Výsledky vyhledávání - "Sara Sannino"

Akademický článek

Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

Autor: Satoshi Watanabe, Yuta Amagai, Sara Sannino, Tiziana Tempio, Tiziana Anelli, Manami Harayama, Shoji Masui, Ilaria Sorrentino, Momo Yamada, Roberto Sitia, Kenji Inaba

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrati

Externí odkaz: https://doaj.org/article/af4ed761dc184e4d9ee05ac87e0596a8

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Akademický článek

Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

Autor: Sara Sannino, Megan E Yates, Mark E Schurdak, Steffi Oesterreich, Adrian V Lee, Peter Wipf, Jeffrey L Brodsky

Publikováno v: eLife, Vol 10 (2021)

Molecular chaperones, such as Hsp70, prevent proteotoxicity and maintain homeostasis. This is perhaps most evident in cancer cells, which overexpress Hsp70 and thrive even when harboring high levels of misfolded proteins. To define the response to pr

Externí odkaz: https://doaj.org/article/28e1a0e451824530985dbf869cbc89c6

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Akademický článek

Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, pro

Externí odkaz: https://doaj.org/article/0e5f124f37b14a83811e7cceee5dc56c

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Akademický článek

Targeting protein quality control pathways in breast cancer

Autor: Sara Sannino, Jeffrey L. Brodsky

Publikováno v: BMC Biology, Vol 15, Iss 1, Pp 1-20 (2017)

Abstract The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilita

Externí odkaz: https://doaj.org/article/3b28fb15549f4abea39d3feb005ab59e

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Akademický článek

Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

In the original version of this Article, references in the Methods section incorrectly referred to references in the Supplementary References section. The relevant references (now numbered 20, 27, 42, 47, 69–80) have been removed from the Supplemen

Externí odkaz: https://doaj.org/article/b9def1781218440784dceee7ac28fc40

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Akademický článek

A dynamic study of protein secretion and aggregation in the secretory pathway.

Autor: Maria Francesca Mossuto, Sara Sannino, Davide Mazza, Claudio Fagioli, Milena Vitale, Edgar Djaha Yoboue, Roberto Sitia, Tiziana Anelli

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108496 (2014)

Precise coordination of protein biogenesis, traffic and homeostasis within the early secretory compartment (ESC) is key for cell physiology. As a consequence, disturbances in these processes underlie many genetic and chronic diseases. Dynamic imaging

Externí odkaz: https://doaj.org/article/72fb1d2daa0945caa97c95d3f03e024b

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Akademický článek

Automatic visual tracking and social behaviour analysis with multiple mice.

Autor: Luca Giancardo, Diego Sona, Huiping Huang, Sara Sannino, Francesca Managò, Diego Scheggia, Francesco Papaleo, Vittorio Murino

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74557 (2013)

Social interactions are made of complex behavioural actions that might be found in all mammalians, including humans and rodents. Recently, mouse models are increasingly being used in preclinical research to understand the biological basis of social-r

Externí odkaz: https://doaj.org/article/070a96cc41084215a6c2b78edd8da095

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Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress

Autor: Sara Sannino, Allison M. Manuel, Chaowei Shang, Stacy G. Wendell, Peter Wipf, Jeffrey L. Brodsky

Publikováno v: Molecular Cancer Research. :OF1-OF16

Protein homeostasis (proteostasis) regulates tumor growth and proliferation when cells are exposed to proteotoxic stress, such as during treatment with certain chemotherapeutics. Consequently, cancer cells depend to a greater extent on stress signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6906c896b3a07e13db07eadde79768c2
https://doi.org/10.1158/1541-7786.mcr-22-0843

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Data from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress

Autor: Jeffrey L. Brodsky, Peter Wipf, Stacy G. Wendell, Chaowei Shang, Allison M. Manuel, Sara Sannino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b692918103c4734fc7c8990d7ff5df3
https://doi.org/10.1158/1541-7786.c.6606926

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