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KRIT1 loss-of-function induces a sustained Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: implication for Cerebral Cavernous Malformation disease

Autor: Andrea Perrelli, Eliana Trapani, Cinzia Antognelli, Simona Delle Monache, Claudia Fornelli, Valerio Benedetti, Giulia Costantino, Federica Geddo, Alessia Zotta, Sara Sarri, Giovanna Bratti, Luca Goitre, Saverio Francesco Retta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ac30f9a70f0732a8afa2d3c9c6f59d
http://hdl.handle.net/11391/1453936

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Altered redox homeostasis and signaling in Cerebral Cavernous Malformation disease: towards a complex but unifying pathogenic mechanism and therapeutic implications

Autor: Eliana Trapani, Saverio Francesco Retta, Vincenzo Nicola Talesa, Lorenza Trabalzini, Cinzia Antognelli, Andrea Perrelli, Giuseppina Barrera, Sara Sarri, Luca Goitre

Cerebral Cavernous Malformation (CCM) is a major cerebrovascular disease of genetic origin affecting 0.3-0.5% of the population and still awaiting therapies other than neurosurgery. It is characterized by abnormally enlarged and leaky capillaries, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91faea31c8d4bad57d5d2a31692fc73d
http://hdl.handle.net/2318/1723206

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