Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking

Autor: Pedro Sampaio, Sara Pestana, Catarina Bota, Adán Guerrero, Ivo A Telley, David Smith, Susana Santos Lopes

Publikováno v: eLife, Vol 12 (2023)

Humans and other vertebrates define body axis left-right asymmetry in the early stages of embryo development. The mechanism behind left-right establishment is not fully understood. Symmetry breaking occurs in a dedicated organ called the left-right o

Externí odkaz: https://doaj.org/article/e14f5cee78fe4b7092a92a30f8034192

Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia

Autor: Andreia L. Pinto, Margarida Rasteiro, Catarina Bota, Sara Pestana, Pedro Sampaio, Claire Hogg, Thomas Burgoyne, Susana S. Lopes

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 16, p 8361 (2021)

Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many cili

Externí odkaz: https://doaj.org/article/2216c5080482403cba47ae664b51ca19

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Autor: Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes

Publikováno v: eLife, Vol 6 (2017)

Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia d

Externí odkaz: https://doaj.org/article/95a4f2296f454450a280a158e5ad75f2

Zebrafish model as a screen to prevent cyst inflation in autosomal dominant polycystic kidney disease

Autor: Raquel Jacinto, Fernando Nolasco, Sara Pestana, Joaquim Calado, Inês Filipa Fernandes de Oliveira, Susana S. Lopes, Mónica Roxo-Rosa

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
International Journal of Molecular Sciences, Vol 22, Iss 9013, p 9013 (2021)

Funding Information: Funding: This work was supported by Sociedade Portuguesa de Nefrologia, iNOVA4Health-UID/Multi/04462/2013 (a program financially supported by Fundação para a Ciência e Tecnolo-gia (FCT)/Ministério da Educação e Ciência, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ec02fe49f513c6aeb5d98ff49bc97e
https://hdl.handle.net/10362/125091

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Autor: Pedro Sampaio, Britta Schilling, Sara Pestana, Ian Henry, Telma Lopes, Rui Gardner, Andreia Vaz, Susana S. Lopes, Mónica Roxo-Rosa, Leonor Saúde, Raquel Jacinto, Bárbara Tavares, Andreia Pinto

Publikováno v: eLife
eLife, Vol 6 (2017)

© 2017, Tavares et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Foxj1a is necessary and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332488879f802c2d63b3339090e209a8
https://doi.org/10.7554/elife.25165