Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Sara Selig"'
Autor:
Tina Damalas, Eamon Penney, Theresa Cullen, Aaron Dibner-Dunlap, Cecelia English, Jacob Gomez, Amanda Sapp, Sara Selig, Staci Sutermaster
Publikováno v:
Frontiers in Digital Health, Vol 6 (2024)
Recent improvements in the accessibility of mapping tools and an increased recognition of the importance of leveraging data to inform public health operations has led to enthusiasm among public health departments to rapidly evolve their ability to an
Externí odkaz:
https://doaj.org/article/bc8ccab04662410c87216db062bd2d87
Autor:
Ankit Verma, Varsha Poondi Krishnan, Francesco Cecere, Emilia D’Angelo, Vincenzo Lullo, Maria Strazzullo, Sara Selig, Claudia Angelini, Maria R. Matarazzo, Andrea Riccio
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1717 (2023)
Parent-of-origin-dependent gene expression of a few hundred human genes is achieved by differential DNA methylation of both parental alleles. This imprinting is required for normal development, and defects in this process lead to human disease. Induc
Externí odkaz:
https://doaj.org/article/6febba4f70fb41b5aed9810d8089762f
Autor:
Liat H. Hartal-Benishay, Esraa Saadi, Shir Toubiana, Lior Shaked, Maya Lalzar, Ossama Abu Hatoum, Sharon Tal, Sara Selig, Liza Barki-Harrington
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Among the main metabolic pathways implicated in cancer cell proliferation are those of cholesterol and fatty acid synthesis, both of which are tightly regulated by sterol regulatory element-binding proteins (SREBPs). SREBPs are activated through spec
Externí odkaz:
https://doaj.org/article/683c88f5eac9466e83038593963da76e
Autor:
Shira Sagie, Shir Toubiana, Stella R. Hartono, Hagar Katzir, Aya Tzur-Gilat, Shany Havazelet, Claire Francastel, Guillaume Velasco, Frédéric Chédin, Sara Selig
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hy
Externí odkaz:
https://doaj.org/article/a6ea7685f09c4013935240ad88a3e9f7
Autor:
Shir Toubiana, Miriam Gagliardi, Mariarosaria Papa, Roberta Manco, Maty Tzukerman, Maria R Matarazzo, Sara Selig
Publikováno v:
eLife, Vol 8 (2019)
DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human DNMT3B disrupt genome-wide DNA methylation patterns and result in ICF syndrome type 1 (ICF1). To study whether normal D
Externí odkaz:
https://doaj.org/article/f01eb2a545ed43209924dc93efd966ed
Publikováno v:
Life, Vol 11, Iss 4, p 278 (2021)
Most human cancers circumvent senescence by activating a telomere length maintenance mechanism, most commonly involving telomerase activation. A minority of cancers utilize the recombination-based alternative lengthening of telomeres (ALT) pathway. T
Externí odkaz:
https://doaj.org/article/9ca423048e9a4dafae68936432173cf5
Autor:
Stephanie K Mewborn, Megan J Puckelwartz, Fida Abuisneineh, John P Fahrenbach, Yuan Zhang, Heather MacLeod, Lisa Dellefave, Peter Pytel, Sara Selig, Christine M Labno, Karen Reddy, Harinder Singh, Elizabeth McNally
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14342 (2010)
Lamins A and C, encoded by the LMNA gene, are filamentous proteins that form the core scaffold of the nuclear lamina. Dominant LMNA gene mutations cause multiple human diseases including cardiac and skeletal myopathies. The nuclear lamina is thought
Externí odkaz:
https://doaj.org/article/df610e50d6a54be183c634a8b9421c6f
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001183 (2010)
The p12 protein is a cleavage product of the Gag precursor of the murine leukemia virus (MLV). Specific mutations in p12 have been described that affect early stages of infection, rendering the virus replication-defective. Such mutants showed normal
Externí odkaz:
https://doaj.org/article/ede85e55819a41e7a0779d571fbf0b32
Autor:
Varsha Poondi Krishnan, Barbara Morone, Shir Toubiana, Monika Krzak, Salvatore Fioriniello, Floriana Della Ragione, Maria Strazzullo, Claudia Angelini, Sara Selig, Maria R. Matarazzo
Publikováno v:
Genome Research. 33:169-183
Bi-allelic hypomorphic mutations inDNMT3Bdisrupt DNA methyltransferase activity and lead to immunodeficiency, centromeric instability, facial anomalies syndrome, type 1 (ICF1). Although several ICF1 phenotypes have been linked to abnormally hypomethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b5f2a775e178a279dac73095873117
https://doi.org/10.1101/gr.276986.122
https://doi.org/10.1101/gr.276986.122
Autor:
John Z. Cao, Chen Itzkovich, Shir Toubiana, Lucy A. Godley, Adi Mory, Kamal Abu Jabal, Nadra Samra, Liran Giladi, Hagit Baris Feldman, Kristian Tveten, Hilde Yttervik, Sara Selig, Karin Weiss, Ilham Morani, Aya Tzur-Gilat
Publikováno v:
Journal of Human Genetics. 66:1101-1112
RBL2/p130, a member of the retinoblastoma family of proteins, is a key regulator of cell division and propagates irreversible senescence. RBL2/p130 is also involved in neuronal differentiation and survival, and eliminating Rbl2 in certain mouse strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e1c0ddb84341a35ad0890ddb060f9d
https://doi.org/10.1038/s10038-021-00931-z
https://doi.org/10.1038/s10038-021-00931-z