ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer

Autor: Gianluca Mucciolo, Joaquín Araos Henríquez, Sara Pinto Teles, Judhell S. Manansala, Muntadher Jihad, Wenlong Li, Eloise G. Lloyd, Priscilla S.W. Cheng, Giulia Biffi

SUMMARYPancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Cancer-associated fibroblasts (CAFs) are recognized potential therapeutic targets, but poor understanding of these heterogeneous cell populations has limited the development of ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27fa87835ecb4125328aacf4c20ad1f1
https://doi.org/10.1101/2022.12.05.519080

Abstract C039: An EGFR-activated subset of myofibroblastic cancer-associated fibroblasts supports local metastatic dissemination in pancreatic ductal adenocarcinoma

Autor: Gianluca Mucciolo, Joaquín Araos Henríquez, Sara Pinto Teles, Judhell Manansala, Wenlong Li, Eloise G. Lloyd, Priscilla Cheng, Giulia Biffi

Publikováno v: Cancer Research. 82:C039-C039

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and new therapies are needed. Cancer-associated fibroblasts (CAFs) can promote PDA progression and are recognized promising therapeutic targets. However, the ongoing characterization of PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::131e2351c629182c46b52cb4d09f9503
https://doi.org/10.1158/1538-7445.panca22-c039

Abstract PR016: Aging modulates the tumor microenvironment of pancreatic cancer

Autor: Joaquín Araos Henríquez, Judhell Manansala, Sara Pinto Teles, Muntadher Jihad, Eloise G. Lloyd, Amir Jassim, Richard J. Gilbertson, Giulia Biffi

Publikováno v: Cancer Research. 82:PR016-PR016

Pancreatic ductal adenocarcinoma (PDAC) has a very poor clinical outcome due to late diagnosis and resistance to therapies. Its epithelial compartment is surrounded by a cancer-associated fibroblast (CAF)-rich stroma that has been shown to be highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94dbe716b1683ff7b223e7c32cfc02ab
https://doi.org/10.1158/1538-7445.panca22-pr016

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development

Autor: Joaquín J Maqueda, Sara Pinto Teles, Irene Gullo, Maria M. Azevedo, Carla Oliveira, Marieke E. Ijsselsteijn, Marta I. Oliveira, Joana Carvalho, Afonso P Basto, Gabriela M. Almeida, Noel F C C de Miranda, Luis Graca, João T. Barata, Sara Rocha, Gilza Gonçalves, Fátima Carneiro

Publikováno v: Cancers
Cancers, 13(3). MDPI
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cancers, Vol 13, Iss 421, p 421 (2021)
Volume 13
Issue 3

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b1aaa01d75a4892a36852cb038eb5f

Gastric Cancer Extracellular Vesicles Tune the Migration and Invasion of Epithelial and Mesenchymal Cells in a Histotype-Dependent Manner

Autor: Joana Carvalho, Sara Pinto Teles, Carla Oliveira, Patrícia Oliveira, Mafalda Azevedo, Sara Rocha

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 11, p 2608 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 11

Extracellular vesicles (EVs) secreted by tumor cells modulate recipient cells&rsquo
behavior, but their effects in normal cells from the tumor microenvironment remain poorly known. In this study, we dissected the functional impact of gastric can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0217515a50b63b03bf7a49c0de7b6017
https://www.mdpi.com/1422-0067/20/11/2608