Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Sara N Richter"'
Autor:
Enrico Lavezzo, Michele Berselli, Ilaria Frasson, Rosalba Perrone, Giorgio Palù, Alessandra R Brazzale, Sara N Richter, Stefano Toppo
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006675 (2018)
G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key
Externí odkaz:
https://doaj.org/article/c648b46eb4964041aafca1d8e2d27290
Autor:
Giovanna Sattin, Anna Artese, Matteo Nadai, Giosuè Costa, Lucia Parrotta, Stefano Alcaro, Manlio Palumbo, Sara N Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84113 (2013)
Telomeres are guanine-rich sequences that protect the ends of chromosomes. These regions can fold into G-quadruplex structures and their stabilization by G-quadruplex ligands has been employed as an anticancer strategy. Genetic analysis in human telo
Externí odkaz:
https://doaj.org/article/0aa5f76182e54237b1cbacc3382d07da
Autor:
Rosalba Perrone, Matteo Nadai, Jerrod A Poe, Ilaria Frasson, Manlio Palumbo, Giorgio Palù, Thomas E Smithgall, Sara N Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73121 (2013)
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have
Externí odkaz:
https://doaj.org/article/24f856fea414412cadb23b059038d14d
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52994 (2012)
Non-canonical DNA structures have been postulated to mediate protein-nucleic acid interactions and to function as intermediates in the generation of frame-shift mutations when errors in DNA replication occur, which result in a variety of diseases and
Externí odkaz:
https://doaj.org/article/7fae12d419404a33899bce607f06a450
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9523
Guanine quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine (G)-rich tracts that assemble into a core of stacked planar tetrads. G4s are found in the human genome and in the genomes of human pathogens, where they are involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8b31078079ae2f039928b428114ba7
Autor:
Emanuela Ruggiero, Ilaria Frasson, Elena Tosoni, Matteo Scalabrin, Rosalba Perrone, Maja Marušič, Janez Plavec, Sara N. Richter
Publikováno v:
ACS Infectious Diseases. 8:958-968
HIV-1 integrated long terminal repeat (LTR) promoter activity is modulated by folding of its G-rich region into non-canonical nucleic acids structures, such as G-quadruplexes (G4s), and their interaction with cellular proteins. Here, by a combined pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b24e31b462627b2c204730839e61eb0
https://doi.org/10.1021/acsinfecdis.1c00508
https://doi.org/10.1021/acsinfecdis.1c00508
Publikováno v:
International Journal of Biological Macromolecules. 204:89-102
In human cells, nucleic acids adopt several non-canonical structures that regulate key cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in guanine-rich regions in vitro and in cells. G4 folded/unfolded state shapes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2320ebfe028f7c446cf5435920d8e624
https://doi.org/10.1016/j.ijbiomac.2022.01.197
https://doi.org/10.1016/j.ijbiomac.2022.01.197
Autor:
Ilaria Frasson, Linda Diamante, Manuela Zangrossi, Elena Carbognin, Anna Dalla Pietà, Alessandro Penna, Antonio Rosato, Ranieri Verin, Filippo Torrigiani, Cristiano Salata, Lorenzo Vaccaro, Davide Cacchiarelli, Sara N. Richter, Marco Montagner, Graziano Martello
The high mutation rate of SARS-CoV-2 leads to emergence of several variants, some of which are resistant to vaccines and drugs targeting viral elements. Targeting host dependency factors – cell proteins required for viral replication - would help a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::515f46a09145a14620b9eca07fd8c785
https://doi.org/10.1101/2023.01.09.523209
https://doi.org/10.1101/2023.01.09.523209
Autor:
Francesca Scionti, Giada Juli, Roberta Rocca, Nicoletta Polerà, Matteo Nadai, Katia Grillone, Daniele Caracciolo, Caterina Riillo, Emanuela Altomare, Serena Ascrizzi, Basilio Caparello, Maria Cerra, Mariamena Arbitrio, Sara N. Richter, Anna Artese, Stefano Alcaro, Pierosandro Tagliaferri, Pierfrancesco Tassone, Maria Teresa Di Martino
Background Multiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability, and telomere dysfunction is an important cause of acquired genomic alterations. Telomeric repeat-containing RNA (TERRA) transcripts are long non-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc800b28995aea68adb929223dfbece8
https://hdl.handle.net/11577/3479314
https://hdl.handle.net/11577/3479314
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
G-quadruplexes (G4s) are four-stranded nucleic acid structures abundant at gene promoters. They can adopt several distinctive conformations. G4s have been shown to form in the herpes simplex virus-1 (HSV-1) genome during its viral cycle. Here by cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de693ca796e35479f161f8699075bb1
https://doaj.org/article/943c4355795a4746b380351fd6fd43ff
https://doaj.org/article/943c4355795a4746b380351fd6fd43ff