Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sara R.A. Wijnant"'
Autor:
Elizabeth Benz, Sara R.A. Wijnant, Katerina Trajanoska, Johnmary T. Arinze, Emmely W. de Roos, Maria de Ridder, Ross Williams, Frank van Rooij, Katia M.C. Verhamme, M. Arfan Ikram, Bruno H. Stricker, Fernando Rivadeneira, Lies Lahousse, Guy G. Brusselle
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
Background Increasing evidence suggests that sarcopenia and a higher systemic immune-inflammation index (SII) are linked with morbidity in patients with COPD. However, whether these two conditions contribute to all-cause mortality in middle-aged and
Externí odkaz:
https://doaj.org/article/0b9a80b5eddb45909c525576b82c5525
Autor:
Merel Jacobs, Lies Lahousse, Hannelore P. Van Eeckhoutte, Sara R.A. Wijnant, Joris R. Delanghe, Guy G. Brusselle, Ken R. Bracke
Publikováno v:
ERJ Open Research, Vol 7, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/a799e1c8b0e843d3b06106c0c9c2635a
Autor:
Ida Mogensen, Judith M. Vonk, Sara R.A. Wijnant, Xingwu Zhou, H. Marike Boezen, Guy Brusselle, Lies Lahousse, Christer Janson, Andrei Malinovschi
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Background Elevated blood eosinophils have been associated with lower lung function and are believed to be associated with accelerated lung function decline. Method Blood eosinophils were measured in four cohorts:
Externí odkaz:
https://doaj.org/article/2e561a5fefff4f37a1d8f35c8550e0d1
Autor:
Lowie E.G.W. Vanfleteren, Arnulf Langhammer, Shoaib Afzal, Peter Lange, Børge G. Nordestgaard, Helena Backman, Sylvia Hartl, Maarten van den Berge, Eva Rönmark, Marie-Kathrin Breyer, Otto C. Burghuber, Alvar Agusti, Guy Brusselle, Rosa Faner, Bo Lundbäck, Sigrid A Aalberg Vikjord, Jørgen Vestbo, Jadwiga A. Wedzicha, Judith M. Vonk, Robab Breyer-Kohansal, James P. Allinson, Sara R.A. Wijnant, H. Marike Boezen, Gavin C. Donaldson, Nuria Olvera, Bright I Nwaru, Yunus Çolak, Deborah Jarvis, Lies Lahousse
Publikováno v:
The Lancet. Respiratory Medicine, 10(1), 83-94. ELSEVIER SCI LTD
The Lancet Respiratory Medicine
The Lancet Respiratory Medicine, 10(1), 83-94. Elsevier Ltd.
The Lancet Respiratory Medicine
The Lancet Respiratory Medicine, 10(1), 83-94. Elsevier Ltd.
Background: During the past century, socioeconomic and scientific advances have resulted in changes in the health and physique of European populations. Accompanying improvements in lung function, if unrecognised, could result in the misclassification
Autor:
Natalie Terzikhan, Guy Brusselle, M. Arfan Ikram, Lies Lahousse, Silvan Licher, M. Kamran Ikram, Tian Xiao, Sara R.A. Wijnant
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, 82(2), 621-630. IOS Press BV
JOURNAL OF ALZHEIMERS DISEASE
Journal of Alzheimer's Disease, 82(2), 621-630. IOS Press BV
JOURNAL OF ALZHEIMERS DISEASE
Background: The etiology of dementia may partly be underpinned by impaired lung function via systemic inflammation and hypoxia. Objective: To prospectively examine the association between chronic obstructive pulmonary disease (COPD) and subclinical i
Autor:
Sara R.A. Wijnant, Bruno Lapauw, Guy Brusselle, Guy Joos, Ken R. Bracke, Hannelore Van Eeckhoutte, Merel Jacobs
Publikováno v:
Diabetes, 69(12), 2691-2699. American Diabetes Association Inc.
DIABETES
DIABETES
Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to increased infectivity of COVID-19 in patients with diabetes, but ACE2 expression has not been studied in lung tissue of subjects with diabetes. We therefore studied
Autor:
Alison D. Murray, Anna L. Guyatt, Jing Hua Zhao, Eugene R. Bleecker, Matthias Wielscher, Frank Dudbridge, Martin D. Tobin, Veronique Vitart, Ida Surakka, Nadia N. Hansel, Ozren Polasek, Caroline Hayward, David P. Strachan, Per Bakke, Stefan Karrasch, Anubha Mahajan, James F. Wilson, Shona M. Kerr, Ruth Tal-Singer, James D. Crapo, Victoria E. Jackson, Jonathan Marten, Olli T. Raitakari, María Soler Artigas, Medea Imboden, Sungho Won, Beate Stubbe, Ulf Gyllensten, George R. Washko, Eleftheria Zeggini, David A. Lynch, Brian D. Hobbs, Matthew Moll, Mika Kähönen, Rajesh Rawal, Guy Brusselle, Ma'en Obeidat, Nicholas J. Wareham, Claudia Langenberg, Nicole Probst-Hensch, Peter K. Joshi, Blair H. Smith, Stefan Weiss, Woo Jin Kim, Kathleen C. Barnes, Sarah E. Harris, David J. Porteous, Stefan Enroth, Ian P. Hall, Alan L. James, Sina A. Gharib, Paul R. H. J. Timmers, Xingnan Li, Louise V. Wain, John E. Hokanson, Holger Schulz, Ralf Ewert, Ani Manichaikul, Lies Lahousse, Georg Homuth, R. Graham Barr, Scott T. Weiss, Phuwanat Sakornsakolpat, Sara R.A. Wijnant, Edwin K. Silverman, Christian Gieger, Jennie Hui, Andrew P. Morris, James P. Cook, Michael J. McGeachie, Dawn L. DeMeo, Nick Shrine, Traci M. Bartz, Amund Gulsvik, Deborah A. Meyers, Katherine A. Kentistou, Igor Rudan, Jian'an Luan, Ian J. Deary, Catherine John, Michael H. Cho, Lars Lind, Marjo-Riitta Järvelin, Ah Ra Do, Terho Lehtimäki, Stephen S. Rich, Bruce M. Psaty
Publikováno v:
The Lancet. Respiratory Medicine
Moll, M, Sakornsakolpat, P, Shrine, N, Hobbs, B D, DeMeo, D L, John, C, Guyatt, A L, McGeachie, M J, Gharib, S A, Obeidat, M, Lahousse, L, Wijnant, S R A, Brusselle, G, Meyers, D A, Bleecker, E R, Li, X, Tal-Singer, R, Manichaikul, A, Rich, S S, Won, S, Kim, W J, Do, A R, Washko, G R, Barr, R G, Psaty, B M, Bartz, T M, Hansel, N N, Barnes, K, Hokanson, J E, Crapo, J D, Lynch, D, Bakke, P, Gulsvik, A, Hall, I P, Wain, L, Soler Artigas, M, Jackson, V E, Strachan, D P, Hui, J, James, A L, Kerr, S M, Polasek, O, Vitart, V, Marten, J, Rudan, I, Kähönen, M, Surakka, I, Gieger, C, Karrasch, S, Rawal, R, Schulz, H, Deary, I J, Harris, S E, Enroth, S, Gyllensten, U, Imboden, M, Probst-Hensch, N M, Lehtimäki, T, Raitakari, O T, Langenberg, C, Luan, J, Wareham, N, Zhao, J H, Hayward, C, Murray, A, Porteous, D J, Smith, B H, Jarvelin, M R, Wielscher, M, Joshi, P K, Kentistou, K A, Timmers, P RHJ, Wilson, J F, Cook, J P, Lind, L, Mahajan, A, Morris, A P, Ewert, R, Homuth, G, Stubbe, B, Weiss, S, Zeggini, E, Weiss, S T, Silverman, E K, Dudbridge, F, Tobin, M D & Cho, M H 2020, ' Chronic obstructive pulmonary disease and related phenotypes : polygenic risk scores in population-based and case-control cohorts ', The Lancet Respiratory Medicine, vol. 8, no. 7, pp. 696-708 . https://doi.org/10.1016/S2213-2600(20)30101-6
LANCET RESPIRATORY MEDICINE
Lancet Resp. Med. 8, 696-708 (2020)
The Lancet Respiratory Medicine, 8(7), 696-708. Elsevier Ltd.
Moll, M, Sakornsakolpat, P, Shrine, N, Hobbs, B D, DeMeo, D L, John, C, Guyatt, A L, McGeachie, M J, Gharib, S A, Obeidat, M, Lahousse, L, Wijnant, S R A, Brusselle, G, Meyers, D A, Bleecker, E R, Li, X, Tal-Singer, R, Manichaikul, A, Rich, S S, Won, S, Kim, W J, Do, A R, Washko, G R, Barr, R G, Psaty, B M, Bartz, T M, Hansel, N N, Barnes, K, Hokanson, J E, Crapo, J D, Lynch, D, Bakke, P, Gulsvik, A, Hall, I P, Wain, L, Soler Artigas, M, Jackson, V E, Strachan, D P, Hui, J, James, A L, Kerr, S M, Polasek, O, Vitart, V, Marten, J, Rudan, I, Kähönen, M, Surakka, I, Gieger, C, Karrasch, S, Rawal, R, Schulz, H, Deary, I J, Harris, S E, Enroth, S, Gyllensten, U, Imboden, M, Probst-Hensch, N M, Lehtimäki, T, Raitakari, O T, Langenberg, C, Luan, J, Wareham, N, Zhao, J H, Hayward, C, Murray, A, Porteous, D J, Smith, B H, Jarvelin, M R, Wielscher, M, Joshi, P K, Kentistou, K A, Timmers, P RHJ, Wilson, J F, Cook, J P, Lind, L, Mahajan, A, Morris, A P, Ewert, R, Homuth, G, Stubbe, B, Weiss, S, Zeggini, E, Weiss, S T, Silverman, E K, Dudbridge, F, Tobin, M D & Cho, M H 2020, ' Chronic obstructive pulmonary disease and related phenotypes : polygenic risk scores in population-based and case-control cohorts ', The Lancet Respiratory Medicine, vol. 8, no. 7, pp. 696-708 . https://doi.org/10.1016/S2213-2600(20)30101-6
LANCET RESPIRATORY MEDICINE
Lancet Resp. Med. 8, 696-708 (2020)
The Lancet Respiratory Medicine, 8(7), 696-708. Elsevier Ltd.
Background: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COP
Autor:
Mar Rodríguez-Girondo, Inge M. M. Lakeman, André G. Uitterlinden, Andy C. H. Lee, Peter Devilee, Bruno H. Stricker, Antonis C. Antoniou, Jeroen van Rooij, Sara R.A. Wijnant, Marjanka K. Schmidt, Rikje Ruiter, Maryam Kavousi
Publikováno v:
Genetics in Medicine, 22(11), 1803-1811. NATURE PUBLISHING GROUP
Genetics in Medicine, 22(11), 1803-1811. Lippincott Williams & Wilkins
Genetics in Medicine
Genetics in Medicine, 22(11), 1803-1811. Lippincott Williams & Wilkins
Genetics in Medicine
Purpose We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score (PRS) based on 313 breast
Autor:
Guy Brusselle, Bruno H. Stricker, Maryam Kavousi, Daniel Bos, Aad van der Lugt, Meike W. Vernooij, Lies Lahousse, Sara R.A. Wijnant
Publikováno v:
ATHEROSCLEROSIS
Atherosclerosis, 291, 107-113. Elsevier Ireland Ltd
Atherosclerosis, 291, 107-113. Elsevier Ireland Ltd
Background and aims: COPD is associated with an increased risk of cardiovascular morbidity and mortality, potentially by mechanisms of atherosclerosis. Insight into location-specific vulnerability to atherosclerosis in COPD, including intracranial ar
Autor:
Andrew G. Jarnicki, Guy Brusselle, Philip M. Hansbro, Paul S. Foster, Peter A. B. Wark, Griet Conickx, Gaetano Caramori, Pieter Mestdagh, Fabio Lm Ricciardolo, Alan Hsu, Gang Liu, Krishna P. Sunkara, Emma L. Beckett, Sara R.A. Wijnant, Jay C. Horvat, Antonio Ieni, Izabela Galvão, Chantal Donovan, Richard Kim, Tatt Jhong Haw, Angela Ferguson, Antonino Di Stefano, Umamainthan Palendira, Ken R. Bracke
Publikováno v:
Science Translational Medicine. 13
Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed countries. Current therapies have limited efficacy in controlling disease or