Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sara Taffi"'
Autor:
Stefano Costanzi, Karl-Norbert Klotz, Rosaria Volpini, Gloria Cristalli, Catia Lambertucci, Sara Taffi, Sauro Vittori
Publikováno v:
Journal of Medicinal Chemistry. 45:3271-3279
A series of N(6)-alkyl-2-alkynyl derivatives of adenosine (Ado) have been synthesized and evaluated for their affinity at human A(1), A(2A), and A(3) receptors and for their potency at A(2B) adenosine receptor subtypes. The corresponding 2-(1-alkynyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a709f05d4c960ea07db6ba17985629c7
https://doi.org/10.1021/jm0109762
https://doi.org/10.1021/jm0109762
Autor:
Sara Taffi, Karl-Norbert Klotz, Sauro Vittori, Rosaria Volpini, Diego Dal Ben, Gloria Cristalli, Catia Lambertucci
A new series of N6-methoxy-2-(ar)alkynyladenosine derivatives has been synthesized and tested at the human recombinant adenosine receptors. Binding studies demonstrated that the new compounds possess high affinity and selectivity for the A3 subtype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789757148bec14ed84d929f2648c97ef
http://hdl.handle.net/11581/9026
http://hdl.handle.net/11581/9026
Autor:
Sara Taffi, Sauro Vittori, Catia Lambertucci, Karl-Norbert Klotz, R. Volpini, Gloria Cristalli
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 24(5-7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1491078e674c44638c230b988f223f08
https://pubmed.ncbi.nlm.nih.gov/16248066
https://pubmed.ncbi.nlm.nih.gov/16248066
Autor:
Catia Lambertucci, Sara Taffi, Sauro Vittori, Rosaria Volpini, Diego Dal Ben, Gloria Cristalli, Floriana R. Portino
Publikováno v:
Collection Symposium Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a415550581d488b84c270445d6e9e73e
https://doi.org/10.1135/css200507087
https://doi.org/10.1135/css200507087
Autor:
Sauro Vittori, Stefano Costanzi, Silvia Vincenzetti, Rosaria Volpini, Gloria Cristalli, Catia Lambertucci, Sara Taffi, Alberto Vita
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 22(5-8)
In the absence of an experimentally elucidated three-dimensional structure of the human CDA, we built an homology model of this enzyme starting from the crystal structure of its E. coli homologous. Furthermore, we docked in the active site alternativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e309ccea18b8b2d01056df6a209ace
https://pubmed.ncbi.nlm.nih.gov/14565461
https://pubmed.ncbi.nlm.nih.gov/14565461
Autor:
Sauro Vittori, Rosaria Volpini, Catia Lambertucci, Alberto Vita, Gloria Cristalli, Daniela Salvatori, Sara Taffi, Silvia Vincenzetti, Stefano Costanzi
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 22(5-8)
N6-Cycloalkyl-2',3'-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4f0a56ec637fc0db5b642abf1188d2
https://pubmed.ncbi.nlm.nih.gov/14565301
https://pubmed.ncbi.nlm.nih.gov/14565301
Purine and Deazapurine Nucleosides: Synthetic Approaches, Molecular Modeling and Biological Activity
Autor:
Sauro Vittori, Catia Lambertucci, Stefano Costanzi, Sara Taffi, Gloria Cristalli, Rosaria Volpini
Publikováno v:
ChemInform. 34
A number of ligands for the adenosine binding sites has been obtained by using nucleoside convergent and divergent synthesis. Most of our nucleosides have been synthesized by coupling 2,6-dichloropurine (1), 2,6-dichloro-1-deazapurine (2), 2,6-dichlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06ccbdabe6b9cd8bdecf067a71b342f
https://doi.org/10.1002/chin.200328246
https://doi.org/10.1002/chin.200328246
Publikováno v:
Current topics in medicinal chemistry. 3(4)
The search for potent and selective A(2A) adenosine receptor agonists has been particularly fruitful in the early nineties. A series of 2-amino, 2-alkoxy, 2-alkythio-, 2-alkynyl-, and 2-alkenyl-derivatives of adenosine (Ado, 1) and N-ethylcarboxamido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0e67d8389b0f04815ba433f6a992c5
https://pubmed.ncbi.nlm.nih.gov/12570757
https://pubmed.ncbi.nlm.nih.gov/12570757
Autor:
Rosaria Volpini, Diego Dal Ben, Catia Lambertucci, Sara Taffi, Sauro Vittori, Karl-Norbert Klotz, Gloria Cristalli
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 6, p1222-1230, 9p