Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sara L. Holland"'
Publikováno v:
Environmental Microbiology
Populations of genetically uniform microorganisms exhibit phenotypic heterogeneity, where individual cells have varying phenotypes. Such phenotypes include fitness-determining traits. Phenotypic heterogeneity has been linked to increased population-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fbf158e1c1f6877f5475f520aec5d
https://doi.org/10.1111/1462-2920.12243
https://doi.org/10.1111/1462-2920.12243
Publikováno v:
Eukaryotic Cell. 11:141-150
We investigated the relevance of gene expression heterogeneity to virulence properties of a major fungal pathogen, Candida glabrata . The organism's key virulence-associated factors include glycosylphosphatidylinositol-anchored adhesins, encoded subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c555a1919d7ba65cfeb7636f7f164356
https://doi.org/10.1128/ec.05232-11
https://doi.org/10.1128/ec.05232-11
Autor:
Sara L. Holland, Simon V. Avery
Publikováno v:
Toxicological Sciences. 111:437-446
Chromate toxicity is well documented, but the underlying toxic mechanism(s) has yet to be fully elucidated. Following a Cr toxicity screen against6000 heterozygous yeast mutants, here we show that Cr resistance requires normal function of the cortica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abaa48d3f6cff1c2f2eac3916f22b7d
https://doi.org/10.1093/toxsci/kfp170
https://doi.org/10.1093/toxsci/kfp170
Publikováno v:
Scientific Reports
There is an unmet need for new antifungal or fungicide treatments, as resistance to existing treatments grows. Combination treatments help to combat resistance. Here we develop a novel, effective target for combination antifungal therapy. Different a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b689d09c0dc3f19ae87ae6912d241636
https://pubmed.ncbi.nlm.nih.gov/26573415
https://pubmed.ncbi.nlm.nih.gov/26573415
Publikováno v:
Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2017, 24 (10), pp.1228-1237.e3. ⟨10.1016/j.chembiol.2017.08.005⟩
Cell Chemical Biology, Cell Press, 2017, 24 (10), pp.1228-1237.e3. ⟨10.1016/j.chembiol.2017.08.005⟩
Summary The essential micronutrient copper is tightly regulated in organisms, as environmental exposure or homeostasis defects can cause toxicity and neurodegenerative disease. The principal target(s) of copper toxicity have not been pinpointed, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41765eeb8bd0422fa2819c3cb4bb6202
https://doi.org/10.1016/j.chembiol.2017.08.005
https://doi.org/10.1016/j.chembiol.2017.08.005
Publikováno v:
Molecular Biology of the Cell
Reactive oxygen species (ROS) are linked to various degenerative conditions, but it is unclear which molecular target(s) may be the cell's primary “Achilles’ heel,” accounting for inhibition by ROS. Our results indicate that the FeS protein Rli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5145c4d6832fd540f138f203c47a55
https://nottingham-repository.worktribe.com/file/711389/1/Avery_Essentioal_iron.pdf
https://nottingham-repository.worktribe.com/file/711389/1/Avery_Essentioal_iron.pdf
Autor:
Simon V. Avery, Sara L. Holland
Publikováno v:
Metallomics : integrated biometal science. 3(11)
The molecular mode(s)-of-action of the toxic metal chromium has yet to be fully resolved. This Mini review focuses on interactions between chromate and sulfur in biological systems. Cr binds sulfur ligands, with cysteine and glutathione having the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce33ee581654d044ea9b727576f6136
https://pubmed.ncbi.nlm.nih.gov/21804974
https://pubmed.ncbi.nlm.nih.gov/21804974
Autor:
Christopher J. Bond, Paul S. Dyer, Simon V. Avery, Sara L. Holland, Steve James, Ian N. Roberts
Publikováno v:
Fungal biology. 115(9)
A new yeast species was isolated from the sediment under metal-contaminated effluent from a disused metal mine in mid-Wales, UK. BLAST searching with DNA sequence amplified from the ribosomal 26S D1/D2 and ITS regions did not reveal a close match wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea8e392849e54b6420da032435ced49
https://pubmed.ncbi.nlm.nih.gov/21872188
https://pubmed.ncbi.nlm.nih.gov/21872188
Toxicity of the environmental carcinogen chromate is known to involve sulfur starvation and also error-prone mRNA translation. Here we reconcile those facts using the yeast model. We demonstrate that: (i) cysteine and methionine starvation mimic Cr-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a96596c5c9b48b2e9cced4e49a71e43
https://europepmc.org/articles/PMC2932861/
https://europepmc.org/articles/PMC2932861/
There is an unmet need for new antifungal or fungicide treatments, as resistance to existing treatments grows. Combination treatments help to combat resistance. Here we develop a novel, effective target for combination antifungal therapy. Different a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ca3c6755e987f9af75ab160b9b2c110c