Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sara N. Andres"'
Autor:
Benhur Amare, Anthea Mo, Noorisah Khan, Dana J. Sowa, Monica M. Warner, Andriana Tetenych, Sara N. Andres
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
DNA double-strand breaks are the most lethal form of damage for living organisms. The non-homologous end joining (NHEJ) pathway can repair these breaks without the use of a DNA template, making it a critical repair mechanism when DNA is not replicati
Externí odkaz:
https://doaj.org/article/d73893c5acb64be99a63598409687c0d
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Lsr2 is a small nucleoid-associated protein found throughout the actinobacteria. Lsr2 functions similarly to the well-studied H-NS, in that it preferentially binds AT-rich sequences and represses gene expression. In Streptomyces venezuelae,
Externí odkaz:
https://doaj.org/article/eb90e39b313e49a499b6c2f469974153
Autor:
Elda Cannavo, Dominic Johnson, Sara N. Andres, Vera M. Kissling, Julia K. Reinert, Valerie Garcia, Dorothy A. Erie, Daniel Hess, Nicolas H. Thomä, Radoslav I. Enchev, Matthias Peter, R. Scott Williams, Matt J. Neale, Petr Cejka
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection
Externí odkaz:
https://doaj.org/article/b5b662ab16c04fe787474e35772256f4
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Alpha-1 antitrypsin (AAT, also known as alpha-1 proteinase inhibitor or SERPINA1) is the most abundant member of the serpin superfamily found in human plasma. The naturally occurring variant AAT M358R, altered at the P1 position of the critical react
Externí odkaz:
https://doaj.org/article/69c66b2ff33a45bfadd5454b86064ee8
Autor:
Tamara Maiuri, Carlos Barba Bazan, Rachel J. Harding, Nola Begeja, Tae-In Kam, Lauren M. Byrne, Filipe B. Rodrigues, Monica M. Warner, Kaitlyn Neuman, Muqtasid Mansoor, Mohsen Badiee, Morgan Dasovich, Anthony K. L. Leung, Sara N. Andres, Edward J. Wild, Ted M. Dawson, Valina L. Dawson, Cheryl H. Arrowsmith, Ray Truant
Huntington’s disease (HD) is an autosomal dominant genetic neurodegenerative disease caused by a CAG expansion in theHuntingtin (HTT)gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset is corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1310ffef06654ba9e95bead255cc3210
https://doi.org/10.1101/2022.11.23.517669
https://doi.org/10.1101/2022.11.23.517669
Autor:
Dana J Sowa, Monica M Warner, Andriana Tetenych, Lucas Koechlin, Pardis Balari, Jose Pablo Rascon Perez, Cody Caba, Sara N Andres
Publikováno v:
Nucleic acids research. 50(19)
Bacterial non-homologous end joining requires the ligase, LigD and Ku. Ku finds the break site, recruits LigD, and then assists LigD to seal the phosphodiester backbone. Bacterial Ku contains a core domain conserved with eukaryotes but has a unique C
Publikováno v:
Journal of Biological Chemistry. 294:3312-3320
The Ctp1 protein in Schizosaccharomyces pombe is essential for DNA double-strand break (DSB) repair by homologous recombination. Fission yeast Ctp1 and its budding yeast (Sae2) and human (CtIP) homologs control Mre11–Rad50–Nbs1 nuclease complex a
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine
Alpha-1 antitrypsin (AAT, also known as alpha-1 proteinase inhibitor or SERPINA1) is the most abundant member of the serpin superfamily found in human plasma. The naturally occurring variant AAT M358R, altered at the P1 position of the critical react
Publikováno v:
The Journal of biological chemistry. 295(3)
The Ctp1 protein in Schizosaccharomyces pombe is essential for DNA double-strand break (DSB) repair by homologous recombination. Fission yeast Ctp1 and its budding yeast (Sae2) and human (CtIP) homologs control Mre11–Rad50–Nbs1 nuclease complex a
Autor:
Christopher J. Bergin, Kinga Vojnits, Borko Tanasijevic, Zoya Shapovalova, Deanna P. Porras, Aïcha Zouggar, Meaghan Doyle, Luca Orlando, Angelique N. Masibag, Kalinka Koteva, Juan L. García-Rodríguez, Jagdish Suresh Patel, Jennifer Russell, Allison L. Boyd, Wenliang Wang, Ryan R. Mitchell, Tony J. Collins, Lili Aslostovar, Mickie Bhatia, Jakob Magolan, Gerard D. Wright, Yannick D. Benoit, Fanny L. Casado, Lakshmana K. Kinthada, Justin D. Lu, Sara N. Andres, Cody Caba
Publikováno v:
Cell Chem Biol
Summary Natural products (NPs) encompass a rich source of bioactive chemical entities. Here, we used human cancer stem cells (CSCs) in a chemical genomics campaign with NP chemical space to interrogate extracts from diverse strains of actinomycete fo