Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sara S Parker"'
Autor:
Samantha M. Hill, Marco Padilla-Rodriguez, Amber Clements, Jillian A. Sweetland, Sara S. Parker, Noel A. Warfel, Ghassan Mouneimne
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101516- (2022)
Summary: We describe a three-dimensional (3D) in vitro assay for quantifying cancer cell invasion into a 3D microenvironment with defined biochemical and biophysical properties. Researchers can quantify invasion dynamics (e.g., cell motility and dire
Externí odkaz:
https://doaj.org/article/d4a2f898fbff4970963b6c7795003d51
Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH
Autor:
Theresa Hwang, Sara S Parker, Samantha M Hill, Robert A Grant, Meucci W Ilunga, Venkatesh Sivaraman, Ghassan Mouneimne, Amy E Keating
Publikováno v:
eLife, Vol 11 (2022)
The human proteome is replete with short linear motifs (SLiMs) of four to six residues that are critical for protein-protein interactions, yet the importance of the sequence surrounding such motifs is underexplored. We devised a proteomic screen to e
Externí odkaz:
https://doaj.org/article/8d2a3a0e6b2f42ec9501ad4f27397441
Autor:
Theresa Hwang, Sara S Parker, Samantha M Hill, Meucci W Ilunga, Robert A Grant, Ghassan Mouneimne, Amy E Keating
Publikováno v:
eLife, Vol 10 (2021)
Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site. A proteome-wide scr
Externí odkaz:
https://doaj.org/article/85b0b8918f554dc58611c73b71fa31cd
Autor:
Adam W. Watson, Adam D. Grant, Sara S. Parker, Samantha Hill, Michael B. Whalen, Jayati Chakrabarti, Michael W. Harman, Mackenzie R. Roman, Brittany L. Forte, Cody C. Gowan, Raúl Castro-Portuguez, Lindsey K. Stolze, Christian Franck, Darren A. Cusanovich, Yana Zavros, Megha Padi, Casey E. Romanoski, Ghassan Mouneimne
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109293- (2021)
Summary: While the immediate and transitory response of breast cancer cells to pathological stiffness in their native microenvironment has been well explored, it remains unclear how stiffness-induced phenotypes are maintained over time after cancer c
Externí odkaz:
https://doaj.org/article/9120a5dd6d85476791e874d67897611c
Autor:
Marco Padilla-Rodriguez, Sara S. Parker, Deanna G. Adams, Thomas Westerling, Julieann I. Puleo, Adam W. Watson, Samantha M. Hill, Muhammad Noon, Raphael Gaudin, Jesse Aaron, Daoqin Tong, Denise J. Roe, Beatrice Knudsen, Ghassan Mouneimne
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Whilst estrogen is known to be tumorigenic in some breast cancer, in some contexts it can be protective against invasion and dissemination. Here, the authors show estrogen can promote generation of Suppressive Cortical Actin Bundles that can inhibit
Externí odkaz:
https://doaj.org/article/46283693eda645978c7dcb8a878cd28b
Autor:
Sara S. Parker, Kenneth Tran Ly, Adam D. Grant, Jillian Sweetland, Ashley M. Wang, James D. Parker, Mackenzie R. Roman, Kathylynn Saboda, Denise J. Roe, Megha Padi, Charles W. Wolgemuth, Paul Langlais, Ghassan Mouneimne
Publikováno v:
Journal of Cell Biology. 222
Dendritic spines are the postsynaptic compartment of a neuronal synapse and are critical for synaptic connectivity and plasticity. A developmental precursor to dendritic spines, dendritic filopodia (DF), facilitate synapse formation by sampling the e
Autor:
Sara S. Parker, Robert A. Grant, Theresa Hwang, Amy E. Keating, Samantha M. Hill, Meucci W. Ilunga, Ghassan Mouneimne
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100% conserved binding site. A proteome-wide scre
Autor:
Megha Padi, Wang Am, Ghassan Mouneimne, Parker Jd, Ly Kt, Charles W. Wolgemuth, Mackenzie R. Roman, Paul R. Langlais, Sara S. Parker, Adam D. Grant
Dendritic spines are the postsynaptic compartment of a functional neuronal synapse, and are critical for synaptic connectivity and plasticity. The developmental precursor to dendritic spines, dendritic filopodia, are highly motile protrusions that fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a608162f2f7b18e10b5aebf6409a17
https://doi.org/10.1101/2021.05.26.444586
https://doi.org/10.1101/2021.05.26.444586
Autor:
Adam W. Watson, Leilei Peng, Denise J. Roe, Julieann I. Puleo, Kathylynn Saboda, Robert Ros, Ghassan Mouneimne, Frank B. Gertler, Sara S. Parker, Mackenzie R. Roman, Kiarash Rahmani Eliato
Publikováno v:
The Journal of Cell Biology
Puleo et al. identify the Ena/VASP protein EVL as a crucial actin polymerization factor at focal adhesions, which regulates focal adhesion maturation and mechanosensing. Interestingly, they show that EVL promotes mechanically directed motility and du