First‐in‐Human Single‐Ascending‐Dose, Multiple‐Dose, and Food Interaction Studies of NRD.E1, an Innovative Nonopioid Therapy for Painful Diabetic Peripheral Neuropathy

Autor: Eva, Tiecke, Maurizio, Rainisio, Theodor, Guentert, Stephan, Müller, Liat, Hochman, Eli, Kaplan, Sara, Mangialaio

Publikováno v: Clinical Pharmacology in Drug Development. 11:1012-1027

Painful diabetic peripheral neuropathy is characterized by burning, stabbing, or electric shock-type pain, which severely impacts day-to-day functioning and quality of life. Here, we report the results of 3 phase I studies with NRD135S.E1 (referred t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e83d963642dbf2a7b8caf0f6c7dc5e
https://doi.org/10.1002/cpdd.1103

Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies

Autor: Dale Mohar, Bruce G. Martin, Denis Bourrelly, Charles P. Andrews, Frank C. Hampel, Jay van Bavel, Paul H. Ratner, Sara Mangialaio, Parisa Danaietash, Abdel Hmissi, Jasper Dingemanse

Publikováno v: Allergy, Asthma & Clinical Immunology, Vol 13, Iss 1, Pp 1-15 (2017)
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

Background Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present findings on the efficacy and sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77ad6a736fb458ab7740c99c376cdcf
https://doi.org/10.1186/s13223-017-0183-z

Protein microarray platform for the multiplex analysis of biomarkers in human sera

Autor: Christophe Zickler, Sara Mangialaio, Paul Hasler, Teresa Urbanowska, Francois Legay, Sirinda Cheevapruk, Stephan Regenass

Publikováno v: Journal of Immunological Methods. 316:1-7

Many biomarkers are currently used to monitor patients in clinical studies. Technologies which evaluate, validate and monitor biomarkers in a cost effective and efficient manner are a necessity. Here we describe the development, validation and implem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d57f07ef4428c26c50712d7e86a6c36
https://doi.org/10.1016/j.jim.2006.03.019

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis

Autor: Valerie Kouskoff, Sara Mangialaio, Diane Mathis, Christophe Benoist, Anne-Sophie Korganow, Hong Ji

Publikováno v: Arthritis & Rheumatism. 42:2517-2523

Objective. Spontaneous arthritis in the KRN transgenic mouse model is due to the autoreactivity of the transgenic T cell receptor (TCR) against A g7 major histocompatibility complex (MHC) molecules, which leads to strong but incomplete clonal deletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415db7d3e733ece47a796d0379ed2094
https://doi.org/10.1002/1529-0131(199912)42:12<2517::aid-anr3>3.0.co

Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems

Autor: Hong Ji, Anne-Sophie Korganow, Sara Mangialaio, Petter Höglund, Laurent Poirot, Diane Mathis, Isabelle André, Christophe Benoist, Fred Lühder, Antonio Gonzalez

Publikováno v: Immunological Reviews
Immunological Reviews, 1999, 169, pp.139-146. ⟨10.1111/j.1600-065x.1999.tb01312.x⟩

International audience; T lymphocytes constantly flirt with reactivity to self peptides, a price they pay for their ability to recognize foreign peptides presented by self-MHC molecules, and autoreactivity in the T compartment occasionally gives rise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca07cae9ed57c9f16a47b0373c7be75b
https://pubmed.ncbi.nlm.nih.gov/10450514