Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Sara N. Vallerie"'
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GPIHBP1
Autor: Sara N. Vallerie, Karin E. Bornfeldt
Publikováno v: Circulation Research. 116:560-562
The role of triglyceride-rich lipoproteins (chylomicrons and very low-density lipoproteins [VLDL]) in promoting cardiovascular disease (CVD) has been an area of debate over many years.1 Epidemiological and genetic evidence supports the idea of raised
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f5c91b6085c111ab7b7b7c8bf1802d3
https://doi.org/10.1161/circresaha.115.305819
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3
Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats
Autor: Jamie S. Harmon, Ann V. Hertzel, David A. Bernlohr, Susan D. Parazzoli, Jana Mahadevan, R. Paul Robertson, Melissa Lopez, Elizabeth Oseid, Chang Qin Liu, Sara N. Vallerie
Publikováno v: Diabetes
We reported earlier that β-cell–specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b09e46e34d003c252cb5db905f1487
https://doi.org/10.2337/db13-0357
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4
Myeloid Cell Prostaglandin E2 Receptor EP4 Modulates Cytokine Production but Not Atherogenesis in a Mouse Model of Type 1 Diabetes
Autor: Katrin I. Andreasson, Richard M. Breyer, Sara N. Vallerie, Jenny E. Kanter, Shelley Barnhart, Karin E. Bornfeldt, Farah Kramer
Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0158316 (2016)
Type 1 diabetes mellitus (T1DM) is associated with cardiovascular complications induced by atherosclerosis. Prostaglandin E2 (PGE2) is often raised in states of inflammation, including diabetes, and regulates inflammatory processes. In myeloid cells,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c810e629d62c8775f71f8c4d9a2c7d2b
http://europepmc.org/articles/PMC4924840
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5
Stamp2 Controls Macrophage Inflammation through Nicotinamide Adenine Dinucleotide Phosphate Homeostasis and Protects against Atherosclerosis
Autor: Henrik ten Freyhaus, Zerrin Z. Calay, Ediz S. Calay, Gökhan S. Hotamisligil, Ling Yang, Fahri Saatcioglu, Sara N. Vallerie, Abdullah Yalcin
Publikováno v: Cell Metabolism. 16:81-89
The six-transmembrane protein Stamp2 plays an important role in metabolically-triggered inflammation and insulin action. However, how and in which target cells Stamp2 regulates inflammatory responses and the physiological consequences remain unknown.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0cc663bfec5809d7ce082cccb936cf
https://doi.org/10.1016/j.cmet.2012.05.009
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6
Metabolic Flexibility and Dysfunction in Cardiovascular Cells
Autor: Sara N. Vallerie, Karin E. Bornfeldt
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Cardiovascular cells that contribute directly to atherosclerosis and cardiac dysfunction are known to exhibit metabolic flexibility, characterized by the ability to switch from generating ATP primarily through oxidative phosphorylation to using glyco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6bbb1092a385d0861c9175e2b5a8f
https://doi.org/10.1161/atvbaha.115.306226
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7
Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells
Autor: R. Robertson, Sara N. Vallerie, Jana Mahadevan, Elizabeth Oseid, Ran Meng
Publikováno v: Antioxidants, Vol 5, Iss 4, p 47 (2016)
Antioxidants
Antioxidants; Volume 5; Issue 4; Pages: 47
Silymarin (SIL) is a flavonoid extracted from milk thistle seed that has been reported to decrease hyperglycemia in people with type 2 diabetes (T2D). However, it is not known whether SIL has direct secretory effects on β-cells. Using the β-cell li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfbd1507f6a6880f188a1056e28f6b2
https://doi.org/10.3390/antiox5040047
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8
Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
Autor: Sara N. Vallerie, Jamie S. Harmon, Susan Parazzoli, Huarong Zhou, Tao Zhang, R. Paul Robertson
Publikováno v: The Journal of biological chemistry. 287(38)
Arachidonic acid is converted to prostaglandin E(2) (PGE(2)) by a sequential enzymatic reaction performed by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin E synthases (cPGES, mPGES-1, and mPGES-2). mPGES-1 is wide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6413355849f81d940df049561eac44
https://pubmed.ncbi.nlm.nih.gov/22822059
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10
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
Autor: Gökhan S. Hotamisligil, Raquel Fucho, Sara N. Vallerie, Masato Furuhashi
Publikováno v: PLoS ONE, Vol 3, Iss 9, p e3151 (2008)
PLoS ONE
It has been established that c-Jun N-terminal kinase 1 (JNK1) is essential to the pathogenesis of insulin resistance and type 2 diabetes. Although JNK influences inflammatory signaling pathways, it remains unclear whether its activity in macrophages
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a780288a48ad528f39c7ab2798fd4a6
http://europepmc.org/articles/PMC2528001?pdf=render
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