Výsledky vyhledávání

The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes

Autor: Simone Baltrusch, Sara Langer, Rica Waterstradt, René Santer, Georg Hillebrand

Publikováno v: Diabetologia

Aims/hypothesis The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism. Monogenic GK disorders emphasise the role of GK in determining the blood glucose set point. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ddf7ca167b636820aaa15830caa784
https://pubmed.ncbi.nlm.nih.gov/34532767

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6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms

Autor: Simone Baltrusch, Sara Langer, Anke Hofmeister-Brix, Rica Waterstradt

Publikováno v: Biochemical pharmacology. 168

Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells and liver. Pharmaceutical efforts to control the enzyme are hampered by an incomplete underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbf16847b12d4202852c5d786539f9e
https://pubmed.ncbi.nlm.nih.gov/31254492

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Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner

Autor: Sara Langer, Simone Baltrusch, Katrin Kollmann, Sigurd Lenzen, Julia Schultz, Anke Hofmeister-Brix

Publikováno v: Journal of Biological Chemistry. 288:35824-35839

Glucokinase acts as a glucose sensor in pancreatic beta cells. Its posttranslational regulation is important but not yet fully understood. Therefore, a pancreatic islet yeast two-hybrid library was produced and searched for glucokinase-binding protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebf9c2ef972925a8cef4905540a1290
https://doi.org/10.1074/jbc.m113.526632

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Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260

Autor: Anke Brix, Sigurd Lenzen, Sara Langer, H Schmitt, Simone Baltrusch

Publikováno v: Biochemical Pharmacology. 83:1300-1306

The glucose phosphorylating enzyme glucokinase plays a crucial role in stimulus-secretion coupling in pancreatic beta cells and in glucose metabolism in liver. Glucose mediates a shift of the enzyme's conformational equilibrium towards the closed con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd88d17a6561c9055783b93d59b9e6f
https://doi.org/10.1016/j.bcp.2012.01.020

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Endogenous Activation of Glucokinase by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Is Glucose Dependent

Autor: Sara Langer, Sigurd Lenzen, Martin Tobias Kaminski, Simone Baltrusch

Publikováno v: Molecular Endocrinology. 24:1988-1997

Glucokinase (GK) plays a crucial role as glucose sensor in glucose-induced insulin secretion in pancreatic β-cells. The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) acts as an endogenous GK activator. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bd47a25ec1fc39674dabc21e3e3ad3
https://doi.org/10.1210/me.2010-0115

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Molecular Coordination of Hepatic Glucose Metabolism by the 6-Phosphofructo-2-Kinase/Fructose-2,6- Bisphosphatase:Glucokinase Complex

Autor: David A. Okar, Simone Baltrusch, Sara Langer, Chaodong Wu, W. Ed Smith

Publikováno v: Molecular Endocrinology. 21:1478-1487

Glucokinase (GK) and 6-phosphofructo-2-kinase (PFK-2)/fructose-2,6-bisphosphatase (FBP-2) are each powerful regulators of hepatic carbohydrate metabolism that have been reported to influence each other's expression, activities, and cellular location.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40d06d0891b44b3daf65d67a259cfe4
https://doi.org/10.1210/me.2006-0356

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Characterization of two MODY2 mutations with different susceptibility to activation

Autor: Simone Baltrusch, Rica Waterstradt, Sara Langer, Christian Platz

Publikováno v: Biochemical and biophysical research communications. 464(4)

Glucokinase plays a key role in glucose sensing in pancreatic beta cells and in liver metabolism. Heterozygous inactivating glucokinase mutations cause the autosomal dominantly inherited MODY2 subtype of maturity-onset diabetes of the young. The goal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce62bd7563593f3fc1b794c64caa270
https://pubmed.ncbi.nlm.nih.gov/26208450

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Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells

Autor: Sara Langer, Sigurd Lenzen, Markus Tiedge, Simone Baltrusch, Laura Massa

Publikováno v: Endocrinology. 147(12)

The glucose sensor enzyme glucokinase plays a pivotal role in the regulation of glucose-induced insulin secretion in pancreatic β-cells. Activation of glucokinase represents a promising concept for the treatment of type 2 diabetes. Therefore, we ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334719c532c0208556417b88f7ebb2cf
https://pubmed.ncbi.nlm.nih.gov/16980436

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