Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sara S. Kumar"'
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103198- (2023)
Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription
Externí odkaz:
https://doaj.org/article/f8c9135c166d4e149878ad04c97721c5
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103098- (2023)
Trisomy 21 (T21), or Down Syndrome (DS), is a common chromosomal disorder resulting from a third copy of chromosome 21 (HSA21). Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with DS and is charac
Externí odkaz:
https://doaj.org/article/73cd3e20091c4146a0f8182ed8754a79
Autor:
Wei Wen Teo, Xinang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou, Chong Gao, Kim Vanuytsel, Sara S. Kumar, George J. Murphy, Henry Yang, Li Chai, Daniel G. Tenen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Identification of a long non-coding RNA LEVER, that inhibits the Polycomb Repressive Complex 2 (PRC2) and controls nearby embryonic form of beta-globin gene, provides additional evidence for PRC2-RNA functional interaction.
Externí odkaz:
https://doaj.org/article/c0033e53f61b43739e86a5b844cef74f
Autor:
Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Dylan Parsons, Evan C. Lam, Taylor M. Matte, Todd W. Dowrey, Sara S. Kumar, Mengze Li, Feiya Wang, Anthony K. Yeung, Gustavo Mostoslavsky, Ruben Dries, Joshua D. Campbell, Anna C. Belkina, Alejandro B. Balazs, George J. Murphy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular sign
Externí odkaz:
https://doaj.org/article/cac11a57fa10405ca22f6fddb6df2365
Autor:
Wei Wen Teo, Xinang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou, Chong Gao, Kim Vanuytsel, Sara S. Kumar, George J. Murphy, Henry Yang, Li Chai, Daniel G. Tenen
Publikováno v:
Communications biology. 5(1)
Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA interaction has been controversial. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febaaf4e384588989fcbb7090f5dcf1d
https://pubmed.ncbi.nlm.nih.gov/35411071
https://pubmed.ncbi.nlm.nih.gov/35411071
Autor:
Kim, Vanuytsel, Carlos, Villacorta-Martin, Jonathan, Lindstrom-Vautrin, Zhe, Wang, Wilfredo F, Garcia-Beltran, Vladimir, Vrbanac, Dylan, Parsons, Evan C, Lam, Taylor M, Matte, Todd W, Dowrey, Sara S, Kumar, Mengze, Li, Feiya, Wang, Anthony K, Yeung, Gustavo, Mostoslavsky, Ruben, Dries, Joshua D, Campbell, Anna C, Belkina, Alejandro B, Balazs, George J, Murphy
Publikováno v:
Nature communications. 13(1)
The human hematopoietic stem cell harbors remarkable regenerative potential that can be harnessed therapeutically. During early development, hematopoietic stem cells in the fetal liver undergo active expansion while simultaneously retaining robust en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf6c6184e32bcf61ee026aef78f80a8e
https://pubmed.ncbi.nlm.nih.gov/35232959
https://pubmed.ncbi.nlm.nih.gov/35232959
Autor:
George J. Murphy, Anna C. Belkina, Carlos Villacorta-Martin, Todd W. Dowrey, Alejandro B. Balazs, Zhe Wang, Kim Vanuytsel, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Taylor Matte, Sara S. Kumar, Joshua D. Campbell, Mengze Li, Jonathan Lindstrom-Vautrin, Ruben Dries
SUMMARYThe human hematopoietic stem cell (HSC) harbors remarkable regenerative potential that can be harnessed therapeutically. During early development, HSCs in the fetal liver (FL) undergo active expansion while simultaneously retaining robust engr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9602f3f71b4216ba15daa700c4243d2
https://doi.org/10.1101/2020.11.11.378620
https://doi.org/10.1101/2020.11.11.378620
Autor:
Steinberg MH; Department of Medicine, Division of Hematology/Oncology, Center of Excellence for Sickle Cell Disease and Center for Regenerative Medicine, Boston University School of Medicine and Boston Medical Center, Boston MA., Kumar S; Department of Medicine, Division of Hematology/Oncology, Center of Excellence for Sickle Cell Disease and Center for Regenerative Medicine, Boston University School of Medicine and Boston Medical Center, Boston MA., Murphy GJ; Department of Medicine, Division of Hematology/Oncology, Center of Excellence for Sickle Cell Disease and Center for Regenerative Medicine, Boston University School of Medicine and Boston Medical Center, Boston MA., Vanuytsel K; Department of Medicine, Division of Hematology/Oncology, Center of Excellence for Sickle Cell Disease and Center for Regenerative Medicine, Boston University School of Medicine and Boston Medical Center, Boston MA.
Publikováno v:
Expert review of precision medicine and drug development [Expert Rev Precis Med Drug Dev] 2019; Vol. 4 (6), pp. 357-367. Date of Electronic Publication: 2019 Nov 07.