Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players

Autor: Rubén Corpas, Elisabeth Solana, Adrian De la Rosa, Sara Sarroca, Christian Griñán-Ferré, Mireia Oriol, Emili Corbella, Eduard Rodríguez-Farré, Jose Vina, Mercè Pallàs, David Bartrés-Faz, Mari Carmen Gomez-Cabrera, Coral Sanfeliu

Publikováno v: Frontiers in Aging Neuroscience, Vol 11 (2019)

Physical exercise performed regularly is known to improve health and to reduce the risk of age-related diseases. Furthermore, there is some evidence of cognitive improvement in physically active middle-aged and older adults. We hypothesized that long

Externí odkaz: https://doaj.org/article/a1a340c6d8af45c483dc13cf6d0fc116

p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation

Autor: Mark Slevin, Coral Sanfeliu, Wen Hui Fang, Jerzy Krupinski, Francesca Caccuri, Glenn Ferris, Ria Weston, Donghui Liu, Laura Colombo, Yasmin Zeinolabediny, Sara Sarroca, Arnaldo Caruso, Baoqiang Guo, Xianwei Zeng, Mario Salmona, Rubén Corpas

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

© 2018, United States & Canadian Academy of Pathology. HIV-associated neurocognitive disorder in HIV patients substantially reduces their quality of life. We previously showed that the HIV matrix protein, p17 could stimulate lymph-angiogenesis in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f35dc375b955170b4b75d39b4d53f7d
http://hdl.handle.net/10261/201719

Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production

Autor: Sara Sarroca, Coral Sanfeliu, Rubén Corpas, José A. Esteban, Idoia Garcia, Rocío Palenzuela, Carlos G. Dotti, Ander Matheu, Angel R. Nebreda, Sandra Colié

Publikováno v: DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
Digital.CSIC. Repositorio Institucional del CSIC
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Scientific Reports
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38α to n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33603b2502738bf892eb3e9570ccb04b

Preservation of cell-survival mechanisms by the presenilin-1 K239N mutation may cause its milder clinical phenotype

Autor: Carlos A. Saura, Sara Sarroca, Cristina Aresté, Albert Lladó, Patricia Molina-Martínez, Coral Sanfeliu, Rosa Gasa, José Luis Molinuevo, Martin Etzrodt, Pablo García de Frutos, Raquel Sánchez-Valle, Anna Antonell

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Presenilin 1 (PSEN1) mutations are the main cause of monogenic Alzheimer's disease. We studied the functional effects of the mutation K239N, which shows incomplete penetrance at the age of 65 years and compared it with the more aggressive mutation E1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5976b8b93d6aa04c08eefcb60046194d
https://pubmed.ncbi.nlm.nih.gov/27498054

Monomeric C-reactive protein - A key molecule driving development of Alzheimer's disease associated with brain ischaemia?

Autor: Jurek Krupinski, Susana Revilla, M. A. Font, Donghui Liu, Rubén Corpas, Emhamed Boras, Coral Sanfeliu, Raid Al-Baradie, Yasmin Zeinolabediny, Aurel Popa-Wagner, Mark Slevin, Lawrence A. Potempa, Sabine Matou, Lina Badimon, Sara Sarroca, M. Di Napoli, Seth Love, E. Petcu, Ria Weston

Publikováno v: Scientific Reports
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Digital.CSIC. Repositorio Institucional del CSIC

M. Slevin et al.
Alzheimer's disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, associating with microvasculature, neurons and AD-plaque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85c97ffe8b07e51a54d38140dadb59c
http://hdl.handle.net/10261/124691