Výsledky vyhledávání - "Sara M. de la Harpe"

Akademický článek

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

Autor: Rajesh Lamichhane, Marion Schneider, Sara M. de la Harpe, Thomas W.R. Harrop, Rachel F. Hannaway, Peter K. Dearden, Joanna R. Kirman, Joel D.A. Tyndall, Andrea J. Vernall, James E. Ussher

Publikováno v: Cell Reports, Vol 28, Iss 12, Pp 3061-3076.e5 (2019)

Summary: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines. These two modes of activation may a

Externí odkaz: https://doaj.org/article/e7d3730a5cdd4c89b53276250d6d3a1f

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Akademický článek

Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines

Autor: Caitlin R. M. Oyagawa, Sara M. de la Harpe, Yurii Saroz, Michelle Glass, Andrea J. Vernall, Natasha Lillia Grimsey

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Cannabinoid receptor 2 (CB2) is predominantly distributed in immune tissues and cells and is a promising therapeutic target for modulating inflammation. In this study we designed and synthesised a series of 2,4,6-trisubstituted 1,3,5-triazines with p

Externí odkaz: https://doaj.org/article/a08c2b3fe167405d8ce78072d9e54fd9

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Neutrophils suppress mucosal‐associated invariant T cells in humans

Autor: Andrea J. Vernall, James E. Ussher, Joel D. A. Tyndall, Marion Schneider, Rachel F. Hannaway, Anthony J. Kettle, Sara M. de la Harpe, Rajesh Lamichhane

Publikováno v: European Journal of Immunology. 50:643-655

Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1387a45580576d0a55ed5392d5c7e39a
https://doi.org/10.1002/eji.201948394

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Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future

Autor: Zak M. Whiting, Jiazhen Yin, Sara M. de la Harpe, Andrea J. Vernall, Natasha L. Grimsey

Publikováno v: Trends in pharmacological sciences. 43(9)

Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f9f1f2db394124088c96828ba34d98
https://pubmed.ncbi.nlm.nih.gov/35906103

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Human liver-derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR-independent activation

Autor: John L. McCall, Andrea J. Vernall, Thomas W. R. Harrop, Rajesh Lamichhane, Fran Munro, Peter K. Dearden, Sara M. de la Harpe, James E. Ussher

Publikováno v: European journal of immunologyReferences. 51(4)

Mucosal associated invariant T (MAIT) cells are anti-microbial innate-like T cells that are abundant in blood and liver. MAIT cells express a semi-invariant T-cell receptor (TCR) that recognizes a pyrimidine ligand, derived from microbial riboflavin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9bf88b7f2031bab4892ea609f4d1e0
https://pubmed.ncbi.nlm.nih.gov/33368232

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Type I interferons are important co-stimulatory signals during T cell receptor mediated MAIT cell activation

Autor: Henry D. Galvin, Sara M. de la Harpe, Rajesh Lamichhane, Fran Munro, Rachel F. Hannaway, John L. McCall, Matloob Husain, James E. Ussher, Joel Da Tyndall, Andrea J. Vernall

Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells which can be stimulated either via their T cell receptor (TCR) or by innate cytokines. The MAIT cell TCR recognises a pyrimidine ligand, derived from riboflavin synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34012f11c68cb2b706cae20c4da8fad
https://doi.org/10.1101/686170

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Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation

Autor: Henry D. Galvin, Andrea J. Vernall, James E. Ussher, John L. McCall, Sara M. de la Harpe, Matloob Husain, Joel Da Tyndall, Rajesh Lamichhane, Fran Munro, Rachel F. Hannaway

Publikováno v: European journal of immunologyReferences. 50(2)

Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that can be stimulated either via their TCR or by innate cytokines. The MAIT cell TCR recognises a pyrimidine ligand, derived from riboflavin synthesising bacteria, bound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528180278884c8f2201c84ba2cb0e17f
https://pubmed.ncbi.nlm.nih.gov/31608441

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Transcriptional analysis defines TCR and cytokine-stimulated MAIT cells as rapid polyfunctional effector T cells that can coordinate the immune response

Autor: Peter K. Dearden, Thomas W. R. Harrop, Joel D. A. Tyndall, James E. Ussher, Joanna R. Kirman, Sara M. de la Harpe, Andrea J. Vernall, Rachel F. Hannaway, Marion Schneider, Rajesh Lamichhane

MAIT cells are an abundant innate-like T cell population which can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidine antigens derived from microbial riboflavin biosynthesis, or via cytokines, such as IL-12 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29370b7cd77a1e276b86def5b6e7b941
https://doi.org/10.1101/600189

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