Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sara Sdelci"'
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Proteins are often referred to as the workhorses of cells, and their interactions are necessary to facilitate specific cellular functions. Despite the recognition that protein-protein interactions, and thus protein functions, are determined
Externí odkaz:
https://doaj.org/article/25b99862b3d84bc58c7d7088579ab823
Autor:
Etna Abad, Jérémy Sandoz, Gerard Romero, Ivan Zadra, Julia Urgel-Solas, Pablo Borredat, Savvas Kourtis, Laura Ortet, Carlos M. Martínez, Donate Weghorn, Sara Sdelci, Ana Janic
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-25 (2024)
Abstract Background TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, like the recently ide
Externí odkaz:
https://doaj.org/article/05057dea24dc4caab17c91272a5fc686
Autor:
Laura Pascual‐Reguant, Queralt Serra‐Camprubí, Debayan Datta, Damiano Cianferoni, Savvas Kourtis, Antoni Gañez‐Zapater, Chiara Cannatá, Lorena Espinar, Jessica Querol, Laura García‐López, Sara Musa‐Afaneh, Maria Guirola, Anestis Gkanogiannis, Andrea Miró Canturri, Marta Guzman, Olga Rodríguez, Andrea Herencia‐Ropero, Joaquin Arribas, Violeta Serra, Luis Serrano, Tian V Tian, Sandra Peiró, Sara Sdelci
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Triple‐negative breast cancer (TNBC) often develops resistance to single‐agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 synergis
Externí odkaz:
https://doaj.org/article/a9ac7e4ea8d342f3a90f379ec5eb682e
Autor:
Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual‐Reguant, Natalia Pardo‐Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 7, Pp n/a-n/a (2023)
Abstract While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that
Externí odkaz:
https://doaj.org/article/99959834b32e4fb5a1f4c0a860ce238d
Autor:
Sara Sdelci, Stefan Kubicek
Publikováno v:
Bio-Protocol, Vol 7, Iss 13 (2017)
The ubiquitously expressed bromodomain-containing protein 4 (BRD4) is an epigenetic reader, which recruits transcriptional regulatory complexes to acetylated chromatin. Because of its role in enhancing proliferation, BRD4 has become a therapeutic tar
Externí odkaz:
https://doaj.org/article/d26d363101eb4919af1199aa09bb37a7
Autor:
Jung-Ming G. Lin, Savvas Kourtis, Ritobrata Ghose, Natalia Pardo Lorente, Stefan Kubicek, Sara Sdelci
Publikováno v:
Cell Chem Biol.
While it is well known that expression levels of metabolic enzymes regulate the metabolic state of the cell, there is mounting evidence that the converse is also true, that metabolite levels themselves can modulate gene expression via epigenetic modi
Autor:
Laura Pascual-Reguant, Tian V. Tian, Debayan Datta, Damiano Cianferoni, Savvas Kourtis, Antoni Gañez-Zapater, Chiara Cannatá, Queralt Serra-Camprubi, Lorena Espinar, Maria Guirola, Jessica Querol, Andrea Miró Canturri, Joaquin Arribas, Luis Serrano, Sandra Peiró, Sara Sdelci
Publikováno v:
Biorxiv.org (submitted to Cancer Reaserch)
bioRxiv
bioRxiv
Triple-negative breast cancer often develops resistance to single-agent treatments, which can be circumvented with targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 cooperate to reduce triple-n
Autor:
Jung-Ming G. Lin, Christian Schmidl, Hans Michael Maric, Emilio Casanova, Keiryn L. Bennett, Gerald Hofstaetter, André C. Müller, Johannes Zuber, Robert Kralovics, Anna Ringler, Katja Parapatics, Freya Klepsch, Wanhui You, Karl Mechtler, Matthias Farlik, Jörg Menche, André F. Rendeiro, Stefan Kubicek, Sandra Schick, Bettina Guertl, Sara Sdelci, Kristaps Klavins, Michael Schuster, Herwig P. Moll, Christoph Bock, Thomas Penz, Philipp Rathert, Otto Hudecz, James E. Bradner, Georg E. Winter, Shuang-Yan Wang, Fiorella Schischlik, Peter Májek, Pisanu Buphamalai, Matthew Oldach, Richard Imre, Dennis L. Buckley
Publikováno v:
Nature genetics
Nature Genetics
Nature Genetics
The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic an
Autor:
Peter Májek, Richard Imre, Christian Schmidl, Wanhui You, Pisanu Buphamalai, Fiorella Schischlik, Georg E. Winter, Dennis L. Buckley, Otto Hudecz, Stefan Kubicek, Christoph Bock, Bettina Guertl, James E. Bradner, Anna Ringler, Gerald Hofstaetter, Emilio Casanova, Philipp Rathert, Matthias Farlik, André C. Müller, Michael Schuster, Herwig P. Moll, Johannes Zuber, Robert Kralovics, Sara Sdelci, Thomas Penz, Freya Klepsch, Sandra Schick, Kristaps Klavins, Jörg Menche, Karl Mechtler, Matthew Oldach, Keiryn L. Bennett, André F. Rendeiro, Katja Parapatics
The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e8ad8b40de774d9f4b21cc367bb5ed
https://doi.org/10.1101/439422
https://doi.org/10.1101/439422