Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Sara Little"'
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Abstract P3-11-13: Synergistic inhibition of MCF-7 mammary gland tumor growth with Piqray® (alpelisib) plus SDX-7320, a novel polymer-conjugated methionine aminopeptidase 2 (MetAP2) inhibitor
Autor: Andrew Slee, James Shanahan, Bradley Carver, Adam Nir, Peter Cornelius, Benjamin Mayes, Sara Little, Nir Raphael
Publikováno v: Cancer Research. 80:P3-11
Mutations in the PI3K pathway have been observed in about 40% of ER+/Her2- breast cancer patients. Amplification as well as mutation of the catalytic p110α subunit of PI3K results in activation of this pathway within tumors, conferring a growth adva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47c8eb04d5dad70aa8785198cca92fac
https://doi.org/10.1158/1538-7445.sabcs19-p3-11-13
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2
Abstract P5-05-04: Inhibition of HER2+ tumor growth with SDX-7320, a novel MetAP2 inhibitor, alone and in combination with capivasertib/AZD-5363: Reduced expression of hypoxia-inducible and innate-immune system genes
Autor: Peter Cornelius, Benjamin Mayes, Pierre Dufour, Mark Kalinich, Jonathan Wang, Sara Little, Bradley Carver, James Shanahan
Publikováno v: Cancer Research. 82:P5-05
MetAP2 inhibitors have shown clinical anti-tumor activity, but CNS side effects and poor drug-like properties have generally limited their development. SDX-7320 is a polymer-drug conjugate of a novel fumagillin-derived MetAP2 inhibitor (SDX-7539) att
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3acd3caae394c2610c6df0d9c4996bc4
https://doi.org/10.1158/1538-7445.sabcs21-p5-05-04
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3
Abstract 1068: SDX-7320, a novel inhibitor of methionine aminopeptidase 2 (MetAP2), inhibits MCF-7 tumor growth in combination with palbociclib (Ibrance®)
Autor: Adam Nir, Benjamin Mayes, Nir Raphael, Bradley Carver, Peter Cornelius, Sara Little, Andrew Slee, Pierre Dufour, James Shanahan
Publikováno v: Cancer Research. 81:1068-1068
Small molecule MetAP2 inhibitor TNP-470 previously showed clinical anti-tumor activity, however CNS side effects and poor drug-like properties limited its development. SDX-7320 is a polymer-drug conjugate of a novel MetAP2 inhibitor (SDX-7539), inten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dedc8be0e478169de40906631fc23fb1
https://doi.org/10.1158/1538-7445.am2021-1068
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4
Abstract 1226: A novel polymer-conjugated methionine aminopeptidase 2 (MetAP2) inhibitor SDX-7320 inhibits the growth of EO771 mammary gland tumors and ameliorates the immunosuppressive tumor immune micro-environment (TIME)
Autor: Peter Cornelius, James Shanahan, Bradley Carver, Sara Little, David J. Turnquist, Andrew Slee, Benjamin Mayes
Publikováno v: Cancer Research. 79:1226-1226
Obese patients with certain cancers face a greater risk of dying from their cancer compared to non-obese patients. Obesity may contribute to cancer progression via multiple mechanisms: increased leptin, decreased adiponectin, increased adipose tissue
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d24cfeb04d3e1c74e81291b9ab8ecf
https://doi.org/10.1158/1538-7445.am2019-1226
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5
Abstract 4919: Preclinical activity of SDX-7320 in mouse models of obesity and obesity-driven cancer
Autor: Andrew Slee, Bradley Carver, Benjamin Mayes, Peter Cornelius, Alfred Anderson-Villaluz, James Shanahan, Robert J. Lutz, Petersen John S, David J. Turnquist, Sara Little, Kimberly Sullivan
Publikováno v: Cancer Research. 78:4919-4919
Cancer patients who are obese face a greater risk of dying from cancer compared to nonobese patients (Calle, 2003). Obesity is believed to contribute to metastasis and progression of cancer via multiple mechanisms: increased secretion of the adipose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d36aa290c5ac9ac7c85694de67f0acb
https://doi.org/10.1158/1538-7445.am2018-4919
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6
Elektronická kniha
Wendi McLendon-Covey 47 Success Facts - Everything You Need to Know About Wendi McLendon-Covey
Autor: Sara Little
A Testament To Wendi McLendon-Covey. This book is your ultimate resource for Wendi McLendon-Covey. Here you will find the most up-to-date 47 Success Facts, Information, and much more.In easy to read chapters, with extensive references and links to ge
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