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Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase
Publikováno v:
Biochemical and biophysical research communications. 497(2)
HIV-1 reverse transcriptase (RT) in the cytoplasm of HIV-infected cells efficiently inserts the non-canonical dUTP into the proviral DNA, and extends the dU-terminated DNA. The misincorporation of dUTP leads to mutagenesis, and uracils can down-regul