Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sara R. Hamilton"'
Autor:
Kelly Tai, Mitchell G. Vainberg, Tak W. Mak, Han You, Josef M. Penninger, Michael E. Parsons, James R. Woodgett, Amy E. Lin, Sara R. Hamilton, Kristine M. Garza, Karl S. Lang, Alisha R. Elford, Kip Wigmore, Charles W. Tran, Thierry Le Bihan, Samuel D. Saibil, Pamela S. Ohashi
Publikováno v:
The Journal of Immunology. 199:4056-4065
The decision between T cell activation and tolerance is governed by the spatial and temporal integration of diverse molecular signals and events occurring downstream of TCR and costimulatory or coinhibitory receptor engagement. The PI3K–protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba0b8e31e661bcc16210805dd5e742a
https://doi.org/10.4049/jimmunol.1600396
https://doi.org/10.4049/jimmunol.1600396
Autor:
Tak W. Mak, Zhenyue Hao, Sara R. Hamilton, Juan Carlos Zúñiga-Pflücker, Jillian Haight, Satoshi Inoue, Wanda Y. Li, Gloria H. Y. Lin, Gordon S. Duncan, Yi Sheng, Dirk Brenner, Alisha R. Elford, Yi Liang, Yu-Wen Su, Jennifer Sylvester, Annick You-Ten, Pamela S. Ohashi, Housheng Hansen He, Andrew Wakeham, Bryan E. Snow, Carmen Dominguez
Publikováno v:
Hao, Z, Sheng, Y, Duncan, G S, Li, W Y, Dominguez, C, Sylvester, J, Su, Y W, Lin, G H Y, Snow, B E, Brenner, D, You-Ten, A, Haight, J, Inoue, S, Wakeham, A, Elford, A, Hamilton, S, Liang, Y, Zúñiga-Pflücker, J C, He, H H, Ohashi, P S & Mak, T W 2017, ' K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression ', Nature Communications, vol. 8, 14003 . https://doi.org/10.1038/ncomms14003
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
T-cell proliferation is regulated by ubiquitination but the underlying molecular mechanism remains obscure. Here we report that Lys-48-linked ubiquitination of the transcription factor KLF4 mediated by the E3 ligase Mule promotes T-cell entry into S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb6ad37e27a36cbb1f5ecc9d267e167
https://doi.org/10.1038/ncomms14003
https://doi.org/10.1038/ncomms14003
Autor:
Haifeng C. Xu, Alisha R. Elford, Philipp A. Lang, Dieter Häussinger, Michael Lohoff, David R. McIlwain, Aleksandra A. Pandyra, Tak W. Mak, D E Speiser, Stefanie Scheu, Sathish Kumar Maney, Melanie Grusdat, Magdalena Huber, Karl S. Lang, Elisabeth Lang, Vitaly I. Pozdeev, Sarah Q. Crome, Celine Robert-Tissot, Regine J. Dress, H-W Mittrücker, J Knievel, Pamela S. Ohashi, Johannes G. Bode, Sara R. Hamilton, Klaus Pfeffer
Publikováno v:
CELL DEATH AND DIFFERENTIATION
Cell Death and Differentiation, vol. 21, no. 7, pp. 1050-1060
Cell death and differentiation
Cell Death and Differentiation
Cell Death and Differentiation, vol. 21, no. 7, pp. 1050-1060
Cell death and differentiation
Cell Death and Differentiation
CD8(+) T cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses beneficial destruction of infected cells must be balanced against immunopathology resulting from collateral damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2560a5c5c316b9a1e2c3e304726e9899
Autor:
Håkan Hall, Nancy Berg-Brown, Sara R. Hamilton, Jennifer L. Gommerman, Leslie Summers deLuca, Pamela S. Ohashi, Kiichi Murakami, Alisha R. Elford, Dilan Dissanayake
Publikováno v:
Nature Medicine. 17:1663-1667
Mature dendritic cells (DCs) are crucial for the induction of adaptive immune responses and perturbed DC homeostasis can result in autoimmune disease. Either uncontrolled expansion or enhanced survival of DCs can result in a variety of autoimmune dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8073e6c8f3281aef4be746af90b05d40
https://doi.org/10.1038/nm.2556
https://doi.org/10.1038/nm.2556
Autor:
Kenneth Virgel N. Esguerra, Lyndsey Morningstar, Jing Zhang, Patrick G. Telmer, James B. McCarthy, S. Zhang, Cornelia Tolg, Rene E. Harrison, Len G. Luyt, Sara R. Hamilton, Eva A. Turley
Publikováno v:
Chemistry Publications
An oncogenic form of RHAMM (receptor for hyaluronan-mediated motility, mouse, amino acids 163-794 termed RHAMM(Delta163)) is a cell surface hyaluronan receptor and mitotic spindle protein that is highly expressed in aggressive human cancers. Its regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b878a378d8d2deed6c27084f087d69aa
https://doi.org/10.1074/jbc.m110.121491
https://doi.org/10.1074/jbc.m110.121491
Autor:
James Koropatnick, Eva A. Turley, Françoise M. Winnik, Mario Gonzalez, Rommel G. Tirona, David J. Freeman, Samuel Asculai, Cornelia Tolg, Mandana Veiseh, Michael Vanzieleghem, Richard Brown, Jakob Richardson, Sara R. Hamilton, Patricia Anderson, Rashmin C. Savani, Leonard G. Luyt
Publikováno v:
The Open Drug Metabolism Journal. 3:43-55
The pharmacodynamics and elimination kinetics of escalating doses (1.5-12 mg/kg) of hyaluronan (HA) infu- sions were studied in healthy human volunteers. Metabolic breakdown of serum HA and associated adverse events were monitored throughout the stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3ffe51e982c3001b6e9871dbf1e5328
https://doi.org/10.2174/1874073100903010043
https://doi.org/10.2174/1874073100903010043
Autor:
Mina J. Bissell, James B. McCarthy, Sean J. Leith, Sallie Elhayek, S. Bahram Bahrami, Eva A. Turley, Sara R. Hamilton, Mandana Veiseh, Lisa Collis, Cornelia Tolg
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 3 (2015)
Frontiers in Cell and Developmental Biology, Vol 3 (2015)
The interaction of hyaluronan (HA) with mesenchymal progenitor cells impacts trafficking and fate after tissue colonization during wound repair and these events contribute to diseases such as cancer. How this interaction occurs is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab1261661c68d7b9d798152dc49720a
https://doi.org/10.3389/fcell.2015.00063
https://doi.org/10.3389/fcell.2015.00063
Autor:
Nancy Agmon-Levin, S. Sohail Ahmed, Youssif M. Ali, Martin Aringer, Jean-François Bach, Jennifer Barker, Robert N. Barker, Alan G. Baxter, Corrado Betterle, Stanca A. Birlea, Niklas K. Björkström, Paul A. Blair, Alex Bobik, Nabeel H. Borazan, Xavier Bosch, Robert A. Brodsky, Yenan T. Bryceson, Patrick R. Burkett, James B. Bussel, Helmut Butzkueven, Roberto Caricchio, Livia Casciola-Rosen, Patrizio Caturegli, Lucienne Chatenoud, Philip L. Cohen, Ken Coppieters, Sarah Q. Crome, Ronald G. Crystal, Donna A. Culton, Monica D. Dalal, Chella S. David, Anne Davidson, Ahmed J. Delli, Peter J. Delves, Vera Kandror Denmark, Betty Diamond, Luis A. Diaz, John E. Eaton, George S. Eisenbarth, Ronald J. Falk, Judith Field, Thomas A. Fleisher, George E. Fragoulis, Marvin J. Fritzler, Daniel E. Furst, Stefania Gallucci, Brian Gelbman, M. Eric Gershwin, Daniel R. Getts, Meghann Teague Getts, Roberto Gianani, Paul A. Gleeson, James W. Goding, Siamon Gordon, Jörg J. Goronzy, Judith M. Greer, Berengere Gruson, L. Guilherme, Angelika Gutenberg, David A. Hafler, Bevra H. Hahn, Hideaki Hamano, Sara R. Hamilton, Leonard C. Harrison, Amanda L. Hernandez, Eystein Husebye, J. Charles Jennette, Richard J. Jones, Margaret A. Jordan, J. Kalil, Christoph Königs, Shigeyuki Kawa, Ziya Kaya, Jennifer K. King, Nicholas J.C. King, Kendo Kiyosawa, Mitchell Kronenberg, Vijay K. Kuchroo, Tin Kyaw, Jan Lünemann, Robert G. Lahita, Parviz Lalezari, Paul-Henri Lambert, Eric Lancaster, Arian Laurence, Youjin Lee, Michael Lenardo, Åke Lernmark, Arnold I. Levinson, Keith D. Lindor, Zhi Liu, Hans-Gustaf Ljunggren, Claudio Lunardi, Knut E.A. Lundin, Michael P.T. Lunn, Isabella Lupi, Livia Lustig, Christian Münz, Charles R. Mackay, Ian R. Mackay, Clara Malattia, Ashutosh Mangalam, Alberto Martini, Claudia Mauri, Clio P. Mavragani, Lloyd Mayer, Pamela A. McCombe, Fritz Melchers, Giorgina Mieli-Vergani, Frederick W. Miller, Stephen D. Miller, Masayuki Mizui, Jenny Mjösberg, Haralampos M. Moutsopoulos, David A. Norris, Robert B. Nussenblatt, Kevin C. O’Connor, Pamela S. Ohashi, Meredith O’Keeffe, Joao Bosco Oliveira, Joost J. Oppenheim, Alicia Perez-Arroyo, Anneli Peters, Pärt Peterson, Annette Plüddemann, Jerome B. Posner, Gloria A. Preston, Antonio Puccetti, Kristen Radford, Manuel Ramos-Casals, V. Koneti Rao, Paula K. Rauschkolb, Venkat Reddy, Kurt Redlich, Claudia Rival, Noel R. Rose, Antony Rosen, John W. Schrader, Wilhelm J. Schwaeble, Carlo Selmi, H. Nida Sen, Marc Serota, Kazim A. Sheikh, Yehuda Shoenfeld, Ken Shortman, Joachim Sieper, Arthur M. Silverstein, Robert B. Sim, Anna Simon, Josef S. Smolen, Ludvig M. Sollid, Monique Stoffels, Helen Su, Uta Syrbe, Jayant A. Talwalkar, Veena Taneja, Angela Tincani, Peter Tipping, Ban-Hock Toh, George C. Tsokos, Eric Tu, Kenneth S.K. Tung, Ian R. van Driel, Diego Vergani, Mark A. Vickers, Stuart Viegas, Angela Vincent, Ulrich H. von Andrian, Matthias von Herrath, Anthony P. Weetman, John M. Wentworth, Cornelia M. Weyand, Gerhard Wingender, Renato Zanchetta, Moncef Zouali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064479aded1363869b81d19d78b1f968
https://doi.org/10.1016/b978-0-12-384929-8.00090-3
https://doi.org/10.1016/b978-0-12-384929-8.00090-3
Autor:
Sara R. Hamilton, Michael St. Paul, Bryan E. Snow, Colin Reardon, Anne Brüstle, Aline Pfefferle, Gloria H. Y. Lin, Tak W. Mak, Michael W. Tusche, Christiane B. Knobbe-Thomsen, Gordon S. Duncan, Karl S. Lang, Pamela S. Ohashi, Philipp A. Lang, Dirk Brenner, Syed O. Gilani
The ability to mount a strong immune response against pathogens is crucial for mammalian survival. However, excessive and uncontrolled immune reactions can lead to autoimmunity. Unraveling how the reactive versus tolerogenic state is controlled might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e83ff06a9dfc0764ace1c4dcefb8068
https://www.ncbi.nlm.nih.gov/pubmed/24398517
https://www.ncbi.nlm.nih.gov/pubmed/24398517
The development of a healthy adaptive immune system requires a T cell repertoire diverse enough to recognize foreign antigen while limiting recognition of self-antigens to avoid autoimmunity. However, this idea gives rise to many questions. If all ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24cc330211c301edfcc48ce6fee4528b
https://doi.org/10.1016/b978-0-12-384929-8.00007-1
https://doi.org/10.1016/b978-0-12-384929-8.00007-1