Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sara Ten Have"'
Autor:
Jun Zhan, Frank Harwood, Sara Ten Have, Angus Lamond, Aaron H. Phillips, Richard W. Kriwacki, Priyanka Halder, Monica Cardone, Gerard C. Grosveld
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10042 (2024)
mTOR plays a crucial role in cell growth by controlling ribosome biogenesis, metabolism, autophagy, mRNA translation, and cytoskeleton organization. It is a serine/threonine kinase that is part of two distinct extensively described protein complexes,
Externí odkaz:
https://doaj.org/article/bd0857ad081b45ab8b156bf4a39987f5
Autor:
Vanesa Alvarez, Susanne Bandau, Hao Jiang, Diana Rios-Szwed, Jens Hukelmann, Elisa Garcia-Wilson, Nicola Wiechens, Eva Griesser, Sara Ten Have, Tom Owen-Hughes, Angus Lamond, Constance Alabert
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111996- (2023)
Summary: Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA-bound proteins, and it is unclear how they regain acces
Externí odkaz:
https://doaj.org/article/1a042ff554f14fca972efa6c2e4f302b
Publikováno v:
Fly, Vol 14, Iss 1-4, Pp 10-28 (2020)
Quantitative proteomic analyses in combination with genetics provide powerful tools in developmental cell signalling research. Drosophila melanogaster is one of the most widely used genetic models for studying development and disease. Here we combine
Externí odkaz:
https://doaj.org/article/ed9f1781c79142c6bac0bb4f1cc889d9
Autor:
A. Gregory Matera, Amanda C. Raimer, Casey A. Schmidt, Jo A. Kelly, Gaith N. Droby, David Baillat, Sara ten Have, Angus I. Lamond, Eric J. Wagner, Kelsey M. Gray
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 491-503 (2019)
Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival motor neuron 1 (SMN1) gene. SMN protein has a well-characterized role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), core components of the spliceo
Externí odkaz:
https://doaj.org/article/c52889db62ab45b8b93dc506e82567c4
Autor:
Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency l
Externí odkaz:
https://doaj.org/article/14616f7f675c4e30b80ba40a1401b765
Autor:
Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency l
Externí odkaz:
https://doaj.org/article/11969b6df6324a9fab1ed4098282a9b4
Autor:
Katharina Schleicher, Michael Porter, Sara ten Have, Ramasubramanian Sundaramoorthy, Iain M. Porter, Jason R. Swedlow
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Regulation of protein phosphatase activity by endogenous protein inhibitors is an important mechanism to control protein phosphorylation in cells. We recently identified Biorientation defective 1 (Bod1) as a small protein inhibitor of protein phospha
Externí odkaz:
https://doaj.org/article/afbcbb801cf14923a997a6fbdf777098
Autor:
Farzin Pourfarzad, Ali Aghajanirefah, Ernie de Boer, Sara Ten Have, Thamar Bryn van Dijk, Sima Kheradmandkia, Ralph Stadhouders, Supat Thongjuea, Eric Soler, Nynke Gillemans, Marieke von Lindern, Jeroen Demmers, Sjaak Philipsen, Frank Grosveld
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 589-600 (2013)
Here, we show that transcription factors bound to regulatory sequences can be identified by purifying these unique sequences directly from mammalian cells in vivo. Using targeted chromatin purification (TChP), a double-pull-down strategy with a tetra
Externí odkaz:
https://doaj.org/article/8d951a963b1d4a22a3d36a6b419105f2
Autor:
Wael Abdel-Fattah, Daniel Jablonowski, Rachael Di Santo, Kathrin L Thüring, Viktor Scheidt, Alexander Hammermeister, Sara Ten Have, Mark Helm, Raffael Schaffrath, Michael J R Stark
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004931 (2015)
Elongator is a conserved protein complex comprising six different polypeptides that has been ascribed a wide range of functions, but which is now known to be required for modification of uridine residues in the wobble position of a subset of tRNAs in
Externí odkaz:
https://doaj.org/article/855b1e29320f4b6fa0c56c51d4d5349f
Autor:
Shanow Uthman, Christian Bär, Viktor Scheidt, Shihui Liu, Sara ten Have, Flaviano Giorgini, Michael J R Stark, Raffael Schaffrath
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003334 (2013)
Diphthamide is a highly modified histidine residue in eukaryal translation elongation factor 2 (eEF2) that is the target for irreversible ADP ribosylation by diphtheria toxin (DT). In Saccharomyces cerevisiae, the initial steps of diphthamide biosynt
Externí odkaz:
https://doaj.org/article/7e811bffcb974ade90570e8ba6d1d671