Zobrazeno 1 - 1
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pro vyhledávání: '"Sara M. Pérez Benedicto"'
Autor:
Mari Luz Rosauro, Kris Van Dijck, Gregory Fanning, David McGowan, Sara M. Pérez Benedicto, Bart Stoops, Pierre Jean-Marie Bernard Raboisson, Bertrand Van Schoubroeck, Wendy Mostmans, Annick Scholliers, Tine Thoné, Frederik Pauwels, Mourad Daoubi Khamlichi, Vineet Pande, Tim H. M. Jonckers, Florence Herschke, Helen Horton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3216-3221
In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure-activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high cl