Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses

Autor: Susanne Krasemann, Carsten Dittmayer, Saskia von Stillfried, Jenny Meinhardt, Fabian Heinrich, Kristin Hartmann, Susanne Pfefferle, Edda Thies, Regina von Manitius, Tom Alex David Aschman, Josefine Radke, Anja Osterloh, Simone Schmid, Eva Miriam Buhl, Jana Ihlow, Frank Dubois, Viktor Arnhold, Sefer Elezkurtaj, David Horst, Andreas Hocke, Sara Timm, Sebastian Bachmann, Victor Corman, Hans-Hilmar Goebel, Jakob Matschke, Stephanie Stanelle-Bertram, Gülsah Gabriel, Danielle Seilhean, Homa Adle-Biassette, Benjamin Ondruschka, Matthias Ochs, Werner Stenzel, Frank L. Heppner, Peter Boor, Helena Radbruch, Michael Laue, Markus Glatzel

Publikováno v: EBioMedicine, Vol 83, Iss , Pp 104193- (2022)

Summary: Background: Autopsy studies have provided valuable insights into the pathophysiology of COVID-19. Controversies remain about whether the clinical presentation is due to direct organ damage by SARS-CoV-2 or secondary effects, such as overshoo

Externí odkaz: https://doaj.org/article/8c3f588c9dc544439b18fd7f7d5e9f6b

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

Autor: Felix Meyer, Saskia Becker, Sandra Classen, Ann Christin Parplys, Wael Yassin Mansour, Britta Riepen, Sara Timm, Claudia Ruebe, Maria Jasin, Harriet Wikman, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann

Publikováno v: Cells, Vol 9, Iss 1, p 238 (2020)

Chromosomal instability not only has a negative effect on survival in triple-negative breast cancer, but also on the well treatable subgroup of luminal A tumors. This suggests a general mechanism independent of subtypes. Increased chromosomal instabi

Externí odkaz: https://doaj.org/article/b53ca6d143a1471da7002a4f957552d2

Monitoring tubular epithelial cell damage in AKI via urine flow cytometry

Autor: Jacob Kujat, Valerie Langhans, Hannah Brand, Paul Freund, Nina Görlich, Leonie Wagner, Diana Metzke, Sara Timm, Matthias Ochs, Andreas Grützkau, Sabine Baumgart, Christopher M. Skopnik, Falk Hiepe, Gabriela Riemekasten, Jan Klocke, Philipp Enghard

IntroductionAcute kidney injury (AKI) is associated with significant morbidity and mortality. The diagnosis is currently based on urine output and serum creatinine and there is a lack of biomarkers that directly reflect tubular damage. Here, we estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::728035f115bf5308b80652b888965355
https://doi.org/10.1101/2022.01.31.22270101

Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient

Autor: Jenny Meinhardt, Sara Timm, Martin Witzenrath, Matthias Ochs, Steffen Weber-Carstens, Frank L. Heppner, David Horst, Sefer Elezkurtaj, Andreas C. Hocke

Publikováno v: The European respiratory journal 57(5), 2004165-(2021). doi:10.1183/13993003.04165-2020
The European Respiratory Journal
article-version (AM) Accepted Manuscript

The delicate alveolar blood-air barrier is a primary target in Coronavirus disease 2019 (COVID-19). Its micro-architecture consists of an alveolar epithelium composed of type I and type II cells and covered with surfactant, a thin interstitium and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0021db248f15a84338c7d843c0cd009e
https://pub.dzne.de/record/157787

Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation

Autor: Sara Timm, Yvonne Lorat, Burkhard Jakob, Gisela Taucher-Scholz, Claudia E. Rübe

Publikováno v: Radiotherapy and Oncology. 121:154-161

Background and purpose High linear energy transfer (LET) radiotherapy offers superior dose conformity and biological effectiveness compared with low-LET radiotherapy, representing a promising alternative for radioresistant tumours. A prevailing hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3082d5604e48ac07d5449262b6cf92
https://doi.org/10.1016/j.radonc.2016.08.028