Výsledky vyhledávání - "Sara R. Tanqueiro"

Akademický článek

High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats

Autor: Sara L. Paulo, Catarina Miranda-Lourenço, Rita F. Belo, Rui S. Rodrigues, João Fonseca-Gomes, Sara R. Tanqueiro, Vera Geraldes, Isabel Rocha, Ana M. Sebastião, Sara Xapelli, Maria J. Diógenes

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 2305-2319 (2021)

The increasing consumption of sugar and fat seen over the last decades and the consequent overweight and obesity, were recently linked with a deleterious effect on cognition and synaptic function. A major question, which remains to be clarified, is w

Externí odkaz: https://doaj.org/article/c7b70d863682401eac2ab9dee32953d3

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Akademický článek

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Publikováno v: Neurobiology of Disease, Vol 163, Iss , Pp 105603- (2022)

Alzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Prev

Externí odkaz: https://doaj.org/article/64ca49ebf34d4f8fba3b77430bcc78cd

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Akademický článek

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

Autor: Sara R. Tanqueiro, Rita M. Ramalho, Tiago M. Rodrigues, Luísa V. Lopes, Ana M. Sebastião, Maria J. Diógenes

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Brain-derived neurotrophic factor (BDNF) plays important functions in cell survival and differentiation, neuronal outgrowth and plasticity. In Alzheimer’s disease (AD), BDNF signaling is known to be impaired, partially because amyloid β (Aβ) indu

Externí odkaz: https://doaj.org/article/9825c12b389b45e5bdf16705ffc339de

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In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

Autor: Pedro Ruivo, Sara R. Tanqueiro, Francisco M. Mouro, João Fonseca-Gomes, Maria do Carmo Pereira, Ana M. Sebastião, Tânia Carvalho, Maria José Diógenes, Joana A. Loureiro

Publikováno v: International Journal of Nanomedicine. 15:8609-8621

Introduction Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::344fb7a70d4a58cd0d8fc8aebb73cace
https://doi.org/10.2147/ijn.s267007

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Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders

Autor: Sara L Paulo, João B Moreira, Ana M. Sebastião, Sara R. Tanqueiro, Sara Xapelli, Rui S Rodrigues, Maria José Diógenes

Publikováno v: Stem Cells and Development. 29:1099-1117

The development of new therapies for psychiatric disorders is of utmost importance, given the enormous toll these disorders pose to society nowadays. This should be based on the identification of neural substrates and mechanisms that underlie disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641f0d41e7ce3d6d2825b9d2cf7efa99
https://doi.org/10.1089/scd.2020.0100

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Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice

Autor: João Fonseca-Gomes, Ana M. Sebastião, Neil Dawson, Frederico Simões do Couto, C. Ferreira, Maria José Diógenes, Sara R. Tanqueiro, Francisco M. Mouro, Céline Felicidade Freitas

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Copyright © 2021, © SAGE Publications
Background: Cognitive deficits profoundly impact on the quality of life of patients with schizophrenia. Alterations in brain derived neurotrophic factor (BDNF) signalling, which regulates synaptic function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aed2622f471bacaac2ed58471886a78
https://doi.org/10.1177/02698811211008560

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Challenges of BDNF-based therapies: From common to rare diseases

Autor: Tiago Costa-Coelho, Sara R. Tanqueiro, Sara Xapelli, Leonor Ribeiro-Rodrigues, Rita F. Belo, Céline Felicidade Freitas, Mafalda Ferreira-Manso, João Fonseca-Gomes, C. Ferreira, Nádia Rei, Tiago Rodrigues, Ana M. Sebastião, Svitlana Zavalko, Carolina de Almeida-Borlido, Catarina Miranda-Lourenço, Maria José Diógenes, Francisco M. Mouro

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© 2020 Elsevier Ltd. All rights reserved.
Neurotrophins are a well-known family of neurotrophic factors that play an important role both in the central and peripheral nervous systems, where they modulate neuronal survival, development, function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94856968b12fc6d66adfabd8b1431826
https://doi.org/10.1016/j.phrs.2020.105281

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