Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sara S, Hook"'
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer- related deaths. PDAC remains one of the most difficult-to-treat cancers, owing to its unique pathobiological features: a nearly impenetrable desmoplastic stroma, and hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151d2a3b32c68e13650dfacb8a882852
https://zenodo.org/record/1233511
https://zenodo.org/record/1233511
Autor:
Dorothy Farrell, Sandra Chapman, Piotr Grodzinski, Krzysztof Ptak, Nicholas J. Panaro, George W. Hinkal, Sara S. Hook, Uma Prabhakar
Publikováno v:
Nanomedicine. 7:321-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aca936b5cdee4e6a2f3f6701be7b05b
https://doi.org/10.2217/nnm.12.13
https://doi.org/10.2217/nnm.12.13
Publikováno v:
Current Opinion in Cell Biology. 19:663-671
Recent advances in the replication field have highlighted how the replication initiator proteins are negatively regulated by inhibitor proteins and ubiquitin-mediated degradation in mammalian cells to prevent rereplication. When these regulatory path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cc2669969ddc292ff1f3c770eca7f5
https://doi.org/10.1016/j.ceb.2007.10.007
https://doi.org/10.1016/j.ceb.2007.10.007
Publikováno v:
Proceedings of the National Academy of Sciences. 99:13425-13430
Histone deacetylases (HDACs) are thought to function as critical mediators of transcriptional repression. However, the physiological targets and posttranslational modifications of the class II HDACs are largely unknown. Here we show that the C termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195239e833924a6c73542674bd67e2c4
https://doi.org/10.1073/pnas.172511699
https://doi.org/10.1073/pnas.172511699
Autor:
Anthony R. Means, Sara S. Hook
Publikováno v:
Annual Review of Pharmacology and Toxicology. 41:471-505
Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca2+. The Ca2+/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca2+/CaM-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2916797538f002aea62fd07c5ab4402
https://doi.org/10.1146/annurev.pharmtox.41.1.471
https://doi.org/10.1146/annurev.pharmtox.41.1.471
Autor:
Sara S. Hook, Justin Hanes, Jennifer B Hall, Fatih M. Uckun, Jeff W.M. Bulte, Andrew Z. Wang, Anil K. Patri, Russell J. Mumper, Demir Akin, Nastaran Gharkholo, Michael S. Goldberg, Vincent L. Cryns
Biotargeted nanomedicines have captured the attention of academic and industrial scientists who have been motivated by the theoretical possibilities of the ‘magic bullet’ that was first conceptualized by Paul Ehrlich at the beginning of the 20th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844c31432aff71a200df995cc833742f
Autor:
Sara S. Hook, Arthur M. Edelman, Elaine G. Goldstein, David Stapleton, Bruce E. Kemp, Ken I. Mitchelhill, Anthony R. Means, Kristin A. Anderson, Michele A. Selbert
Publikováno v:
Journal of Biological Chemistry. 271:10806-10810
We have purified to near homogeneity from rat brain two Ca-calmodulin-dependent protein kinase I (CaM kinase I) activating kinases, termed here CaM kinase I kinase-α and CaM kinase I kinase-β (CaMKIKα and CaMKIKβ, respectively). Both CaMKIKα and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eac006ca42fba25dbde482b30dfa738
https://doi.org/10.1074/jbc.271.18.10806
https://doi.org/10.1074/jbc.271.18.10806
Autor:
E G Goldstein, Ralph Snyderman, Sara S. Hook, Bodduluri Haribabu, Arthur M. Edelman, Anthony R. Means, M A Selbert, Eric D. Tomhave
Publikováno v:
The EMBO Journal. 14:3679-3686
Human Ca(2+)-calmodulin (CaM) dependent protein kinase I (CaMKI) encodes a 370 amino acid protein with a calculated M(r) of 41,337. The 1.5 kb CaMKI mRNA is expressed in many different human tissues and is the product of a single gene located on huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948d1f84377858f7abc563f7b64b07d4
https://doi.org/10.1002/j.1460-2075.1995.tb00037.x
https://doi.org/10.1002/j.1460-2075.1995.tb00037.x
Autor:
Sandra, Chapman, Nicholas J, Panaro, George W, Hinkal, Sara S, Hook, Uma, Prabhakar, Krzysztof, Ptak, Dorothy, Farrell, Piotr, Grodzinski
Publikováno v:
Nanomedicine (London, England). 7(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8618c0bc123d8debe17c199c0e13166f
https://pubmed.ncbi.nlm.nih.gov/22385196
https://pubmed.ncbi.nlm.nih.gov/22385196