Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sara Light"'
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005375 (2017)
De novo creation of protein coding genes involves the formation of short ORFs from noncoding regions; some of these ORFs might then become fixed in the population. These orphan proteins need to, at the bare minimum, not cause serious harm to the orga
Externí odkaz:
https://doaj.org/article/01e2219dd84c4157b6cdee7c6ef729b7
Autor:
Per Warholm, Sara Light
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154059 (2016)
A large portion of the coding capacity of Mycobacterium tuberculosis is devoted to the production of proteins containing several copies of the pentapeptide-2 repeat, namely the PE/PPE_MPTR proteins. Protein domain repeats have a variety of binding pr
Externí odkaz:
https://doaj.org/article/c6b98ca6b7114b6d8d8da4af73756378
Autor:
Martin O. Bergo, Pär G. Engström, Maria Schaufelberger, Thomas Gilljam, Martin G. Dalin, Bert Andersson, Emil G. Ivarsson, Per Unneberg, Sara Light
Publikováno v:
International Journal of Cardiology. 228:742-748
Germline genetic variants are an important cause of dilated cardiomyopathy (DCM). However, recent sequencing studies have revealed rare variants in DCM-associated genes also in individuals without known heart disease. In this study, we investigate va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc969cd8e9f397fce1fbbee31532a9e
https://doi.org/10.1016/j.ijcard.2016.11.066
https://doi.org/10.1016/j.ijcard.2016.11.066
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 3, p e1005375 (2017)
PLoS Computational Biology, Vol 13, Iss 3, p e1005375 (2017)
De novo creation of protein coding genes involves the formation of short ORFs from noncoding regions; some of these ORFs might then become fixed in the population. These orphan proteins need to, at the bare minimum, not cause serious harm to the orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c98b5187cc51dfe8bdefee13789532
http://europepmc.org/articles/PMC5389847
http://europepmc.org/articles/PMC5389847
Publikováno v:
Current Opinion in Structural Biology. 26:73-83
The frequency of de novo creation of proteins has been debated. Early it was assumed that de novo creation should be extremely rare and that the vast majority of all protein coding genes were created in early history of life. However, the early genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5bcfb68a9f5b5dd3bee4f2247f289d
https://doi.org/10.1016/j.sbi.2014.05.006
https://doi.org/10.1016/j.sbi.2014.05.006
Autor:
Morten H. H. Nørholm, Sara Light, Stephen Toddo, Gunnar von Heijne, Minttu T. Virkki, Daniel O. Daley
Publikováno v:
FEBS Letters. 587:2352-2358
Membrane proteins are extremely challenging to produce in sufficient quantities for biochemical and structural analysis and there is a growing demand for solutions to this problem. In this study we attempted to improve expression of two difficult-to-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a65aa4c7ccc04c6d0321855ca90d26
https://doi.org/10.1016/j.febslet.2013.05.063
https://doi.org/10.1016/j.febslet.2013.05.063
De novo creation of protein coding genes involves formation of short ORFs from noncoding regions; some of these ORFs might then become fixed in the population. De novo created proteins need to, at the bare minimum, not cause serious harm to the organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a109879c29b30512542392e7a7d08212
https://doi.org/10.1101/070003
https://doi.org/10.1101/070003
Autor:
Sara Light, Per Warholm
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154059 (2016)
PLoS ONE
PLoS ONE
A large portion of the coding capacity of Mycobacterium tuberculosis is devoted to the production of proteins containing several copies of the pentapeptide-2 repeat, namely the PE/PPE_MPTR proteins. Protein domain repeats have a variety of binding pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eea03b26786e5d1ab7b5ee29c101d62
http://europepmc.org/articles/PMC4858275?pdf=render
http://europepmc.org/articles/PMC4858275?pdf=render
Publikováno v:
Journal of Structural Biology; Vol 179
Particularly in higher eukaryotes, some protein domains are found in tandem repeats, performing broad functions often related to cellular organization. For instance, the eukaryotic protein filamin interacts with many proteins and is crucial for the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1857463b465b60c2b382ee176f3b21a
Publikováno v:
Journal of Molecular Biology. 402:38-51
Protein domain repeats are common in proteins that are central to the organization of a cell, in particular in eukaryotes. They are known to evolve through internal tandem duplications. However, the understanding of the underlying mechanisms is incom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79041b39514a29482bbbe91eead47738
https://doi.org/10.1016/j.jmb.2010.07.011
https://doi.org/10.1016/j.jmb.2010.07.011