Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sara L. Lopez"'
Autor:
Srijan Ranjitkar, Folkert Reck, Xiaobo Ke, Qingming Zhu, Glenn McEnroe, Sara L. Lopez, Charles R. Dean
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Penicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of β-lactam antibiotics. We identified mutations in the mrdA gene encoding the PBP2 protein in
Externí odkaz:
https://doaj.org/article/3c130500a04c493ebeeaca6cf0d68b31
Autor:
Rumi Asano, Hardwin O’Dowd, Mikhail F. Gordeev, Johanne Blais, Joaquim Trias, Charlotte Wu, Wen Wang, Craig Park, Jason G. Lewis, Sara L. Lopez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2645-2648
The synthesis and evaluation of novel azetidine lincosamides 1 are described. Eleven new (3-trans-alkyl)azetidine-2-carboxylic acids were synthesized via alkylation of N-TBS-4-oxo-azetidine-2-carboxylic acid and subsequent elaboration then coupled to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fa7ff2b2fc571e2b9d6a1c98909e03
https://doi.org/10.1016/j.bmcl.2008.03.032
https://doi.org/10.1016/j.bmcl.2008.03.032
Autor:
Priyadarshini Jaishankar, Dinesh V. Patel, Adam R. Renslo, Mikhail F. Gordeev, C. Hackbarth, Sara L. Lopez, Revathy Venkatachalam
Publikováno v:
Journal of Medicinal Chemistry. 48:5009-5024
The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has becom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6562a90edc2b02e4e2911dc69b118ef2
https://doi.org/10.1021/jm058204j
https://doi.org/10.1021/jm058204j
Autor:
Charlotte Wu, Peter S. Margolis, Johanne Blais, Hardwin O’Dowd, Wen Wang, Sara L. Lopez, Bum Tae Kim
Publikováno v:
Tetrahedron Letters. 48:2003-2005
A method for the selective tetra-Boc-protection of polymyxin B nonapeptide (PMBN) has been developed. Boc-ON selectively protects the amino side chains of the four diaminobutyric acid (Dab) residues in the presence of the N-terminal free amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b33a827ff1702db3afed1dff1808362
https://doi.org/10.1016/j.tetlet.2007.01.071
https://doi.org/10.1016/j.tetlet.2007.01.071