Raman Evidence of p53-DBD Disorder Decrease upon Interaction with the Anticancer Protein Azurin

Autor: Sara Signorelli, Salvatore Cannistraro, Anna Rita Bizzarri

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 12, p 3078 (2019)

Raman spectroscopy, which is a suitable tool to elucidate the structural properties of intrinsically disordered proteins, was applied to investigate the changes in both the structure and the conformational heterogeneity of the DNA-binding domain (DBD

Externí odkaz: https://doaj.org/article/dcc765d71720454fb57047a45e426384

Technological change and domestic outsourcing

Autor: Clément Malgouyres, Antonin Bergeaud, Sara Signorelli, Clément Mazet-Sonilhac

Publikováno v: OECD Social, Employment and Migration Working Papers.

Domestic outsourcing has grown substantially in developed countries over the past two decades. This paper addresses the question of the technological drivers of this phenomenon by studying the impact of the staggered diffusion of broadband internet i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8152428f3f1801cd4dee7bbc03014503
https://doi.org/10.1787/e3b226da-en

Structural Characterization of the Intrinsically Disordered Protein p53 Using Raman Spectroscopy

Autor: Salvatore Cannistraro, Anna Rita Bizzarri, Sara Signorelli

Publikováno v: Applied Spectroscopy. 71:823-832

The intrinsically disordered protein p53 has attracted a strong interest for its important role in genome safeguarding and potential therapeutic applications. However, its disordered character makes difficult a full characterization of p53 structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4674c70010c7ba6c22a7adc215ca599
https://doi.org/10.1177/0003702816651891

Chirality Switching within an Anionic Cell-Penetrating Peptide Inhibits Translocation without Affecting Preferential Entry

Autor: Sara Signorelli, Craig W. Beattie, Tohru Yamada, Anna Rita Bizzarri, Salvatore Cannistraro

Publikováno v: Molecular Pharmaceutics. 12:140-149

Multiple substitution of d- for l-amino acids decreases the intracellular uptake of cationic cell penetrating peptides (CPP) in a cell line-dependent manner. We show here that a single d-amino acid substitution can decrease the overall uptake of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ee9521f0e4d364c0f4cb1abde31ae3
https://doi.org/10.1021/mp500495u

Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells

Autor: Sara Signorelli, Clara Pleban, Walter Pfaller, Sonia Aydin, Thomas Lechleitner, Michael Joannidis, Paul Jennings, Paul Perco

Publikováno v: American Journal of Physiology : Cell Physiology, 294(2), C543-C554. American Physiological Society
Aydin, S, Signorelli, S, Lechleitner, T, Joannidis, M, Pleban, C, Perco, P, Pfaller, W & Jennings, P 2008, ' Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells ', American Journal of Physiology : Cell Physiology, vol. 294, no. 2, pp. C543-C554 . https://doi.org/10.1152/ajpcell.00307.2007

In the renal cortex the peritubular capillary network and the proximal tubular epithelium cooperate in solute and water reabsorption, secretion, and inflammation. However, the mechanisms by which these two cell types coordinate such diverse functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956706708df7c764f24c07e5c6cafc70
https://doi.org/10.1152/ajpcell.00307.2007