Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sara Ranjbarvaziri"'
Autor:
Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A. Mandegar, Timothy Hoey, Jin Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a gen
Externí odkaz:
https://doaj.org/article/9658610d4ff04dbaabe514860e2f248f
Autor:
Francis Grafton, Jaclyn Ho, Sara Ranjbarvaziri, Farshad Farshidfar, Anastasiia Budan, Stephanie Steltzer, Mahnaz Maddah, Kevin E Loewke, Kristina Green, Snahel Patel, Tim Hoey, Mohammad Ali Mandegar
Publikováno v:
eLife, Vol 10 (2021)
Drug-induced cardiotoxicity and hepatotoxicity are major causes of drug attrition. To decrease late-stage drug attrition, pharmaceutical and biotechnology industries need to establish biologically relevant models that use phenotypic screening to dete
Externí odkaz:
https://doaj.org/article/ac40721906f04a0b8947457bd4ad3670
Autor:
Konstantina-Ioanna Sereti, Ngoc B. Nguyen, Paniz Kamran, Peng Zhao, Sara Ranjbarvaziri, Shuin Park, Shan Sabri, James L. Engel, Kevin Sung, Rajan P. Kulkarni, Yichen Ding, Tzung K. Hsiai, Kathrin Plath, Jason Ernst, Debashis Sahoo, Hanna K.A. Mikkola, M. Luisa Iruela-Arispe, Reza Ardehali
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
During cardiac tissue formation it is unclear whether newly generated myocytes originate from cardiac progenitor cells or from pre-existing cardiomyocytes. Here, the authors use a stochastic four-colour reporter system (Rainbow) to identify the sourc
Externí odkaz:
https://doaj.org/article/c802b51efbb94834a80f05d3baafd799
Autor:
Kathleen M. Ruppel, John Perrino, Daniel Bernstein, Kristina B. Kooiker, Tiffany T. Koyano, Rahel A. Woldeyes, Joseph C. Wu, Joseph Woo, Kévin Contrepois, Robyn Fong, Mingming Zhao, Alison Schroer Vander Roest, James A. Spudich, Ning Ma, Sara Ranjbarvaziri, Michael Snyder, Sushma Reddy, Wah Chiu, Mathew Ellenberger, Lei Tian, Frandics P. Chan, Gavin M. Traber, Giovanni Fajardo
Publikováno v:
Circulation, vol 144, iss 21
Circulation
Circulation
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to
Autor:
Jin Yang, Francis Grafton, Sara Ranjbarvaziri, Ana Budan, Farshad Farshidfar, Marie Cho, Emma Xu, Jaclyn Ho, Mahnaz Maddah, Kevin E. Loewke, Julio Medina, David Sperandio, Snahel Patel, Tim Hoey, Mohammad A. Mandegar
Publikováno v:
Science translational medicine. 14(652)
Dilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying
Autor:
Hyun Tae V. Hwang, Daniel Bernstein, Dong-Qing Hu, Kristina B. Kooiker, Nefthi Sandeep, Michael Coronado, Mingming Zhao, Sushma Reddy, Giovanni Fajardo, Sharon L. Paige, Sara Ranjbarvaziri, Sean M. Wu, Ingrid S. Lan
Publikováno v:
Circulation
Background: In patients with complex congenital heart disease, such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload stress, leading to RV hypertrophy and eventually RV failure. The role of lipid peroxidatio
Autor:
Yifei Miao, Soah Lee, Sharon L. Paige, M. Yasir Qureshi, Sidra Xu, Julia Ryan, Sean M. Wu, Daniel Bernstein, Mingxia Gu, Timothy J. Nelson, Dries A.M. Feyen, Marlene Rabinovitch, Sara Ranjbarvaziri, Euan A. Ashley, Mark Mercola, Adrija K. Darsha, Elizabeth T Chin, Aimee Beck, Victoria N. Parikh, Francisco X Galdos
Publikováno v:
Circulation
Publikováno v:
JACC: Basic to Translational Science. 5:432-443
Highlights •After in vitro stimulation or in vivo pressure overload injury, activated cardiac fibroblasts express Ltbp2, Comp, and Cilp. •In ischemic heart disease, LTBP2, COMP, and CILP localize to the fibrotic regions of the injured heart. •C
Autor:
Kristina Green, Farshad Farshidfar, Sara Ranjbarvaziri, Patel Snahel, Jaclyn J. Ho, Mahnaz Maddah, Mohammad A. Mandegar, Tim Hoey, Stephanie Steltzer, Francis Grafton, Anastasiia Budan, Kevin E. Loewke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a288d2a8add948bff2c2e180b7a97cfd
https://doi.org/10.7554/elife.68714.sa2
https://doi.org/10.7554/elife.68714.sa2
Autor:
Makenna M. Morck, Daniel Bernstein, Sara Ranjbarvaziri, Gwanghyun Jung, Kristina B. Kooiker, Alison Schroer Vander Roest, Kathleen M. Ruppel, Aminah Dawood, James A. Spudich, Arnav Jhingran, Beth L. Pruitt, Kenneth S. Campbell, Gaspard Pardon, Chao Liu, Dan Song, Mingming Zhao, Giovanni Fajardo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Heart disease is the leading cause of death worldwide, and hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, affecting over 1 in 200 people. Mutations in myosin, the motor protein responsible for contr