Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sara L. Deschaine"'
Autor:
András H. Lékó, Adriana Gregory-Flores, Renata C. N. Marchette, Juan L. Gomez, Janaina C. M. Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L. Deschaine, Kimberly E. Whiting, Shelley N. Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D. Janda, Barry Zorman, Pavel Sumazin, George F. Koob, Michael Michaelides, Pietro P. Sanna, Leandro F. Vendruscolo, Lorenzo Leggio
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in
Externí odkaz:
https://doaj.org/article/69dd93baf3cc42269d69f72c7d7939c7
Autor:
Brittney D. Browning, Melanie L. Schwandt, Mehdi Farokhnia, Sara L. Deschaine, Colin A. Hodgkinson, Lorenzo Leggio
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Comorbidity between alcohol use disorder (AUD) and other addictive and psychiatric disorders is highly prevalent and disabling; however, the underlying biological correlates are not fully understood. Leptin is a peptide hormone known for its role in
Externí odkaz:
https://doaj.org/article/43ef49fef9344fe3b7d101d68ad3e407
Autor:
Kusum K. Kharbanda, Mehdi Farokhnia, Sara L. Deschaine, Raghav Bhargava, Marcela Rodriguez‐Flores, Carol A. Casey, Anthony P. Goldstone, Elisabet Jerlhag, Lorenzo Leggio, Karuna Rasineni
Publikováno v:
Alcoholism: Clinical and Experimental Research. 46:2149-2159
Unhealthy alcohol consumption is a global health problem. Adverse individual, public health, and socioeconomic consequences are attributable to harmful alcohol use. Epidemiological studies have shown that alcohol use disorder (AUD) and alcohol-associ
Autor:
Daria Piacentino, Olli Kärkkäinen, Lorenzo Leggio, Anton Klåvus, Shelley N. Jackson, Sara L. Deschaine, Kelly M. Abshire, Marko Lehtonen, Seppo Auriola, Mehdi Farokhnia
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Ghrelin may influence several alcohol-related behaviors in animals and humans by modulating central and/or peripheral biological pathways. The aim of this exploratory analysis was to investigate associations between ghrelin administration
Autor:
Zhi-Bing You, Enoch Cobbina, Aaron Hammer, Sara L. Deschaine, Kelly M. Abshire, Mehdi Farokhnia, Mary R. Lee, Fatemeh Akhlaghi, Anitha Saravanakumar, Lorenzo Leggio, Carolina L. Haass-Koffler
Publikováno v:
Int J Neuropsychopharmacol
Background Accumulating evidence has established a role for the orexigenic hormone ghrelin in alcohol-seeking behaviors. Accordingly, the ghrelin system may represent a potential pharmacotherapeutic target for alcohol use disorder. Ghrelin modulates
Autor:
Mary R. Lee, Dorit Ron, Jillian T. Battista, Lorenzo Leggio, Jeanelle Portelli, Mehdi Farokhnia, Xiaobai Li, Sara L. Deschaine
Publikováno v:
Alcohol
Brain-derived neurotrophic factor (BDNF) plays a role in different neurophysiological processes, including those involved in alcohol- and anxiety-related behaviors. Preclinical and clinical studies indicate that chronic excessive alcohol use leads to
Autor:
Sara L. Deschaine, Morten A. Hedegaard, Claire L. Pince, Mehdi Farokhnia, Jacob E Moose, Ingrid A Stock, Sravani Adusumalli, Fatemeh Akhlaghi, James L. Hougland, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro Vendruscolo, Birgitte Holst, Lorenzo Leggio
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Autor:
Allison M. Daurio, Vijay A. Ramchandani, Sara L. Deschaine, Ryan Bogdan, Mary R. Lee, Jia Yan, Melanie L. Schwandt, Ahmad R. Hariri, Erica N. Grodin, Lorenzo Leggio, Reza Momenan, Jung Hoon Shin, Bethany L. Stangl, Veronica A. Alvarez, Nadia S. Corral-Frías
Publikováno v:
The American Journal of Drug and Alcohol Abuse. 46:167-179
Background: Cluster of differentiation 38 (CD38) is a transmembrane protein expressed in dopaminergic reward pathways in the brain, including the nucleus accumbens (NAc). The GG genotype of a commo...
Autor:
Deon M. Harvey, Fatemeh Akhlaghi, Adriana Gregory-Flores, Hui Sun, Mary R. Lee, Bharath K. Mani, Jacob E. Moose, Leandro F. Vendruscolo, Mehdi Farokhnia, Lorenzo Leggio, Renata C. N. Marchette, James L. Hougland, Eliot L. Gardner, Zhi-Bing You, Marisa Roberto, Sara L. Deschaine, Jeffrey M. Zigman, Lia J. Zallar, Brendan J. Tunstall, George F. Koob
Publikováno v:
Addict Biol
Ghrelin is a gastric-derived peptide hormone with demonstrated impact on alcohol intake and craving, but the reverse side of this bidirectional link, that is, the effects of alcohol on the ghrelin system, remains to be fully established. To further c
Autor:
Sara L. Deschaine, Lisa A. Farinelli, Mary R. Lee, Mehdi Farokhnia, Armin Sadighi, Lorenzo Leggio, Fatemeh Akhlaghi
Publikováno v:
Molecular psychiatry
Previous studies suggest that GABA-B receptor agonism may represent an effective pharmacological approach to treat addictive disorders. Baclofen is a selective GABA-B receptor agonist which has been investigated as a potential treatment for alcohol u