Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sara M. Hall"'
Autor:
Frank Porreca, John M. Streicher, Jessica Hanson, Tally M. Largent-Milnes, Peg Davis, Alexander J. Sandweiss, Todd W. Vanderah, Sara M. Hall, Victor J. Hruby, Cyf Ramos-Colon, Justin LaVigne, Yeon Sun Lee, Mary I. McIntosh, Michael Remesic
Publikováno v:
Journal of Medicinal Chemistry. 59:10291-10298
Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference for the κ opioid receptor (KOR), and its structure-activity relationship (SAR) has been extensively studied at the KOR to develop selective potent agonists and anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc72edbd5c3b18ba2b36c2e01f86dea
https://doi.org/10.1021/acs.jmedchem.6b01411
https://doi.org/10.1021/acs.jmedchem.6b01411
Autor:
Frank Porreca, David Rankin, Alexander Kuzmin, Josephine Lai, Michael Remesic, Victor J. Hruby, Sara M. Hall, Cyf Ramos-Colon, Yeon Sun Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5513-5516
Nerve injury and inflammation cause up-regulation of an endogenous opioid ligand, dynorphin A (Dyn A), in the spinal cord resulting in hyperalgesia via the interaction with bradykinin receptors (BRs). This is a non-opioid neuroexcitatory effect that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bc6444d737c153bd609fe34ad9b60b
https://doi.org/10.1016/j.bmcl.2016.10.010
https://doi.org/10.1016/j.bmcl.2016.10.010
Autor:
Frank Porreca, Chaoling Qu, Lindsay LeBaron, Yeon Sun Lee, Cyf Ramos-Colon, Victor J. Hruby, Jennifer Y. Xie, Sara M. Hall, Josephine Lai
Publikováno v:
ACS Chemical Neuroscience. 7:1746-1752
Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919cd1c40e2825eec312b2b397bea5ad
https://doi.org/10.1021/acschemneuro.6b00258
https://doi.org/10.1021/acschemneuro.6b00258
Autor:
Frank Porreca, Victor J. Hruby, Michael Remesic, Christopher Chan, David Rankin, Cyf Ramos-Colon, Yeon Sun Lee, Robert Kupp, Sara M. Hall, Josephine Lai
Publikováno v:
Chemical Biology & Drug Design. 88:615-619
As a unique endogenous opioid ligand, dynorphin A shows paradoxical neuroexcitatory effects at bradykinin receptors, and the effects are known to be amplified by the upregulation of dynorphin A under chronic pain and inflammatory conditions. In our e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7271ba4894aa7fe3dfedfc130ddf9e18
https://doi.org/10.1111/cbdd.12789
https://doi.org/10.1111/cbdd.12789
Autor:
Ann Nguyen, Michael Remesic, Frank Porreca, Victor J. Hruby, David Rankin, Cyf Ramos-Colon, Lindsay LeBaron, Yeon Sun Lee, Sara M. Hall, Josephine Lai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:30-33
It has been shown that under chronic pain or nerve injury conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) to cause hyperalgesia in the spinal cord. Thus BRs antagonist can modulate hyperalgesia by blocking Dyn A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c07cfebda0e4078ede1b61566162e4e
https://doi.org/10.1016/j.bmcl.2014.11.026
https://doi.org/10.1016/j.bmcl.2014.11.026
Autor:
David Rankin, Jennifer Y. Xie, Alexander J. Sandweiss, Sara M. Hall, Todd W. Vanderah, Milena De Felice, Josephine Lai, Jackie Hu, Cyf Ramos-Colon, Yeon Sun Lee, Victor J. Hruby, Dhanasekaran Muthu, Frank Porreca
Publikováno v:
Journal of the American Chemical Society
We hypothesized that under chronic pain conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) in the spinal cord to promote hyperalgesia through an excitatory effect, which is opposite to the well-known inhibitory eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af3efa01dc0e9d49bfc71ba72ea88ab
https://doi.org/10.1021/ja501677q
https://doi.org/10.1021/ja501677q
Autor:
Cyf N, Ramos-Colon, Yeon Sun, Lee, Michael, Remesic, Sara M, Hall, Justin, LaVigne, Peg, Davis, Alexander J, Sandweiss, Mary I, McIntosh, Jessica, Hanson, Tally M, Largent-Milnes, Todd W, Vanderah, John, Streicher, Frank, Porreca, Victor J, Hruby
Publikováno v:
Journal of medicinal chemistry. 59(22)
Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference for the κ opioid receptor (KOR), and its structure–activity relationship (SAR) has been extensively studied at the KOR to develop selective potent agonists and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::416eb90ee5c6349a54f12e37f2e21930
https://pubmed.ncbi.nlm.nih.gov/27797517
https://pubmed.ncbi.nlm.nih.gov/27797517
Chronic pain is one of the most ubiquitous diseases in the world, but treatment is difficult with conventional methods, due to undesirable side effects of treatments and unknown mechanisms of pathological pain states. The endogenous peptide, dynorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9adbee70c4f66da48e7f0bc2f62f00f
https://europepmc.org/articles/PMC4976860/
https://europepmc.org/articles/PMC4976860/
Autor:
Cyf Ramos-Colon, Frank Porreca, Michael Remesic, Yeon Sun Lee, Victor J. Hruby, Sara M. Hall, David Rankin, Josephine Lai, Todd W. Vanderah
Publikováno v:
Receptors & Clinical Investigation.
Dynorphin A (Dyn A) is an endogenous opioid ligand that possesses neuroinhibitory (antinociceptive) effects via μ, δ, and κ opioid receptors. However, under chronic pain conditions, up-regulated spinal Dyn A can also interact with bradykinin recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c7bd9e540531a2f3eab7bf335fad44
https://doi.org/10.14800/rci.517
https://doi.org/10.14800/rci.517
Autor:
Frank Porreca, Sara M. Hall, Josephine Lai, Victor J. Hruby, Cyf Nadine Ramos Colón, Yeon Sun Lee
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
Neuropathic pain effects 100 million Americans and imposes a significant public health problem. This type of pain results from the dysfunction of the central nervous system (CNS) or the peripheral nervous system (PNS) that can occur in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3ba55347a5f2d9ff8b8319bc77a42fa
https://doi.org/10.17952/24aps.2015.071
https://doi.org/10.17952/24aps.2015.071