Výsledky vyhledávání - "Sara Triulzi"

The Interleukin-8 (IL-8/CXCL8) Receptor Inhibitor Reparixin Improves Neurological Deficits and Reduces Long-term Inflammation in Permanent and Transient Cerebral Ischemia in Rats

Autor: Sara Triulzi, Riccardo Bertini, Luigi Sironi, Rosa Di Bitondo, Pietro Ghezzi, Tiziana Mennini, Sara Barbera, Paolo Bigini, B Cavalieri, Pia Villa, Elena Tremoli, Paolo Gelosa

Publikováno v: Molecular Medicine. 13:125-133

Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We previously reported that reparixin, a CXCL8 receptor blocker that inhibits neutrophil infiltration, and related molecules can reduce infarct size in a rat model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb7626ad228b9330282b69ebdf6cbe0
https://doi.org/10.2119/2007-00008.villa

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Development of a systemically-active dual CXCR1/CXCR2 allosteric inhibitor and its efficacy in a model of transient cerebral ischemia in the rat

Autor: Angela, Garau, Riccardo, Bertini, Marco, Mosca, Cinzia, Bizzarri, Roberto, Anacardio, Sara, Triulzi, Marcello, Allegretti, Pietro, Ghezzi, Pia, Villa

Publikováno v: European cytokine network. 17(1)

The chemokine receptors CXCR1 and CXCR2 present on polymorphonuclear neutrophils (PMN), bind the chemokine CXC ligand 8 (CXCL8)/interleukin-8 (IL-8), and have a key role in PMN recruitment in inflammation. Based on the structure of reparixin, a small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec2ffcdb8519f88f6a5638b808be640a
https://pubmed.ncbi.nlm.nih.gov/16613761

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