Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sara Rodriguez-Acebes"'
Publikováno v:
Cells, Vol 13, Iss 2, p 159 (2024)
The regulated formation and resolution of R-loops is a natural process in physiological gene expression. Defects in R-loop metabolism can lead to DNA replication stress, which is associated with a variety of diseases and, ultimately, with cancer. The
Externí odkaz:
https://doaj.org/article/1316b9e396d14d2ca552216d376e41f5
Autor:
Andres J. Lopez-Contreras, Isabel Ruppen, Maria Nieto-Soler, Matilde Murga, Sara Rodriguez-Acebes, Silvia Remeseiro, Sara Rodrigo-Perez, Ana M. Rojas, Juan Mendez, Javier Muñoz, Oscar Fernandez-Capetillo
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1105-1116 (2013)
DNA replication is facilitated by multiple factors that concentrate in the vicinity of replication forks. Here, we developed an approach that combines the isolation of proteins on nascent DNA chains with mass spectrometry (iPOND-MS), allowing a compr
Externí odkaz:
https://doaj.org/article/a109e633654249909b199aa063cf4c58
Autor:
Gareth H. Williams, Kai Stoeber, Jonathan A. Ledermann, Andrew T. Prevost, Sara Rodriguez-Acebes, Mohammed Rashid, Marco Loddo, Hye-Kyung Hong, Slavica Tudzarova, Sarah R. Kingsbury, Anjana A. Kulkarni
Supplementary Data from Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a500006f8c48198a4dd368bef5162a
https://doi.org/10.1158/1078-0432.22440664
https://doi.org/10.1158/1078-0432.22440664
Autor:
Gareth H. Williams, Kai Stoeber, Jonathan A. Ledermann, Andrew T. Prevost, Sara Rodriguez-Acebes, Mohammed Rashid, Marco Loddo, Hye-Kyung Hong, Slavica Tudzarova, Sarah R. Kingsbury, Anjana A. Kulkarni
Purpose: There is a lack of prognostic and predictive biomarkers in epithelial ovarian carcinoma, and the targeting of oncogenic signaling pathways has had limited impact on patient survival in this highly heterogeneous disease. The origin licensing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2fb0d454201b066c3c766645859ed4
https://doi.org/10.1158/1078-0432.c.6517963.v1
https://doi.org/10.1158/1078-0432.c.6517963.v1
Autor:
Vanesa Lafarga, Carmen Morales, Diego Megías, Miriam Rodríguez-Corsino, Jan-Michael Peters, Juan Méndez, Sara Rodriguez-Acebes, Miguel Ruiz-Torres, David A. Cisneros, Ana Losada
Publikováno v:
The Journal of Biological Chemistry
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cohesin is a chromatin-bound complex that mediates sister chromatid cohesion and facilitates long-range interactions through DNA looping. How the transcription and replication machineries deal with the presence of cohesin on chromatin remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67086a02cf7e4182037089e1daeac554
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174302
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174302
Autor:
Andrés J. López-Contreras, Marius Bruer, Katharina Haneke, Sylvia Erhardt, Lea Roessig, Hsu Min Sung, Georg Stoecklin, Anne Laure Pauleau, Vanesa Lafarga, Sara Rodriguez-Acebes, Juan Méndez, Oscar Fernandez-Capetillo, Oliver J. Gruss
Publikováno v:
Lafarga, V, Sung, H-M, Haneke, K, Roessig, L, Pauleau, A-L, Bruer, M, Rodriguez-Acebes, S, Lopez-Contreras, A J, Gruss, O J, Erhardt, S, Mendez, J, Fernandez-Capetillo, O & Stoecklin, G 2019, ' TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress ', EMBO Reports, vol. 20, no. 1, e46224 . https://doi.org/10.15252/embr.201846224
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
The G2/M checkpoint coordinates DNA replication with mitosis and thereby prevents chromosome segregation in the presence of unreplicated or damaged DNA Here, we show that the RNA-binding protein TIAR is essential for the G2/M checkpoint and that TIAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce61c87182cf6208a4ea8463b1016bc
https://doi.org/10.15252/embr.201846224
https://doi.org/10.15252/embr.201846224
Autor:
Oscar Fernandez-Capetillo, Isabel Ruppen, Sara Rodriguez-Acebes, Javier Muñoz, Matilde Murga, Emilio Lecona, Julia Specks, Juan Méndez, Andrés J. López-Contreras
Publikováno v:
Nature Structural & Molecular Biology. 23:270-277
Post-translational modification of proteins by ubiquitin (Ub) and Ub-like modifiers regulates various aspects of DNA replication. We previously showed that the chromatin around replisomes is rich in SUMO and depleted in Ub, whereas an opposite patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493c0f01ceb1fdeae3420c0fc1516654
https://doi.org/10.1038/nsmb.3185
https://doi.org/10.1038/nsmb.3185
Autor:
Tania López‐Briones, Daniel González-Acosta, Ignacio Moreno de Alborán, Alfonsina Trento, Sara Rodriguez-Acebes, Sara Roman-Garcia, Carlos Torroja, Mercedes Pérez‐Olivares, Juan Méndez, Dolores Martinez, David Fernandez-Antoran, Yolanda R. Carrasco
Publikováno v:
EMBO reports. 19
The Myc family of oncogenic transcription factors regulates myriad cellular functions. Myc proteins contain a basic region/helix‐loop‐helix/leucine zipper domain that mediates DNA binding and heterodimerization with its partner Max. Among the Myc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07187ccf4c18782af598103c9a3f71a4
https://doi.org/10.15252/embr.201845770
https://doi.org/10.15252/embr.201845770
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
The Journal of Biological Chemistry
Instituto de Salud Carlos III (ISCIII)
The Journal of Biological Chemistry
In growing cells, DNA replication precedes mitotic cell division to transmit genetic information to the next generation. The slowing or stalling of DNA replication forks at natural or exogenous obstacles causes "replicative stress" that promotes geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bb7058d0acdcb4919b2d0a055b1ec7
https://hdl.handle.net/20.500.12105/8366
https://hdl.handle.net/20.500.12105/8366
Autor:
Matilde Murga, Juan Méndez, Federica Schiavoni, Sara Rodriguez-Acebes, Paula Martinez, Maria A. Blasco, Enrico Tenaglia, Oscar Fernandez-Capetillo, Paula Gutierrez-Martinez, Ariana Jacome, Emilio Lecona
Publikováno v:
The EMBO Journal. 34:2604-2619
The SMC5/6 complex is the least understood of SMC complexes. In yeast, smc5/6 mutants phenocopy mutations in sgs1, the BLM ortholog that is deficient in Bloom's syndrome (BS). We here show that NSMCE2 (Mms21, in Saccharomyces cerevisiae), an essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06c72e5cfe7e8920baf63eac0bf4d2c
https://doi.org/10.15252/embj.201591829
https://doi.org/10.15252/embj.201591829