Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sara Teixeira de Macedo Silva"'
Autor:
Gonzalo Visbal, Rodrigo M. S. Justo, Gabrielle dos Santos da Silva e Miranda, Sara Teixeira de Macedo Silva, Wanderley de Souza, Juliany Cola Fernandes Rodrigues, Maribel Navarro
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1113 (2023)
Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis of the new ZnCl2(H3)2 complex. H3 is 22-hydrazone-imidazoline-2-yl-chol-5-ene-3β-ol, a we
Externí odkaz:
https://doaj.org/article/12392f85f2d14f0daac07a0af53a1018
Autor:
Sara Teixeira de Macedo-Silva, Gonzalo Visbal, Gabrielle Frizzo Souza, Mayara Roncaglia dos Santos, Simon B. Cämmerer, Wanderley de Souza, Juliany Cola Fernandes Rodrigues
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to inhibit the squalene synthase (SQS) that catalyzes the first committed reaction on the
Externí odkaz:
https://doaj.org/article/fcc844fae7d349fba865ec456c5321d7
Autor:
Sara Teixeira de Macedo-Silva, Gonzalo Visbal, Gabrielle Frizzo Souza, Mayara Roncaglia dos Santos, Simon B. Cämmerer, Wanderley de Souza, Juliany Cola Fernandes Rodrigues
Publikováno v:
Scientific reports. 12(1)
Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to inhibit the squalene synthase (SQS) that catalyzes the first committed reaction on the sterol bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b91d231bd6c577b32eb60ead70e5cd8
https://pubmed.ncbi.nlm.nih.gov/35788652
https://pubmed.ncbi.nlm.nih.gov/35788652
Autor:
Sara Teixeira de Macedo-Silva, Julio A Urbina, Wanderley de Souza, Juliany Cola Fernandes Rodrigues
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83247 (2013)
Leishmaniasis, caused by protozoan parasites of the Leishmania genus, is one of the most prevalent neglected tropical diseases. It is endemic in 98 countries, causing considerable morbidity and mortality. Pentavalent antimonials are the first line of
Externí odkaz:
https://doaj.org/article/9cac05b2a1444101848844521b36839c
Autor:
Sourav Chatterjee, Vivek Kumar Gupta, Anushree Achari, Wanderley de Souza, Amanda Cristina de Sousa Leite, Aline Araujo Zuma, Jayaraman Vinayagam, Pinaki Bhattacharjee, Parasuraman Jaisankar, Sara Teixeira de Macedo-Silva, Lucas Souza de Castro
Publikováno v:
Experimental parasitology. 224
Chagas disease and leishmaniasis are neglected diseases caused by parasites of the Trypanosomatidae family and together they affect millions of people in the five continents. The treatment of Chagas disease is based on benznidazole, whereas for leish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baebd225de93285580525ab337094b9
https://pubmed.ncbi.nlm.nih.gov/33744229
https://pubmed.ncbi.nlm.nih.gov/33744229
Autor:
Sara Teixeira de Macedo Silva, Jose Aleixo de Azevedo-França, Emile Barrias, Maribel Navarro, Sandra Mara Naressi Scapin, Renato Granado, Luana Pereira Borba-Santos, Juliany Cola Fernandes Rodrigues, Erica S. Martins-Duarte, Gabrielle Dos Santos-Silva, Wanderley de Souza, Sonia Rozental
Publikováno v:
Antimicrobial Agents and Chemotherapy. 64
The new complexes Zn(ITZ) 2 Cl 2 (1) and Zn(ITZ) 2 (OH) 2 (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73e2d943b91d0b9b495ad1b1db6e5466
https://doi.org/10.1128/aac.01980-19
https://doi.org/10.1128/aac.01980-19
Autor:
Wanderley de Souza, Joseane Lima Prado Godinho, Juliany Cola Fernandes Rodrigues, Sara Teixeira de Macedo Silva, Gonzalo Visbal, Julio A. Urbina
Publikováno v:
Journal of Antimicrobial Chemotherapy. 73:2360-2373
Objectives Leishmaniasis, one of the most significant neglected diseases around the world, is caused by protozoan parasites of the Leishmania genus. Nowadays, the available aetiological treatments for leishmaniasis have variable effectiveness and sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91c9e5a659c34f589f91c3206d0d951
https://doi.org/10.1093/jac/dky229
https://doi.org/10.1093/jac/dky229
Autor:
Hemanta K. Majumder, Aline Araujo Zuma, Sara Teixeira de Macedo Silva, Neha Kumari, Sibabrata Mukhopadhyay, Ashok Kumar, Jean-Claude Dujardin, Juliany Cola Fernandes Rodrigues, Joseane Lima Prado Godinho, Syamal Roy, Somenath Roy Chowdhury, Shyam Sundar, Wanderley de Souza, Sourav Saha
Publikováno v:
Biochemical pharmacology
Indole alkaloids possess a large spectrum of biological activities including anti-protozoal action. Here we report for the first time that voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b59bdef5c9bca75290344499f97e3f
https://doi.org/10.1016/j.bcp.2017.05.002
https://doi.org/10.1016/j.bcp.2017.05.002
Autor:
Jose Aleixo de, Azevedo-França, Renato, Granado, Sara Teixeira, de Macedo Silva, Gabrielle Dos, Santos-Silva, Sandra, Scapin, Luana P, Borba-Santos, Sonia, Rozental, Wanderley, de Souza, Érica S, Martins-Duarte, Emile, Barrias, Juliany Cola Fernandes, Rodrigues, Maribel, Navarro
Publikováno v:
Antimicrob Agents Chemother
The new complexes Zn(ITZ)(2)Cl(2) (1) and Zn(ITZ)(2)(OH)(2) (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba61e195b0a9353c290b967260d2b747
https://pubmed.ncbi.nlm.nih.gov/32152072
https://pubmed.ncbi.nlm.nih.gov/32152072
Autor:
Joseane Lima Prado Godinho, Parasuraman Jaisankar, Jayaraman Vinayagam, Sara Teixeira de Macedo Silva, Hemanta K. Majumder, Aline Araujo Zuma, Juliany Cola Fernandes Rodrigues, Somenath Roy Chowdhury, Wanderley de Souza
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Kinetoplast DNA (kDNA) bearing unusual mitochondrion of trypanosomatid parasites offers a new paradigm in chemotherapy modality. Topoisomerase II of Leishmania donovani (LdTopII), a key enzyme associated with kDNA replication, is emerging as a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633b73781ac61dd3a0dd874841846979
http://europepmc.org/articles/PMC6085290
http://europepmc.org/articles/PMC6085290