2508

Autor: Sara Blick, Craig Morrell, Sara Ture, David J. Field

Publikováno v: Journal of Clinical and Translational Science, Vol 1, Pp 10-10 (2017)

OBJECTIVES/SPECIFIC AIMS: To investigate the role of platelet factor-4 (PF4) in B cell differentiation and develop strategies to better modulate B cell differentiation in vitro and in vivo. METHODS/STUDY POPULATION: We use tissue culture and flow cyt

Externí odkaz: https://doaj.org/article/b5ea29a9142d4260aded03a26d25c74c

Platelet-derived β2m regulates age related monocyte/macrophage functions

Autor: Allison Arne, Sara Ture, Craig N. Morrell, Zachary T. Hilt, Amy Mohan

Publikováno v: Aging (Albany NY)

Platelets have central roles in both immune responses and development. Stimulated platelets express leukocyte adhesion molecules and release numerous immune modulatory factors that recruit and activate leukocytes, both at the sites of activation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f85b50752a7a1814ee256bea4b670f
https://doi.org/10.18632/aging.102520

Acetylcholine Inhibits Platelet Activation

Autor: David I. Yule, Rachel Schmidt, Sara Ture, Scott J. Cameron, Charles J. Lowenstein, Michael A. Mastrangelo, John A. Bennett, Craig N. Morrell, Lara E. Terry

Publikováno v: J Pharmacol Exp Ther

Platelets are key mediators of thrombosis. Many agonists of platelet activation are known, but fewer endogenous inhibitors of platelets, such as prostacyclin and nitric oxide (NO), have been identified. Acetylcholinesterase inhibitors, such as donepe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f98483ea49f6463a8c9d1ce68f636f
https://doi.org/10.1124/jpet.118.253583

Lung megakaryocytes are immune modulatory cells

Autor: Steve N. Georas, Kathleen E. McGrath, Laura Tesoro Santos, Ferralita Madere, Janelle Veazey, Mark R. Looney, Jerry Saunders, Claire E. Lyons, Allison Arne, Estheany Roman-Pagan, James Palis, Kelly A. Metcalf-Pate, Alison C. Livada, Nguyen P.T. Huynh, Daphne N. Pariser, Sara Ture, Simon J. Cleary, Craig N. Morrell, Sara K. Blick-Nitko, Zachary T. Hilt, Selena M. Guerrero-Martin

Publikováno v: Pariser, D N, Hilt, Z T, Ture, S K, Blick-Nitko, S K, Looney, M R, Cleary, S J, Roman-Pagan, E, Saunders, J, Georas, S N, Veazey, J, Madere, F, Santos, L T, Arne, A, Huynh, N P T, Livada, A C, Guerrero-Martin, S M, Lyons, C, Metcalf-Pate, K A, McGrath, K E, Palis, J & Morrell, C N 2021, ' Lung megakaryocytes are immune modulatory cells ', Journal of Clinical Investigation, vol. 131, no. 1, e137377 . https://doi.org/10.1172/JCI137377
J Clin Invest

Although platelets are the cellular mediators of thrombosis, they are also immune cells. Platelets interact both directly and indirectly with immune cells, impacting their activation and differentiation, as well as all phases of the immune response.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd1a5be2cf864f0b896f8b832d8c080
https://curis.ku.dk/portal/da/publications/lung-megakaryocytes-are-immune-modulatory-cells(033da7c0-64a2-40ec-905b-eedb57a93943).html

Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection

Autor: Meera V. Singh, Sara Ture, Joseph W. Jackson, Craig N. Morrell, Sumanun Suwunnakorn, Vir B. Singh, Emily A. Weber, Sanjay B. Maggirwar

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Microvesicles are cell membrane–derived vesicles that have been shown to augment inflammation. Specifically, monocyte‐derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc9521d7140e5a3642af7455d6d020b
http://europepmc.org/articles/PMC7660781