inhibitory interactions between genes and are inherently causal in nature. To accurately identify GRNs, perturbational d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94f868c7b7b9fbcaad5d4d504103b88
http://arxiv.org/abs/2304.05823
http://arxiv.org/abs/2304.05823
Autor:
Bertille Montibus, Ramy Ragheb, Evangelia Diamanti, Sara-Jane Dunn, Nicola Reynolds, Brian Hendrich
As cells exit the pluripotent state and begin to commit to a specific lineage they must activate genes appropriate for that lineage while silencing genes associated with pluripotency and preventing activation of lineage-inappropriate genes. The Nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3863b09fd09b8709b6c250182beee0
https://doi.org/10.1101/2023.02.09.527610
https://doi.org/10.1101/2023.02.09.527610
A major challenge in single cell gene expression analysis is to discern meaningful cellular heterogeneity from technical or biological noise. To address this challenge, we present Entropy Sorting, a mathematical framework that distinguishes genes ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1998acbb040895214a513cd8ae2c497
https://www.repository.cam.ac.uk/handle/1810/341386.2
https://www.repository.cam.ac.uk/handle/1810/341386.2