3D printed hybrid scaffolds for bone regeneration using calcium methoxyethoxide as a calcium source

Autor: Agathe Heyraud, Francesca Tallia, David Sory, Hung-Kai Ting, Anna Tchorzewska, Jingwen Liu, Hannah L. Pilsworth, Peter D. Lee, John V. Hanna, Sara M. Rankin, Julian R. Jones

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Introduction: Hybrids consist of inorganic and organic co-networks that are indistinguishable above the nanoscale, which can lead to unprecedented combinations of properties, such as high toughness and controlled degradation.Methods: We present 3D pr

Externí odkaz: https://doaj.org/article/be0fd93a3054418492dda20a27fe66a0

Hybrid materials with continuous mechanical property gradients that can be 3D printed

Autor: Gloria Young, Francesca Tallia, Jeffrey N. Clark, Manishankar Chellappan, Oriol Gavalda-Diaz, Enric Juan Alcocer, Silvia A. Ferreira, Sara M. Rankin, Joshua P. Clark, John V. Hanna, Jonathan R.T. Jeffers, Julian R. Jones

Publikováno v: Materials Today Advances, Vol 17, Iss , Pp 100344- (2023)

Here, we show tough materials with continuous composition and stiffness gradients, without interfaces between regions, using inorganic/organic hybrid materials that can also be 3D printed. Sol-gel hybrid materials have interacting and interpenetratin

Externí odkaz: https://doaj.org/article/0ac61ad518694336b6b7c0fcc596a5ae

Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms

Autor: Andia N. Redpath, Moïra François, Suet-Ping Wong, Dominique Bonnet, Sara M. Rankin

Publikováno v: Blood Advances, Vol 1, Iss 22, Pp 1934-1943 (2017)

Abstract: Pharmacological mobilization of hematopoietic progenitor cells (HPCs) is used clinically to harvest HPCs for bone marrow transplants. It is now widely accepted that the CXCR4:CXCL12 chemokine axis plays a critical role in the retention of H

Externí odkaz: https://doaj.org/article/5e532f57c7814c2c8eeec117d7668c4a

Poly(2‐(dimethylamino) ethyl methacrylate)‐ b ‐poly(lauryl methacrylate)‐ b ‐poly(oligo ethylene glycol methacrylate) triblock terpolymer micelles as drug delivery carriers for curcumin

Autor: Athanasios Skandalis, Dimitrios Selianitis, David R. Sory, Sara M. Rankin, Julian R. Jones, Stergios Pispas

Publikováno v: Journal of Applied Polymer Science. 139

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc9ed86e7aa39ef1ff85304ed254e310
https://doi.org/10.1002/app.52899

Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

Autor: Sara M. Rankin, Viktorija Daugvilaite, Katia De Filippo, Goda Juzenaite, Astrid Sissel Jørgensen, Mette M. Rosenkilde, Maša Mavri, Christian Berg, Tau Benned-Jensen, Gertrud Malene Hjortø, Jon Våbenø

Publikováno v: Communications Biology
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.

Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc85e58203949fdd2febe45ee002aba4
http://hdl.handle.net/10044/1/88841