Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sara M. Parigi"'
Autor:
Sara M. Parigi, Ludvig Larsson, Srustidhar Das, Ricardo O. Ramirez Flores, Annika Frede, Kumar P. Tripathi, Oscar E. Diaz, Katja Selin, Rodrigo A. Morales, Xinxin Luo, Gustavo Monasterio, Camilla Engblom, Nicola Gagliani, Julio Saez-Rodriguez, Joakim Lundeberg, Eduardo J. Villablanca
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract The intestinal barrier is composed of a complex cell network defining highly compartmentalized and specialized structures. Here, we use spatial transcriptomics to define how the transcriptomic landscape is spatially organized in the steady s
Externí odkaz:
https://doaj.org/article/f5256a2864b448d09abb930e673fd1f1
Autor:
Paulo Czarnewski, Sara M. Parigi, Chiara Sorini, Oscar E. Diaz, Srustidhar Das, Nicola Gagliani, Eduardo J. Villablanca
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Clinical and molecular heterogeneity of ulcerative colitis presents unresolved challenges to identify predictive biomarkers of response to therapies. Here, the authors combine mouse colitis time course with patient biopsy transcriptomes, achieving un
Externí odkaz:
https://doaj.org/article/d46d311b84244bbf8766ebda31a8df22
Autor:
Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M. Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R. Izbicki, Ansgar W. Lohse, Richard A. Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo, Eduardo J. Villablanca, Nicola Gagliani, Samuel Huber
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within
Externí odkaz:
https://doaj.org/article/9965d7bfb0694a05899ad6316109497d
Publikováno v:
Nutrients, Vol 9, Iss 1, p 68 (2017)
Vitamin A (VA) is amongst the most well characterized food-derived nutrients with diverse immune modulatory roles. Deficiency in dietary VA has not only been associated with immune dysfunctions in the gut, but also with several systemic immune disord
Externí odkaz:
https://doaj.org/article/4d5ad540c5804abfbcb78084e918cdee
Autor:
Rodrigo A. Morales, Soraya Rabahi, Oscar E. Diaz, Yazan Salloum, Bianca C. Kern, Mikaela Westling, Xinxin Luo, Sara M. Parigi, Gustavo Monasterio, Srustidhar Das, Pedro P. Hernández, Eduardo J. Villablanca
Publikováno v:
Mucosal Immunology. 15:940-951
Autor:
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil
Publikováno v:
Immunity
Summary Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets that can exhibit different activation stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e770400b45d09bc1c521b560ca507e8e
Autor:
Srustidhar Das, Sara M. Parigi, Camilla Engblom, Kumar Parijat Tripathi, Julio Saez-Rodriguez, Rodrigo A. Morales, Annika Frede, Joakim Lundeberg, Xinxin Luo, Oscar E. Diaz, Monasterio G, Eduardo J. Villablanca, Ludvig Larsson, Nicola Gagliani, Selin K, Ramirez Flores Ro
The intestinal barrier is composed of a complex cell network defining highly compartmentalized and specialized structures. Here, we use spatial transcriptomics (ST) to define how the transcriptomic landscape is spatially organized in the steady state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fef58937bcfdd88a7476a10f3cace970
https://doi.org/10.1101/2021.07.01.450768
https://doi.org/10.1101/2021.07.01.450768
Autor:
Chiara Sorini, Eduardo J. Villablanca, Paulo Czarnewski, Oscar E. Diaz, Nicola Gagliani, Sara M. Parigi, Srustidhar Das
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Clinical manifestations and response to therapies in ulcerative colitis (UC) are heterogeneous, yet patient classification criteria for tailored therapies are currently lacking. Here, we present an unsupervised molecular classification of UC patients
Autor:
Jonathan M. Coquet, Anne-Laure Joly, Katrin Klocke, Lisa S. Westerberg, Kajsa Wing, John Andersson, Paulo Czarnewski, Sara M. Parigi, Eduardo J. Villablanca, Christopher A. Tibbitt, Sang Liu, Christina Seitz
Publikováno v:
Journal of Autoimmunity. 98:86-94
CTLA-4 is required for CD4+Foxp3+ regulatory T (Treg) cell function, but its mode of action remains incompletely defined. Herein we generated Ctla-4ex2fl/flFoxp3-Cre mice with Treg cells exclusively expressing a naturally occurring, ligand-independen
Autor:
Anna Färnert, Thomas Jacobs, Leonie Brockmann, Marianne Forkel, Paulo Czarnewski, Eduardo J. Villablanca, Sara M. Parigi, Lisa S. Westerberg, Samuel Huber, Jenny Mjösberg, Victor Yman, Charlotte Höög, Sara Fernandez-Gaitero, Christiane Steeg, Srustidhar Das
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
A common helper-like innate lymphoid precursor (CHILP) restricted to the innate lymphoid cells (ILC) lineage has been recently characterized. While specific requirements of transcription factors for CHILPs development has been partially described, th