Quantification of T-cell dynamics during latent cytomegalovirus infection in humans.

Autor: Sara P H van den Berg, Lyanne Y Derksen, Julia Drylewicz, Nening M Nanlohy, Lisa Beckers, Josien Lanfermeijer, Stephanie N Gessel, Martijn Vos, Sigrid A Otto, Rob J de Boer, Kiki Tesselaar, José A M Borghans, Debbie van Baarle

Publikováno v: PLoS Pathogens, Vol 17, Iss 12, p e1010152 (2021)

Cytomegalovirus (CMV) infection has a major impact on the T-cell pool, which is thought to be associated with ageing of the immune system. The effect on the T-cell pool has been interpreted as an effect of CMV on non-CMV specific T-cells. However, it

Externí odkaz: https://doaj.org/article/75fa94e444bf43b9ac20d94ea3bccc0d

Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults

Autor: Sara P. H. van den Berg, Albert Wong, Marion Hendriks, Ronald H. J. Jacobi, Debbie van Baarle, Josine van Beek

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Older adults are more vulnerable to influenza virus infection and at higher risk for severe complications and influenza-related death compared to younger adults. Unfortunately, influenza vaccine responses tend to be impaired in older adults due to ag

Externí odkaz: https://doaj.org/article/86b7c58552fa44089f2046676052a2d5

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner

Autor: Martin Potts, Bernadet Blijenberg, Thomas Stamminger, Adriana Svrlanska, Niels Bovenschen, Astrid Hendriks, Ian J. Groves, Liling Shan, Sara P. H. van den Berg, Jan Meeldijk, Karlijn J. W. M. van Boxtel, Shuang Li, Mark R. Wills

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008426 (2020)

Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d435840b4eae7def284bb4353e27925

The hallmarks of CMV-specific CD8 T-cell differentiation

Autor: Debbie van Baarle, Iris N. Pardieck, Ramon Arens, Delphine Sauce, Paul Klenerman, Sara P. H. van den Berg, Josien Lanfermeijer

Publikováno v: Medical Microbiology and Immunology, 208(3-4), 365. Springer Verlag
Medical Microbiology and Immunology
Medical Microbiology and Immunology, 208(3-4), 365-373. SPRINGER
Medical Microbiology and Immunology, Springer Verlag, 2019, 208 (3-4), pp.365-373. ⟨10.1007/s00430-019-00608-7⟩

Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a502a31567916bd81b4374bdd81074
http://hdl.handle.net/10029/623049