Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sara Rodríguez-Acebes"'
Autor:
Sergio Muñoz, Sabela Búa, Sara Rodríguez-Acebes, Diego Megías, Sagrario Ortega, Alba de Martino, Juan Méndez
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 928-938 (2017)
Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DN
Externí odkaz:
https://doaj.org/article/41b899ad15f3460ba2efdedc9f9d60af
Autor:
Santiago Hernández-Pérez, Elisa Cabrera, Hugo Amoedo, Sara Rodríguez-Acebes, Stephane Koundrioukoff, Michelle Debatisse, Juan Méndez, Raimundo Freire
Publikováno v:
Molecular Oncology, Vol 10, Iss 8, Pp 1196-1206 (2016)
DNA replication control is a key process in maintaining genomic integrity. Monitoring DNA replication initiation is particularly important as it needs to be coordinated with other cellular events and should occur only once per cell cycle. Crucial pla
Externí odkaz:
https://doaj.org/article/77d7e8ffcbcd4be680be513156e9b11a
Autor:
Maud Debaugnies, Sara Rodríguez-Acebes, Jeremy Blondeau, Marie-Astrid Parent, Manuel Zocco, Yura Song, Viviane de Maertelaer, Virginie Moers, Mathilde Latil, Christine Dubois, Katia Coulonval, Francis Impens, Delphi Van Haver, Sara Dufour, Akiyoshi Uemura, Panagiota A. Sotiropoulou, Juan Méndez, Cédric Blanpain
Publikováno v:
Nature
ISSN
ISSN
The resistance of cancer cells to therapy is responsible for the death of most patients with cancer1. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to therapy in different cancer cells2,3. However, the mechanisms by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc8750161131a7283ca776ea4412628
https://biblio.ugent.be/publication/01H63DN1T31XZA6G285HZY4B8C
https://biblio.ugent.be/publication/01H63DN1T31XZA6G285HZY4B8C
Autor:
Karolina Jodkowska, Vera Pancaldi, Maria Rigau, Ricardo Almeida, José M Fernández-Justel, Osvaldo Graña-Castro, Sara Rodríguez-Acebes, Miriam Rubio-Camarillo, Enrique Carrillo-de Santa Pau, David Pisano, Fátima Al-Shahrour, Alfonso Valencia, María Gómez, Juan Méndez
Publikováno v:
Nucleic acids research. 50(21)
In mammalian cells, chromosomal replication starts at thousands of origins at which replisomes are assembled. Replicative stress triggers additional initiation events from ‘dormant’ origins whose genomic distribution and regulation are not well u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770fabffe6954bc70003fd6e82599e07
https://pubmed.ncbi.nlm.nih.gov/36453993
https://pubmed.ncbi.nlm.nih.gov/36453993
Autor:
Sara Rodríguez-Acebes, Rodrigo Martín-Rufo, Alejandro Fernández-Llorente, Guillermo de la Vega-Barranco, Pilar Oroz, Elena Martín-Doncel, Luis Ignacio Toledo, Juan Méndez, Emilio Lecona
The replication stress response is an essential pathway that deals with the lesions that halt the progression of DNA replication forks even during an unperturbed S phase. Basal activation of the ATR and CHK1 kinases prevents the premature firing of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8e1651c47ea54a8258b11bfc5f3b00
https://doi.org/10.1101/2022.07.25.501345
https://doi.org/10.1101/2022.07.25.501345
Autor:
Arnau Ulsamer, Adrián Martínez-Limón, Sina Bader, Sara Rodríguez-Acebes, Raimundo Freire, Juan Méndez, Eulàlia de Nadal, Francesc Posas
Stress-activated protein kinases (SAPKs) enhance survival in response to environmental changes. In yeast, the Hog1 SAPK and Mrc1, a protein required for DNA replication, define a safeguard mechanism that allows eukaryotic cells to prevent genomic ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7934b2cbbd7313e9d091facd755cce3
http://hdl.handle.net/10230/54827
http://hdl.handle.net/10230/54827
Publikováno v:
Cells, Vol 13, Iss 2, p 159 (2024)
The regulated formation and resolution of R-loops is a natural process in physiological gene expression. Defects in R-loop metabolism can lead to DNA replication stress, which is associated with a variety of diseases and, ultimately, with cancer. The
Externí odkaz:
https://doaj.org/article/1316b9e396d14d2ca552216d376e41f5
Autor:
Javier Martínez-Botas, Miguel A. Lasunción, Antonio J. Ferruelo, Diego Gómez-Coronado, Carlos Fernández-Hernando, Sara Rodríguez-Acebes, Paloma de la Cueva
Publikováno v:
Biochemical and Biophysical Research Communications. 377:484-488
We addressed the ability of native, oxidized and acetylated low-density lipoproteins (nLDL, oxLDL and acLDL, respectively) and desmosterol to act as sources of sterol for the proliferation of J774A.1 macrophages. Treatment with 0.5 microM lovastatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0c32a12ef6a95db3a59d71f0bbef2b
https://doi.org/10.1016/j.bbrc.2008.09.140
https://doi.org/10.1016/j.bbrc.2008.09.140
Autor:
Javier Martínez-Botas, Covadonga Martín Sánchez, Jong-Sik Jin, Gema de la Peña, Miguel A. Lasunción, M.J. Hazen, Yajaira Suárez, Wei Zhang, José Manuel Pérez Martín, Sara Rodríguez-Acebes, Alberto Dávalos, Diego Gómez-Coronado, Yung-Chi Cheng, Rebeca Busto
Publikováno v:
Biochimica et biophysica acta. 1851(9)
The mevalonate pathway is tightly linked to cell division. Mevalonate derived non-sterol isoprenoids and cholesterol are essential for cell cycle progression and mitosis completion respectively. In the present work, we studied the effects of fluorome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0379e4daff0bf5effe9ab29e325c4c51
https://pubmed.ncbi.nlm.nih.gov/26055626
https://pubmed.ncbi.nlm.nih.gov/26055626
Autor:
Lidia A. Daimiel, María E. Fernández‑Suárez, Sara Rodríguez‑Acebes, Lorena Crespo, Miguel A. Lasunción, Diego Gómez‑Coronado, Javier Martínez‑Botas
Publikováno v:
Bioscience Reports, Vol 33, Iss 1, p e00006 (2012)
DHCR24 (3β-hydroxysterol Δ24-reductase) catalyses the reduction of the C-24 double bond of sterol intermediates during cholesterol biosynthesis. DHCR24 has also been involved in cell growth, senescence and cellular response to oncogenic and oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::ebae4f4c572d677456e8438349882370
http://www.bioscirep.org/bsr/033/e006/bsr033e006.htm
http://www.bioscirep.org/bsr/033/e006/bsr033e006.htm