An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples

Autor: Eleonora Ciarlo, Sara Massone, Ilaria Penna, Mario Nizzari, Arianna Gigoni, Giorgio Dieci, Claudio Russo, Tullio Florio, Ranieri Cancedda, Aldo Pagano

Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 2, Pp 424-433 (2013)

SUMMARY Recent studies indicated that sortilin-related receptor 1 (SORL1) is a risk gene for late-onset Alzheimer's disease (AD), although its role in the aetiology and/or progression of this disorder is not fully understood. Here, we report the find

Externí odkaz: https://doaj.org/article/ce060c0f1dbf4dbd921ea90c750f34f1

17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease

Autor: Sara Massone, Irene Vassallo, Gloria Fiorino, Manuele Castelnuovo, Federica Barbieri, Roberta Borghi, Massimo Tabaton, Mauro Robello, Elena Gatta, Claudio Russo, Tullio Florio, Giorgio Dieci, Ranieri Cancedda, Aldo Pagano

Publikováno v: Neurobiology of Disease, Vol 41, Iss 2, Pp 308-317 (2011)

Alternative splicing is a central component of human brain complexity; nonetheless, its regulatory mechanisms are still largely unclear. In this work, we describe a novel non-coding (nc) RNA (named 17A) RNA polymerase (pol) III-dependent embedded in

Externí odkaz: https://doaj.org/article/86e6db654bc14977b656f5a4e3fe1545

The Murine PSE/TATA-Dependent Transcriptome: Evidence of Functional Homologies with Its Human Counterpart

Autor: Giorgio Dieci, Carolina Balbi, Sara Massone, Federico Villa, Paola Gavazzo, Maria Jessica Bruzzone, Anastasia Conti, Aldo Pagano, Ranieri Cancedda

Publikováno v: International Journal of Molecular Sciences, Vol 13, Iss 11, Pp 14813-14827 (2012)
International journal of molecular sciences (Online) 13 (2012): 14813–14827. doi:10.3390/ijms131114813
info:cnr-pdr/source/autori:Bruzzone MJ; Gavazzo P; Massone S; Balbi C; Villa F; Conti A; Dieci G; Cancedda R; Pagano A/titolo:The Murine PSE%2FTATA-Dependent Transcriptome: Evidence of Functional Homologies with Its Human Counterpart/doi:10.3390%2Fijms131114813/rivista:International journal of molecular sciences (Online)/anno:2012/pagina_da:14813/pagina_a:14827/intervallo_pagine:14813–14827/volume:13
International Journal of Molecular Sciences
Volume 13
Issue 11
Pages 14813-14827

A series of recent studies demonstrated an unexpectedly high frequency of intronic RNA polymerase (pol) III transcription units spread throughout the human genome. The investigation of a subset of these transcripts revealed their tissue/cell-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0bfc6d0a2deab8e088d6e2fd7424f4
https://doi.org/10.3390/ijms131114813

Microarray Analysis in Alzheimer's Disease and Normal Aging

Autor: Cristina d'Abramo, Roberta Ricciarelli, Umberto M. Marinari, Massimo Tabaton, Sara Massone, Maria Adelaide Pronzato

Publikováno v: IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 56:349-354

The purpose of this study was to investigate gene expression in Alzheimer's disease (AD), the most common form of senile dementia. We utilized the microarray technology to simultaneously compare the expression profile of 12,000 human genes in cerebra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1cb1ba54847a63b56b86678402b2f0
https://doi.org/10.1080/15216540412331286002

RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration

Autor: Elena Gatta, Claudio Russo, Mauro Robello, Massimo Tabaton, Aldo Pagano, Roberta Borghi, Giorgio Dieci, Manuele Castelnuovo, Irene Vassallo, Sara Massone, Ranieri Cancedda, Gloria Fiorino

Publikováno v: The Journal of Cell Biology

An RNA polymerase III–transcribed noncoding RNA promotes alternative splicing of KCNIP4, altering amyloid precursor protein processing and contributing to neurodegeneration.
Alternative splicing generates protein isoforms that are conditionall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f39ea0a6dd26ef9244932f3d94482a
http://hdl.handle.net/11695/4612