An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model.

Autor: Luís Korrodi-Gregório, Ana Margarida Lopes, Sara L C Esteves, Sandra Afonso, Ana Lemos de Matos, Andrey A Lissovsky, Odete A B da Cruz e Silva, Edgar F da Cruz e Silva, Pedro José Esteves, Margarida Fardilha

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77236 (2013)

T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) contains the canonical phosphoprotein phosphatase 1 (PPP1) binding motif, composed by the amino acid sequence RVSF. We identified and validated the binding of TCTEX1D4 to PPP1 and de

Externí odkaz: https://doaj.org/article/f7f8a10aa5ff410380cf636b330326ba

Can we predict diatoms herbicide sensitivities with phylogeny? Influence of intraspecific and interspecific variability

Autor: Etelvina Lourenço Figueira, Agnès Bouchez, Sara L. C. Esteves, Frédéric Rimet, Salomé F.P. Almeida, François Keck

Publikováno v: Ecotoxicology
Ecotoxicology, Springer Verlag, 2017, ⟨10.1007/s10646-017-1834-z⟩
Ecotoxicology, Springer Verlag, 2017, 26 (8), ⟨10.1007/s10646-017-1834-z⟩

Epub 2017 Jul 06; Diatoms are used as indicators of freshwater ecosystems integrity. Developing diatom-based tools to assess impact of herbicide pollution is expected by water managers. But, defining sensitivities of all species to multiple herbicide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7183b5eb6581ec0b5039639157d640d
https://hal.archives-ouvertes.fr/hal-01604474

Synphilin-1A is a Phosphoprotein Phosphatase 1-Interacting Protein and Affects PPP1 Sorting to Subcellular Compartments

Autor: Margarida Fardilha, Georg H. Lüers, Luís Korrodi-Gregório, Emanuel Ferreira-Fernandes, Sara L. C. Esteves, Vera Afreixo, Odete A. B. da Cruz e Silva

Publikováno v: Journal of Molecular Neuroscience. 55:385-395

Lewy bodies (LBs) are synphilin-1 (Sph1)-containing aggregates and histological hallmarks of Parkinson's disease. Therefore, understanding processes which modulate the aggregation of Sph1, or its isoform Sph1A, will contribute to our understanding of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3727f58a4d14cb401d5a760deb0ce3
https://doi.org/10.1007/s12031-014-0343-2

The Physiological Relevance of Protein Phosphatase 1 and its Interacting Proteins to Health and Disease

Autor: Margarida Fardilha, O. A. B. da Cruz e Silva, Luís Korrodi-Gregório, Sara L. C. Esteves, E. F. da Cruz e Silva

Publikováno v: Current Medicinal Chemistry. 17:3996-4017

Protein phosphorylation is a major regulatory mechanism of signal transduction cascades in eukaryotic cells, catalysed by kinases and reversed by protein phosphatases (PPs). Sequencing of entire genomes has revealed that ~3% of all eukaryotic genes e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ff2ad2d605ecefe7358de891360032
https://doi.org/10.2174/092986710793205363

Phosphoprotein phosphatase 1 isoforms alpha and gamma respond differently to prodigiosin treatment and present alternative kinase targets in melanoma cells

Autor: Luís Korrodi-Gregório, Sandra Rebelo, Odete A. B.da Cruz Silva, Margarida Fardilha, Juliana Felgueiras, Jo~ao Figueiredo, Ricardo Pérez-Tomás, Edgar F. da Cruz e Silva, Margarita Espona-Fiedler, Sara L. C. Esteves

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Dipòsit Digital de la UB
Universidad de Barcelona

Reversible protein phosphorylation is a central regulatory mechanism of cell function. Deregulation of the balanced actions of protein kinases and phosphatases has been frequently associated with several pathological conditions, including cancer. Man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532d33bc3726d40185e9107ec08e9f8e
http://hdl.handle.net/2445/108794