Inflammatory Dendritic Cells Contribute to Regulate the Immune Response in Sickle Cell Disease

Autor: Renata Sesti-Costa, Marina Dorigatti Borges, Carolina Lanaro, Dulcinéia Martins de Albuquerque, Sara Terezinha Olalla Saad, Fernando Ferreira Costa

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Sickle cell disease (SCD), one of the most common hemoglobinopathies worldwide, is characterized by a chronic inflammatory component, with systemic release of inflammatory cytokines, due to hemolysis and vaso-occlusive processes. Patients with SCD de

Externí odkaz: https://doaj.org/article/09a63da267c24f1e98272b46ae8e1753

Clinical, hematological, and molecular characterization of sickle cell anemia pediatric patients from two different cities in Brazil Caracterização clínica, hematológica e molecular de crianças portadoras da anemia falciforme em duas diferentes cidades do Brasil

Autor: Isa Menezes Lyra, Marilda Souza Gonçalves, Joseffina A. Pellegrinei Braga, Maria de Fátima Gesteira, Maria Helena Carvalho, Sara Terezinha Olalla Saad, Maria Stella Figueiredo, Fernando Ferreira Costa

Publikováno v: Cadernos de Saúde Pública, Vol 21, Iss 4, Pp 1287-1290 (2005)

This study focused on clinical, hematological, and molecular aspects of sickle cell anemia pediatric patients from two different cites in Brazil. Seventy-one patients from São Paulo and Salvador, aged 3 to 18 years, were evaluated. Hematological ana

Externí odkaz: https://doaj.org/article/26e7a8c110b44841a5f287b39d80c8b7

Low SARS-CoV-2 seroprevalence in a cohort of Brazilian sickle cell disease patients: Possible effects of emphasis on social isolation for a population initially considered to be at very high risk

Autor: Paula de Melo Campos, Marcelo Addas-Carvalho, Bruno Deltreggia Benites, Luiza Francisco Trafane, Vitor A. Costa, Samuel de Souza Medina, Adriana S. S. Duarte, Audrey Basso Zangirolami, Sara Terezinha Olalla Saad, José Luiz Proença-Módena

Publikováno v: Ejhaem

Despite being initially considered at higher risk for severe COVID‐19, sickle cell disease (SCD) patients have mostly presented clinical severity similar to the general population. As their vulnerability to become infected remains uncertain, we ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b265f26338f5f597a77c1ae09292253f
https://pubmed.ncbi.nlm.nih.gov/34518833

SIVA, a target of p53, is downregulated in myelodysplastic syndromes

Autor: Fernando Ferreira Costa, João Agostinho Machado-Neto, Patricia Favaro, Renata Scopim-Ribeiro, Mariana Lazarini, Paula de Melo Campos, Irene Lorand-Metze, Sara Terezinha Olalla Saad, Fabiola Traina

Publikováno v: Applied Cancer Research, Vol 37, Iss 1, Pp 1-7 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its association with clinical features and TP53 and MDM2 expression in bone m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf1124ef9c36c14a3c1f94096003038
http://link.springer.com/article/10.1186/s41241-017-0033-9

Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15

Autor: Kleber Yotsumoto Fertrin, Betania Lucena Domingues Hatzlhofer, Aderson S Araujo, Dulcineia M. Albuquerque, Sara Terezinha Olalla Saad, Marcos André Cavalcanti Bezerra, Carolina Lanaro, Carla F. Franco-Penteado, Flavia Rubia Pallis, Mark Westerman, Mariana R. B. Mello, Fernando Ferreira Costa, Gordana Olbina

Publikováno v: American Journal of Hematology. 89:385-390

Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased concentrations found in patients with ineffective erythropoiesis (IE)suggest that hepcidin deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8beb3f1fadca2123668b16a77d4e2bf
https://doi.org/10.1002/ajh.23649