Výsledky vyhledávání - "Sara Sjöberg"

Akademický článek

A guanidine‐rich regulatory oligodeoxynucleotide improves type‐2 diabetes in obese mice by blocking T‐cell differentiation

Autor: Xiang Cheng, Jing Wang, Ni Xia, Xin‐Xin Yan, Ting‐Ting Tang, Han Chen, Hong‐Jian Zhang, Juan Liu, Wen Kong, Sara Sjöberg, Eduardo Folco, Peter Libby, Yu‐Hua Liao, Guo‐Ping Shi

Publikováno v: EMBO Molecular Medicine, Vol 4, Iss 10, Pp 1112-1125 (2012)

Abstract T lymphocytes exhibit pro‐inflammatory or anti‐inflammatory activities in obesity and diabetes, depending on their subtypes. Guanidine‐rich immunosuppressive oligodeoxynucleotides (ODNs) effectively control Th1/Th2‐cell counterbalanc

Externí odkaz: https://doaj.org/article/15dbd637520a469986f881e3c926087a

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Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

Autor: Yi Zhou, Lijun Zhang, Karine Clément, Farid Bensaid, Guo-Ping Shi, Joséphine Roux, Gökhan S. Hotamisligil, Xueqing Yu, Chih-Hao Lee, Jian Liu, Huimei Chen, Peter Libby, Sara Sjöberg, Al-Habib Ivoulsou, Joan Tordjman, Cong-Lin Liu

Publikováno v: Cell Metabolism. 22:1045-1058

SummaryMast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory functions. MCs in the white adipose tissue (WAT) of lean humans and mice express neglig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2d022e4eec7f3dc9b34ce2db0b1cdf
https://doi.org/10.1016/j.cmet.2015.09.013

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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Autor: Peter Libby, Petri T. Kovanen, Adam Lesner, Katariina Öörni, Jing Wang, Blandine Secco, Tingting Tang, Sara Sjöberg, Cleverson Rodrigues Fernandes, Wenxue Wu, Viviane Tia, Cong-Lin Liu, Xiang Cheng, Guo-Ping Shi, Galina K. Sukhova

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842:2174-2183

Cathepsin G (CatG), a serine protease present in mast cells and neutrophils, can produce angiotensin-II (Ang-II) and degrade elastin. Here we demonstrate increased CatG expression in smooth muscle cells (SMCs), endothelial cells (ECs), macrophages, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b4ca7d778d189b841659df81d22c42
https://doi.org/10.1016/j.bbadis.2014.07.026

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Pharmaceutical stabilization of mast cells attenuates experimental atherogenesis in low-density lipoprotein receptor-deficient mice

Autor: Blandine Secco, Jing Wang, Guo-Ping Shi, Sara Sjöberg, Han Chen, Viviane Tia, Min Yang, Galina K. Sukhova

Publikováno v: Atherosclerosis. 229:304-309

Mast cells (MCs) contribute to atherogenesis by releasing pro-inflammatory mediators to activate vascular cells and other inflammatory cells. This study examined whether MC activation or stabilization affects diet-induced atherosclerosis in low-densi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d701bba10d65f081161faa625eac0ff
https://doi.org/10.1016/j.atherosclerosis.2013.05.025

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Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

Autor: Guo-Ping Shi, Peter Libby, Sara Sjöberg, Thomas Reinheckel, Han Chen, Jie Zhang, Galina K. Sukhova, Christoph Peters, Jiusong Sun, Meixiang Xiang, Jian-an Wang

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 31:2500-2508

Objective— The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. Whether this protease partici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e941fdfdf9cba47d03f3fc33c146b5
https://doi.org/10.1161/atvbaha.111.230201

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IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice

Publikováno v: Journal of Clinical Investigation. 128:5184-5184

IgE has a key role in the pathogenesis of allergic responses through its ability to activate mast cells via the receptor FcεR1. In addition to mast cells, many cell types implicated in atherogenesis express FcεR1, but whether IgE has a role in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69df73067cfd559023dcac3aed492364
https://doi.org/10.1172/jci124107

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The Endogenous Estradiol Metabolite 2-Methoxyestradiol Reduces Atherosclerotic Lesion Formation in Female Apolipoprotein E-Deficient Mice

Autor: Sara Sjöberg, J. Bourghardt, Göran Bergström, Åsa Tivesten, Jan Borén, Alexandra Krettek

Publikováno v: Endocrinology. 148:4128-4132

Estradiol, the major endogenous estrogen, reduces experimental atherosclerosis and metabolizes to 2-methoxyestradiol in vascular cells. Currently undergoing evaluation in clinical cancer trials, 2-methoxyestradiol potently inhibits cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7e2118e985aa8c34d54e827b22393b
https://doi.org/10.1210/en.2007-0259

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Augmented levels of CD44 in macrophages from atherosclerotic subjects: A possible IL-6–CD44 feedback loop?

Autor: Lena M. S. Carlsson, Björn Fagerberg, Jan Borén, Lillemor Mattsson Hultén, Daniel Hägg, Olov Wiklund, Annika Rosengren, Per-Arne Svensson, Sara Sjöberg, Alexandra Krettek

Publikováno v: Atherosclerosis. 190:291-297

The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557e65d4198c05d189a08b09debe8f5d
https://doi.org/10.1016/j.atherosclerosis.2006.03.020

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Solar light decomposition of DFP on the surface of anatase and rutile TiO2 prepared by hydrothermal treatment of microemulsions

Autor: Sara Sjöberg, A. Mattson, Andrei Kiselev, Anders Palmqvist, Martin Andersson, Lars Österlund, Andrey Shchukarev

Publikováno v: Surface Science. 584:98-105

The photocatalytic decomposition of diisopropylfluorophosphate (DFP) over nanostructured anatase and rutile TiO2 powder was investigated by FTIR and XPS. Upon irradiation with artificial solar light DFP decomposed on both polymorphs as evidenced by F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::782cb46cab35a92510c5d86e5d65deba
https://doi.org/10.1016/j.susc.2005.01.064

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CDH1mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk

Autor: Eva Jandáková, Barbro Werelius, Kari Hemminki, Haixin Lei, Igor Vořechovský, Annika Lindblom, Sima Salahshor, Sara Sjöberg-Margolin

Publikováno v: International Journal of Cancer. 98:199-204

Mutations and diminished expression of the E-cadherin gene (CDH1) have been identified in a number of epithelial malignancies. Although somatic CDH1 mutations were detected in lobular breast cancer with a frequency ranging from 10-56%, CDH1 alteratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::992963d74fc1df8aa5f410ca9e6bb2c6
https://doi.org/10.1002/ijc.10176

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