Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sara Noorani"'
Autor:
Andrew J. Byrne, Sandra A. Bright, James. P. McKeown, Adam Bergin, Brendan Twamley, Anthony M. McElligott, Sara Noorani, Shubhangi Kandwal, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Molecules, Vol 28, Iss 24, p 8095 (2023)
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis and antiproliferative effects of a series of (E)-9-(2-nitro
Externí odkaz:
https://doaj.org/article/4eb2cf5d956c4622b0b26f06f0efdc53
Autor:
Gloria Ana, Patrick M. Kelly, Azizah M. Malebari, Sara Noorani, Seema M. Nathwani, Brendan Twamley, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 169 (2021)
We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7
Externí odkaz:
https://doaj.org/article/c41b78584775460886dc442b2b85cb34
Autor:
Sara Noorani, Shannon R. Nelson, Neil T. Conlon, Justine Meiller, Ekaterina Shcheglova, Alice Usai, Jojanneke Stoof, Letizia Palanga, Fiona O’Neill, Sandra Roche, Maura B. Cotter, Niall Swan, Naomi Walsh
Publikováno v:
Organoids; Volume 1; Issue 2; Pages: 168-183
Pancreatic cancer is a highly lethal disease. Therapeutic resistance to chemotherapy is a major cause of treatment failure and recurrence in pancreatic cancer. Organoids derived from cancer stem cells (CSC) are promising models for the advancement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb5642f7a2d7bd2126e62834b9b9b8e
Publikováno v:
Inorganic Chemistry
The preparation of two polyarginine conjugates of the complex Os(II) [bis-(4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine)] [Os-(Rn)2]x+ (n = 4 and 8; x = 10 and 18) is reported, to explore whether the R8 peptide sequence that promotes cell upta
Autor:
Mary J. Meegan, Daniela M. Zisterer, Darren Fayne, Niamh M. O’Boyle, Brendan Twamley, Azizah M. Malebari, Denise Coutinho Endringer, Elisangela Flavia Pimentel, Patrick M. Kelly, Seema M. Nathwani, Sara Noorani, Gloria Ana
Publikováno v:
Pharmaceuticals, Vol 14, Iss 169, p 169 (2021)
Pharmaceuticals
Volume 14
Issue 2
Pharmaceuticals
Volume 14
Issue 2
We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7
Publikováno v:
Proceedings of 6th International Electronic Conference on Medicinal Chemistry.
Autor:
Sara Noorani, Mary J. Meegan, James Mc Keown, Keith Ferris, Niamh M. O’Boyle, Clara Charleton
Publikováno v:
Proceedings of 4th International Electronic Conference on Medicinal Chemistry.
CLL (Chronic Lymphocytic Leukaemia) is the most common leukaemia in the Western world. Classed as a clonal disorder of mature B-lymphocytes, CLL patient prognoses are broadly subdivided by the mutational status of the Immunoglobulin G Heavy Chain Var
Autor:
Jacintha O'Sullivan, Brendan Twamley, Mary J. Meegan, Azizah M. Malebari, Sara Noorani, Niamh M. O’Boyle, Fiona O'Connell, Daniela M. Zisterer, Darren Fayne, Seema M. Nathwani
Publikováno v:
European Journal of Medicinal Chemistry. 189:112050
A series of novel 1,4-diaryl-2-azetidinone analogues of combretastatin A-4 (CA-4) have been designed, synthesised and evaluated in vitro for antiproliferative activity, antiapoptotic activity and inhibition of tubulin polymerisation. Glucuronidation