Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sara Tommasi"'
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract There is increasing interest in the pathophysiological role of arginine metabolism in schizophrenia, particularly in relation to the modulation of the endogenous messenger nitric oxide (NO). The assessment of specific arginine metabolites th
Externí odkaz:
https://doaj.org/article/051fdc4f4fbc4b2a99374a56923d6a16
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27292- (2024)
Alterations of nitric oxide (NO) homeostasis have been described in mood disorders. However, the analytical challenges associated with the direct measurement of NO have prompted the search for alternative biomarkers of NO synthesis. We investigated t
Externí odkaz:
https://doaj.org/article/0997747290784ab69f0e44f3ced1bb91
Autor:
Vinitha N. Ragavan, Pramod C. Nair, Natalia Jarzebska, Ramcharan Singh Angom, Luana Ruta, Elisa Bianconi, Silvia Grottelli, Natalia D. Tararova, Daniel Ryazanskiy, Steven R. Lentz, Sara Tommasi, Jens Martens-Lobenhoffer, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Elena Rubets, Sarah Chau, Yingjie Chen, Xinli Hu, Nadine Bernhardt, Peter M. Spieth, Norbert Weiss, Stefan R. Bornstein, Debabrata Mukhopadhyay, Stefanie M. Bode-Böger, Renke Maas, Ying Wang, Antonio Macchiarulo, Arduino A. Mangoni, Barbara Cellini, Roman N. Rodionov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cardiovascular disease by metabolising the risk factor asymmetric dimethylarginine (ADMA). However, the question whether the second DDAH isoform, DDAH2, directly metabolises
Externí odkaz:
https://doaj.org/article/c46891e5d10241cf95a530af2ca4d6b5
Autor:
Arduino A. Mangoni, Salvatore Sotgia, Angelo Zinellu, Ciriaco Carru, Gianfranco Pintus, Giovanni Damiani, Gian Luca Erre, Sara Tommasi
Publikováno v:
Therapeutic Advances in Cardiovascular Disease, Vol 17 (2023)
New evidence continues to accumulate regarding a significant association between excessive inflammation and dysregulated immunity (local and systemic) and the risk of cardiovascular events in different patient cohorts. Whilst research has sought to i
Externí odkaz:
https://doaj.org/article/ed8d7d4d30d747628dd8e4a82f9fe992
Autor:
Tien F. Lee, Sara Tommasi, Andrew Bersten, Leonie K. Heilbronn, Salvatore Sotgia, Angelo Zinellu, Ciriaco Carru, Arduino A. Mangoni, Morton G. Burt
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-7 (2023)
Abstract Background Changes in the arginine metabolites asymmetric dimethyl-L-arginine (ADMA) and L-homoarginine and acute blood glucose concentrations have been shown to cause endothelial dysfunction and be independently associated with mortality in
Externí odkaz:
https://doaj.org/article/e968b737d3c846d499deef3a9f6eca08
Autor:
Tommaso Ceruti, Roberta Frapolli, Carmen Ghilardi, Alessandra Decio, Giulia Dellavedova, Sara Tommasi, Massimo Zucchetti, Arduino A. Mangoni
Publikováno v:
Molecules, Vol 28, Iss 24, p 8056 (2023)
We describe the development and validation of an HPLC-MS/MS method to assess the pharmacokinetics and tumour distribution of ZST316, an arginine analogue with inhibitory activity towards dimethylarginine dimethylaminohydrolase 1 (DDAH1) and vasculoge
Externí odkaz:
https://doaj.org/article/85bae41d3b3a456cbde0323d0c2398bf
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 602-612 (2019)
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a key enzyme involved in the metabolism of the endogenous nitric oxide synthase (NOS) inhibitors asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA). Increased DDAH1 expression and
Externí odkaz:
https://doaj.org/article/f12e7a27f8c24085bb0c496ff306eed0
Autor:
Julie-Ann Hulin, Ekaterina A. Gubareva, Natalia Jarzebska, Roman N. Rodionov, Arduino A. Mangoni, Sara Tommasi
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
The small free radical gas nitric oxide (NO) plays a key role in various physiological and pathological processes through enhancement of endothelial cell survival and proliferation. In particular, NO has emerged as a molecule of interest in carcinoge
Externí odkaz:
https://doaj.org/article/c10e998d2119443ca13084cf098604fa
Autor:
Arduino A. Mangoni, Tommaso Ceruti, Roberta Frapolli, Massimo Russo, Stefania Fichera, Massimo Zucchetti, Sara Tommasi
Publikováno v:
Molecules, Vol 27, Iss 3, p 1017 (2022)
The pharmacokinetic profile of ZST316 and ZST152, arginine analogues with inhibitory activity towards human dimethylarginine dimethylaminohydrolase-1 (DDAH1), was investigated in mice using a newly developed HPLC-MS/MS method. The method proved to be
Externí odkaz:
https://doaj.org/article/4a45c0c788334f97a913322762314779
Autor:
Arduino A Mangoni, Sara Tommasi, Angelo Zinellu, Salvatore Sotgia, Ciriaco Carru, Matteo Piga, Gian Luca Erre
Publikováno v:
Drugs in Context, Vol 7, Pp 1-12 (2018)
About 20% of patients with a history of atherosclerotic cardiovascular disease will experience further cardiovascular events despite maximal pharmacological treatment with cardioprotective drugs. This highlights the presence of residual cardiovascula
Externí odkaz:
https://doaj.org/article/6827e5eca7b74047b4500550fc4d9222