Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sara Rao"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107151 (2014)
The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin. TRPM8 ma
Externí odkaz:
https://doaj.org/article/bda35a7371e041359f6ffa57a92865c1
Autor:
Dawn Weishuhn, Simone Brioschi, Diana Cha, Marco Colonna, Daniel Yoo, Sara Rao, Samuel A. Hasson, Jodi Bradley, Peng Luan, Ian Foltz, Shilpa Sambashivan, Shoutang Wang, Daniel C. Ellwanger, Menno Van Lookeren Campagne, Susan Gilfillan, Palaniswami Rathanaswami, Ryan Case, Lydia Green, Zhifei Shao
Publikováno v:
Proc Natl Acad Sci U S A
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ). Alzheimer’s disease (AD) risk is associated with the TREM2(R47H) variant, w
Publikováno v:
Critical Care Medicine. 42:A1430-A1431
Publikováno v:
Molecular Pain, Vol 8, Iss 1, p 36 (2012)
Molecular Pain
Molecular Pain
Background: Transient receptor potential cation channel subfamily M member 8 (TRPM8) is activated by cold temperature in vitro and has been demonstrated to act as a ‘cold temperature sensor’ in vivo. Although it is known that agonists of this ‘
Autor:
Michael F. Gardner, Xiaoqing Yang, Janice Chung, Jesse Brodkin, Jean Michel Vernier, Jeffery J. Anderson, Xiaohui Jiang, Bowei Wang, Sara Rao, Benito Munoz
Publikováno v:
Bioorganicmedicinal chemistry. 12(1)
A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored. A
Autor:
Margaret J. Bradbury, Greg Holtz, Sara Rao, Mark A. Varney, Darlene R. Giracello, Jeffery J. Anderson, Deborah F. Chapman, H. Schaffhauser
Publikováno v:
Neuropharmacology. 44(5)
The mGluR5 antagonist 2-methyl-6-(phenylethynyl) pyridine (MPEP) produces anxiolytic or antidepressant effects in several rodent models through incompletely described mechanisms. Anxiolytics and antidepressants share several neuroendocrine features,
Autor:
Jesse Brodkin, Jeffrey Roger Roppe, Linda J. Bristow, Jeffrey Anderson, Edwin J. Schweiger, Lida Tehrani, Mark S. Washburn, Ian A. McDonald, Sara Rao, Xiaohui Jiang, Nicholas D. P. Cosford, Mark A. Varney, Nicholas D. Smith
Publikováno v:
Journal of medicinal chemistry. 46(2)
2-Methyl-6-(phenylethynyl)pyridine (3), a potent noncompetitive mGlu5 receptor antagonist widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of shortcomings as a therapeutic agent, including off-target activity and
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107151 (2014)
PLoS ONE
PLoS ONE
The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin. TRPM8 ma
Autor:
Miller, Silke1, Rao, Sara1, Wang, Weiya1, Liu, Hantao1, Wang, Judy1, Gavva, Narender R.1 ngavva@amgen.com
Publikováno v:
PLoS ONE. Sep2014, Vol. 9 Issue 9, p1-10. 10p.
Autor:
Lehto, Sonya, Weyer, Andy, Zhang, Maosheng, Youngblood, Beth, Wang, Judy, Wang, Weiya, Kerstein, Patrick, Davis, Carl, Wild, Kenneth, Stucky, Cheryl, Gavva, Narender
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology; Apr2015, Vol. 388 Issue 4, p465-476, 12p